STRINGSTRING
THBS4 THBS4 BMP5 BMP5 FGF16 FGF16 CD320 CD320 IL12A IL12A PTN PTN MANF MANF BMP10 BMP10 BTC BTC VEGFC VEGFC NENF NENF INHBE INHBE JAG1 JAG1 BMP6 BMP6 BMP3 BMP3 FGF12 FGF12 GMFB GMFB NRG4 NRG4 NODAL NODAL EREG EREG MSTN MSTN NRG3 NRG3 THPO THPO PROK1 PROK1 VEGFD VEGFD EFEMP1 EFEMP1 FBRS FBRS CXCL1 CXCL1 CSF2 CSF2 NTF3 NTF3 MACC1 MACC1 EGF EGF GDF9 GDF9 ANGPTL3 ANGPTL3 IL4 IL4 AREG AREG GKN1 GKN1 IL5 IL5 OSGIN2 OSGIN2 SPEM1 SPEM1 PDGFC PDGFC HBEGF HBEGF GDF6 GDF6 PDGFD PDGFD GDF2 GDF2 FAM71F1 FAM71F1 HGF HGF FAM71F2 FAM71F2 TDGF1 TDGF1 GDNF GDNF INHBC INHBC CDNF CDNF FGF5 FGF5 IL9 IL9 HDGFL3 HDGFL3 AMBN AMBN ENDOU ENDOU FGF6 FGF6 FGF11 FGF11 CCN3 CCN3 FGF3 FGF3 GDF5 GDF5 FGF7 FGF7 INHBA INHBA RABEP2 RABEP2 GRN GRN GDF10 GDF10 IL7 IL7 OGN OGN INHA INHA FGF13 FGF13 FGF1 FGF1 BMP1 BMP1 VEGFA VEGFA IL11 IL11 FGF20 FGF20 OSM OSM FGF20-2 FGF20-2 FGF17 FGF17 GDF11 GDF11 RABEP1 RABEP1 BDNF BDNF FGF10 FGF10 TGFA TGFA FGF9 FGF9 KITLG KITLG CUNH17orf74 CUNH17orf74 FGF21 FGF21 IGF2 IGF2 LIF LIF IL34 IL34 FGF18 FGF18 CSF3 CSF3 TIMP1 TIMP1 OSGIN1 OSGIN1 BMP4 BMP4 NGF NGF CSF1 CSF1 VEGFB VEGFB NRG1 NRG1 CLCF1 CLCF1 LOC103269949 LOC103269949 IL2 IL2 GH1 GH1 IGF1 IGF1 LOC103269764 LOC103269764 PDGFB PDGFB PSPN PSPN TGFB3 TGFB3 ARTN ARTN DKK1 DKK1 EPGN EPGN TGFB1 TGFB1 HDGF HDGF TGFB2 TGFB2 IL6 IL6 CLEC11A CLEC11A GFER GFER PPBP PPBP PGF PGF JAG2 JAG2 TFF1 TFF1 ENSTSYP00000033115 ENSTSYP00000033115 PDGFA PDGFA GMFG GMFG NRG2 NRG2 CCN2 CCN2 CNTF CNTF MIA MIA BMP2 BMP2 BMP7 BMP7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THBS4Thrombospondin-4. (865 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (454 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
CD320CD320 antigen. (262 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
PTNPleiotrophin isoform X1. (168 aa)
MANFMesencephalic astrocyte-derived neurotrophic factor. (182 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
BTCProbetacellulin. (178 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (407 aa)
NENFNeudesin; Belongs to the cytochrome b5 family. (172 aa)
INHBEInhibin beta E chain. (354 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
BMP6Bone morphogenetic protein 6. (513 aa)
BMP3Bone morphogenetic protein 3. (409 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (158 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
NODALNodal homolog. (332 aa)
EREGProepiregulin. (167 aa)
MSTNGrowth/differentiation factor 8. (376 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X2. (344 aa)
THPOThrombopoietin isoform X1. (359 aa)
PROK1Prokineticin-1. (105 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (351 aa)
EFEMP1EGF-containing fibulin-like extracellular matrix protein 1. (492 aa)
FBRSProbable fibrosin-1. (977 aa)
CXCL1C-X-C motif chemokine. (107 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (264 aa)
MACC1LOW QUALITY PROTEIN: metastasis-associated in colon cancer protein 1. (849 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
GDF9Growth/differentiation factor 9 isoform X1. (454 aa)
ANGPTL3Angiopoietin-related protein 3. (460 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (142 aa)
AREGAmphiregulin isoform X1. (270 aa)
GKN1Gastrokine-1. (199 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
OSGIN2Oxidative stress-induced growth inhibitor 2. (550 aa)
SPEM1Spermatid maturation protein 1. (310 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (345 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
GDF6Growth/differentiation factor 6. (457 aa)
PDGFDPlatelet-derived growth factor D. (370 aa)
GDF2Growth/differentiation factor 2. (428 aa)
FAM71F1Protein FAM71F1. (344 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
FAM71F2Protein FAM71F2. (303 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X3. (211 aa)
INHBCInhibin beta C chain. (348 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
IL9Interleukin-9. (144 aa)
HDGFL3Hepatoma-derived growth factor-related protein 3. (203 aa)
AMBNAmeloblastin. (423 aa)
ENDOUpoly(U)-specific endoribonuclease isoform X1. (412 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
CCN3Protein NOV homolog. (255 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
GDF5Growth/differentiation factor 5. (499 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
INHBAInhibin beta A chain. (426 aa)
RABEP2Rab GTPase-binding effector protein 2. (456 aa)
GRNGranulins. (590 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (476 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
OGNMimecan isoform X2. (298 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (367 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
BMP1Metalloendopeptidase. (945 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
IL11Interleukin-11. (120 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
OSMoncostatin-M. (251 aa)
FGF20-2Fibroblast growth factor 20. (75 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
GDF11Growth/differentiation factor 11. (258 aa)
RABEP1Rab GTPase-binding effector protein 1 isoform X1. (867 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (328 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TGFATransforming growth factor alpha. (164 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
CUNH17orf74Uncharacterized protein C17orf74 homolog. (486 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
IGF2Insulin like growth factor 2. (147 aa)
LIFLeukemia inhibitory factor. (202 aa)
IL34Interleukin-34 isoform X1. (240 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
CSF3Granulocyte colony-stimulating factor isoform X2. (204 aa)
TIMP1Metalloproteinase inhibitor 1 isoform X2. (207 aa)
OSGIN1Oxidative stress-induced growth inhibitor 1. (549 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (409 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (268 aa)
CSF1Macrophage colony-stimulating factor 1. (244 aa)
VEGFBVascular endothelial growth factor B. (181 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (260 aa)
LOC103269949Left-right determination factor. (366 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
GH1Somatotropin. (214 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
LOC103269764Stromal cell-derived factor 1-like; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
PSPNPersephin. (107 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ARTNArtemin. (154 aa)
DKK1Dickkopf-related protein 1. (268 aa)
EPGNEpigen isoform X1. (153 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
HDGFHepatoma-derived growth factor isoform X2. (250 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IL6Interleukin-6. (209 aa)
CLEC11AC-type lectin domain family 11 member A. (268 aa)
GFERSulfhydryl oxidase. (131 aa)
PPBPC-X-C motif chemokine. (128 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1101 aa)
TFF1Trefoil factor 1. (80 aa)
ENSTSYP00000033115annotation not available (96 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
GMFGGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (243 aa)
CCN2Connective tissue growth factor. (297 aa)
CNTFCiliary neurotrophic factor. (200 aa)
MIAMelanoma-derived growth regulatory protein. (131 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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