STRINGSTRING
TMEM175 TMEM175 LACC1 LACC1 AVPR1B AVPR1B ATP6V1F ATP6V1F TMEM9 TMEM9 LRRK2 LRRK2 RAB7A RAB7A VPS33A VPS33A ATP1A4 ATP1A4 CHP1 CHP1 SLC26A3 SLC26A3 SLC9B1 SLC9B1 SLC4A5 SLC4A5 ATP6V0A4 ATP6V0A4 NOX1 NOX1 CA2 CA2 RNASEK RNASEK ATP6V0A2 ATP6V0A2 ATP5B ATP5B RHCG RHCG ATP6V1B2 ATP6V1B2 SLC9A9 SLC9A9 TMEM106B TMEM106B EDN1 EDN1 PDK4 PDK4 SLC9A4 SLC9A4 SLC9A2 SLC9A2 ATP6V1B1 ATP6V1B1 SLC26A4 SLC26A4 RAB38 RAB38 ATP6V1H ATP6V1H SLC9A5 SLC9A5 SNAPIN SNAPIN TM9SF4 TM9SF4 SLC11A1 SLC11A1 TMEM165 TMEM165 ENSTSYP00000015122 ENSTSYP00000015122 SLC9A7 SLC9A7 AVP AVP RAB20 RAB20 LOC103270920 LOC103270920 EDNRB EDNRB GRN GRN SLC4A3 SLC4A3 SLC26A6 SLC26A6 ATP6AP1 ATP6AP1 ATP4B ATP4B CLN6 CLN6 UBE3A UBE3A SLC4A4 SLC4A4 ATP6V0B ATP6V0B DMXL2 DMXL2 CCDC115 CCDC115 ATP6AP2 ATP6AP2 HVCN1 HVCN1 TMEM199 TMEM199 ENSTSYP00000022998 ENSTSYP00000022998 ENSTSYP00000023511 ENSTSYP00000023511 CLIC4 CLIC4 LOC103251114 LOC103251114 SLC9A1 SLC9A1 ATP12A ATP12A SLC4A8 SLC4A8 RAB39A RAB39A SLC4A1 SLC4A1 PPT1 PPT1 LOC103268441 LOC103268441 ATP6V0C ATP6V0C LOC103258166 LOC103258166 SLC12A5 SLC12A5 MAPK3 MAPK3 PDK2 PDK2 DMXL1 DMXL1 SLC4A9 SLC4A9 SLC9A8 SLC9A8 CLN3 CLN3 SLC4A7 SLC4A7 MAFG MAFG SLC9A6 SLC9A6 AVPR1A AVPR1A MAPK1 MAPK1 SLC9A3 SLC9A3 CFTR CFTR CA7 CA7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM175Endosomal/lysomomal potassium channel TMEM175 isoform X3. (504 aa)
LACC1Laccase domain-containing protein 1. (430 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (425 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (143 aa)
TMEM9LOW QUALITY PROTEIN: transmembrane protein 9. (183 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2527 aa)
RAB7ARas-related protein Rab-7a isoform X1. (214 aa)
VPS33AVacuolar protein sorting-associated protein 33A isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
CHP1Calcineurin B homologous protein 1. (171 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (760 aa)
SLC9B1Sodium/hydrogen exchanger 9B1. (515 aa)
SLC4A5Anion exchange protein. (1134 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
NOX1NADPH oxidase 1 isoform X1. (564 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
RNASEKRibonuclease kappa isoform X1. (131 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (817 aa)
ATP5BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
RHCGAmmonium transporter Rh type C; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (477 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (526 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (641 aa)
TMEM106BTransmembrane protein 106B. (274 aa)
EDN1Endothelin-1. (202 aa)
PDK4Protein-serine/threonine kinase. (390 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (797 aa)
SLC9A2Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (807 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (506 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (730 aa)
RAB38Ras-related protein Rab-38. (211 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (453 aa)
SLC9A5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (886 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (652 aa)
SLC11A1Natural resistance-associated macrophage protein 1 isoform X1. (522 aa)
TMEM165GDT1 family protein. (293 aa)
ENSTSYP00000015122annotation not available (382 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (724 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (107 aa)
RAB20Ras-related protein Rab-20. (180 aa)
LOC103270920V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (137 aa)
EDNRBEndothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (283 aa)
GRNGranulins. (590 aa)
SLC4A3Anion exchange protein. (1232 aa)
SLC26A6Solute carrier family 26 member 6. (728 aa)
ATP6AP1V-type proton ATPase subunit S1. (470 aa)
ATP4BPotassium-transporting ATPase subunit beta. (218 aa)
CLN6Ceroid-lipofuscinosis neuronal protein 6. (319 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (873 aa)
SLC4A4Anion exchange protein. (1027 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family. (236 aa)
DMXL2dmX-like protein 2 isoform X2. (3037 aa)
CCDC115LOW QUALITY PROTEIN: coiled-coil domain-containing protein 115. (169 aa)
ATP6AP2Renin receptor isoform X1. (301 aa)
HVCN1Voltage-gated hydrogen channel 1. (259 aa)
TMEM199Transmembrane protein 199. (184 aa)
ENSTSYP00000022998annotation not available (405 aa)
ENSTSYP00000023511annotation not available (453 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (229 aa)
LOC103251114ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (505 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (811 aa)
ATP12ASodium/potassium-transporting ATPase subunit alpha. (1028 aa)
SLC4A8Anion exchange protein. (1094 aa)
RAB39ARas-related protein Rab-39A. (217 aa)
SLC4A1Anion exchange protein. (853 aa)
PPT1Palmitoyl-protein thioesterase 1 isoform X1. (306 aa)
LOC103268441Golgi pH regulator isoform X1. (455 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
LOC103258166V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (153 aa)
SLC12A5Solute carrier family 12 member 5. (1136 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
DMXL1dmX-like protein 1. (2074 aa)
SLC4A9Anion exchange protein. (975 aa)
SLC9A8Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (581 aa)
CLN3Battenin. (438 aa)
SLC4A7Anion exchange protein. (1212 aa)
MAFGTranscription factor MafG. (162 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (710 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (418 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (746 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1480 aa)
CA7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.