STRINGSTRING
PINK1 PINK1 CPTP CPTP UBQLN4 UBQLN4 ENSTSYP00000022061 ENSTSYP00000022061 PTPN22 PTPN22 TSC2 TSC2 RNF41 RNF41 RRAGA RRAGA TBC1D14 TBC1D14 TP53 TP53 WDR6 WDR6 MT3 MT3 SMCR8 SMCR8 LEPR LEPR HMOX1 HMOX1 CTSA CTSA ENSTSYP00000027241 ENSTSYP00000027241 LOC103274931 LOC103274931 TAB3 TAB3 TMEM39B TMEM39B MLST8 MLST8 AKT1 AKT1 ENSTSYP00000031096 ENSTSYP00000031096 NRBP2 NRBP2 TSPO TSPO EIF4G1 EIF4G1 ENSTSYP00000031894 ENSTSYP00000031894 LOC103249566 LOC103249566 SMG1 SMG1 RASIP1 RASIP1 DAP DAP LOC103277171 LOC103277171 CHMP4B CHMP4B SEC22B SEC22B BCL2L1 BCL2L1 QSOX1 QSOX1 POLDIP2 POLDIP2 RPTOR RPTOR DAPL1 DAPL1 CLEC16A CLEC16A HTR2B HTR2B HGF HGF MTOR MTOR STAT3 STAT3 ADRA1A ADRA1A IL10RA IL10RA USP36 USP36 GATA4 GATA4 NUPR1 NUPR1 MTMR8 MTMR8 TAB2 TAB2 TSC1 TSC1 KLHL22 KLHL22 TIGAR TIGAR TMEM39A TMEM39A IL10 IL10 NPC1 NPC1 ZKSCAN3 ZKSCAN3 KDM4A KDM4A FEZ2 FEZ2 PIK3CA PIK3CA FEZ1 FEZ1 RUBCN RUBCN TLK2 TLK2 LRRK2 LRRK2 FOXK2 FOXK2 ATG7 ATG7 MTMR9 MTMR9 PHF23 PHF23 LZTS1 LZTS1 TREM2 TREM2 GEMIN6 GEMIN6 FOXK1 FOXK1 SLC7A5 SLC7A5 SIRT2 SIRT2 HERC1 HERC1 RNF5 RNF5 SCFD1 SCFD1 EHMT2 EHMT2 BMF BMF ENSTSYP00000019529 ENSTSYP00000019529
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (510 aa)
CPTPCeramide-1-phosphate transfer protein. (214 aa)
UBQLN4Ubiquilin-4. (601 aa)
ENSTSYP00000022061annotation not available (180 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (811 aa)
TSC2LOW QUALITY PROTEIN: tuberin. (1728 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform X1. (317 aa)
RRAGARas-related GTP-binding protein A. (298 aa)
TBC1D14TBC1 domain family member 14 isoform X1. (693 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
WDR6WD repeat-containing protein 6. (1152 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (111 aa)
SMCR8Guanine nucleotide exchange protein SMCR8. (938 aa)
LEPRLeptin receptor. (961 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (475 aa)
ENSTSYP00000027241annotation not available (106 aa)
LOC103274931Ubiquitin carboxyl-terminal hydrolase 30; Belongs to the peptidase C19 family. (244 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (711 aa)
TMEM39BTransmembrane protein 39B isoform X1. (492 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X2. (326 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
ENSTSYP00000031096annotation not available (176 aa)
NRBP2Nuclear receptor-binding protein 2 isoform X2. (499 aa)
TSPOTranslocator protein. (169 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1 isoform X5. (1608 aa)
ENSTSYP00000031894annotation not available (263 aa)
LOC103249566U1 small nuclear ribonucleoprotein 70 kDa isoform X3. (124 aa)
SMG1Serine/threonine-protein kinase SMG1; Belongs to the PI3/PI4-kinase family. (3611 aa)
RASIP1Ras-interacting protein 1. (318 aa)
DAPDeath-associated protein 1 isoform X2. (102 aa)
LOC103277171LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like. (248 aa)
CHMP4BCharged multivesicular body protein 4b. (200 aa)
SEC22BVesicle-trafficking protein SEC22b; Belongs to the synaptobrevin family. (215 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
QSOX1Sulfhydryl oxidase. (646 aa)
POLDIP2Polymerase delta-interacting protein 2-like. (368 aa)
RPTORRegulatory-associated protein of mTOR. (1012 aa)
DAPL1Death-associated protein-like 1. (107 aa)
CLEC16AProtein CLEC16A. (1049 aa)
HTR2B5-hydroxytryptamine receptor 2B isoform X1. (480 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
STAT3Signal transducer and activator of transcription 3. (444 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
IL10RAInterleukin-10 receptor subunit alpha. (581 aa)
USP36Ubiquitin carboxyl-terminal hydrolase 36; Belongs to the peptidase C19 family. (1122 aa)
GATA4Transcription factor GATA-4. (234 aa)
NUPR1Nuclear protein 1. (99 aa)
MTMR8Myotubularin-related protein 8. (450 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
TSC1Hamartin isoform X2. (1164 aa)
KLHL22Kelch-like protein 22. (636 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (270 aa)
TMEM39ATransmembrane protein 39A. (488 aa)
IL10Interleukin-10. (178 aa)
NPC1Niemann-Pick C1 protein. (1278 aa)
ZKSCAN3Zinc finger protein with KRAB and SCAN domains 3-like. (547 aa)
KDM4ALysine-specific demethylase 4A. (1064 aa)
FEZ2Fasciculation and elongation protein zeta-2 isoform X3. (182 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FEZ1Fasciculation and elongation protein zeta-1 isoform X1. (392 aa)
RUBCNRun domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X3. (970 aa)
TLK2Serine/threonine-protein kinase tousled-like 2. (739 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2527 aa)
FOXK2Forkhead box protein K2 isoform X1. (661 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (651 aa)
MTMR9Myotubularin-related protein 9. (444 aa)
PHF23PHD finger protein 23 isoform X1. (403 aa)
LZTS1Leucine zipper putative tumor suppressor 1. (597 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
GEMIN6Gem-associated protein 6. (167 aa)
FOXK1Forkhead box protein K1. (618 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (491 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
HERC1Probable E3 ubiquitin-protein ligase HERC1 isoform X1. (4865 aa)
RNF5E3 ubiquitin-protein ligase RNF5. (177 aa)
SCFD1Sec1 family domain-containing protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (634 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
BMFLOW QUALITY PROTEIN: bcl-2-modifying factor. (184 aa)
ENSTSYP00000019529annotation not available (104 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.