STRINGSTRING
LOC103251114 LOC103251114 MAP3K3 MAP3K3 ZC3H12A ZC3H12A BSG BSG PIK3CG PIK3CG HDAC7 HDAC7 FGFR1 FGFR1 FGF10 FGF10 PPM1F PPM1F CD40 CD40 EMC10 EMC10 TEK TEK SRPX2 SRPX2 HDAC9 HDAC9 VIL1 VIL1 CLASP2 CLASP2 VEGFA VEGFA ROCK2 ROCK2 FGF1 FGF1 LOC103276437 LOC103276437 ARF6 ARF6 LOC103274473 LOC103274473 SMOC2 SMOC2 SCARB1 SCARB1 JCAD JCAD ENSTSYP00000016980 ENSTSYP00000016980 FOXP1 FOXP1 LOC103250564 LOC103250564 GRN GRN RAB25 RAB25 FGF7 FGF7 LOC103260607 LOC103260607 PLCG2 PLCG2 HIF1A HIF1A MAP4K4 MAP4K4 HYAL1 HYAL1 LOC103255477 LOC103255477 ENSTSYP00000014176 ENSTSYP00000014176 PRKD2 PRKD2 BCAS3 BCAS3 SASH1 SASH1 ADAM9 ADAM9 ANXA3 ANXA3 ADGRA2 ADGRA2 TDGF1 TDGF1 CAPN7 CAPN7 MTOR MTOR PTGS2 PTGS2 WNT7A WNT7A BCAR1 BCAR1 RIN2 RIN2 SIRT1 SIRT1 RRAS RRAS HBEGF HBEGF AKT3 AKT3 ANGPT1 ANGPT1 ATP5B ATP5B GPLD1 GPLD1 EGF EGF RHOJ RHOJ ADAM17 ADAM17 ITGA2 ITGA2 ATP5A1 ATP5A1 PLK2 PLK2 LOC103263247 LOC103263247 PDPK1 PDPK1 RREB1 RREB1 PTK2B PTK2B PIK3CB PIK3CB ALOX12 ALOX12 SRC SRC ENSTSYP00000033115 ENSTSYP00000033115 ENSTSYP00000031763 ENSTSYP00000031763 TGFB2 TGFB2 AKT1 AKT1 TGFB1 TGFB1 EPB41L5 EPB41L5 PIK3CD PIK3CD PDGFB PDGFB SPARC SPARC CLASP1 CLASP1 ITGB1BP1 ITGB1BP1 LOC103272981 LOC103272981 MAPRE2 MAPRE2 ANGPT4 ANGPT4 ETS1 ETS1 CALR CALR TACR1 TACR1 HAS2 HAS2 SEMA5A SEMA5A CIB1 CIB1 HMOX1 HMOX1 GATA3 GATA3 BMP4 BMP4 NOS3 NOS3 EPB41L4B EPB41L4B FGF16 FGF16 NFE2L2 NFE2L2 MET MET SP1 SP1 IFNG IFNG LGMN LGMN MMP9 MMP9 NRP1 NRP1 VEGFC VEGFC ABL1 ABL1 ENPP2 ENPP2 TGFBR2 TGFBR2 AAMP AAMP PROX1 PROX1 PRKD1 PRKD1 TSTA3 TSTA3 THBS1 THBS1 HDAC6 HDAC6 LOC103254094 LOC103254094 NUS1 NUS1 AMOT AMOT PRKCA PRKCA PLCG1 PLCG1 ANXA1 ANXA1 KDR KDR PLPP3 PLPP3 CCBE1 CCBE1 AGT AGT MAP2K3 MAP2K3 CTSH CTSH GLIPR2 GLIPR2 FGF18 FGF18 P2RX4 P2RX4 RHOB RHOB IQSEC1 IQSEC1 RTN4 RTN4 ENSTSYP00000024821 ENSTSYP00000024821 NRP2 NRP2 WNT5A WNT5A BMPR2 BMPR2 STAT5A STAT5A LOC103252420 LOC103252420
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103251114ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (505 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (528 aa)
ZC3H12AEndoribonuclease ZC3H12A isoform X1. (593 aa)
BSGLOW QUALITY PROTEIN: basigin. (234 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (983 aa)
FGFR1Fibroblast growth factor receptor. (832 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PPM1FProtein phosphatase 1F. (448 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X2. (277 aa)
EMC10ER membrane protein complex subunit 10. (254 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
SRPX2Sushi repeat-containing protein SRPX2. (465 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1065 aa)
VIL1Villin-1. (828 aa)
CLASP2CLIP-associating protein 2 isoform X2. (1495 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1376 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOC103276437Vascular endothelial growth factor receptor 3-like. (295 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
LOC103274473Breast carcinoma-amplified sequence 3-like. (52 aa)
SMOC2SPARC-related modular calcium-binding protein 2. (313 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (467 aa)
JCADJunctional protein associated with coronary artery disease. (1383 aa)
ENSTSYP00000016980annotation not available (233 aa)
FOXP1Forkhead box protein P1 isoform X1. (694 aa)
LOC103250564Integrin beta; Belongs to the integrin beta chain family. (418 aa)
GRNGranulins. (590 aa)
RAB25Ras-related protein Rab-25. (213 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
LOC103260607Microtubule-associated protein RP/EB family member 2-like isoform X2. (311 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (842 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4 isoform X1. (1342 aa)
HYAL1Hyaluronidase. (435 aa)
LOC103255477Transcription factor Sp1-like. (259 aa)
ENSTSYP00000014176annotation not available (562 aa)
PRKD2Serine/threonine-protein kinase D2. (853 aa)
BCAS3Breast carcinoma-amplified sequence 3. (470 aa)
SASH1SAM and SH3 domain-containing protein 1 isoform X1. (1231 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9. (795 aa)
ANXA3Annexin. (323 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1076 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
CAPN7Calpain-7 isoform X1; Belongs to the peptidase C2 family. (779 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (297 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (871 aa)
RIN2Ras and Rab interactor 2. (874 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (729 aa)
RRASRas-related protein R-Ras. (218 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
ATP5BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (840 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
RHOJRho-related GTP-binding protein RhoJ. (214 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (824 aa)
ITGA2LOW QUALITY PROTEIN: integrin alpha-2; Belongs to the integrin alpha chain family. (1175 aa)
ATP5A1ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (560 aa)
PLK2Serine/threonine-protein kinase PLK2. (685 aa)
LOC103263247Arachidonate 12-lipoxygenase, 12S-type-like. (669 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (554 aa)
RREB1LOW QUALITY PROTEIN: ras-responsive element-binding protein 1. (1448 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
SRCTyrosine-protein kinase. (542 aa)
ENSTSYP00000033115annotation not available (96 aa)
ENSTSYP00000031763annotation not available (161 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
EPB41L5Band 4.1-like protein 5. (734 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
SPARCSPARC isoform X3. (303 aa)
CLASP1CLIP-associating protein 1. (1539 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (200 aa)
LOC103272981Dedicator of cytokinesis protein 5-like; Belongs to the DOCK family. (334 aa)
MAPRE2Microtubule-associated protein RP/EB family member 2 isoform X1. (327 aa)
ANGPT4Angiopoietin-4. (488 aa)
ETS1Protein C-ets-1 isoform X1. (485 aa)
CALRCalreticulin. (416 aa)
TACR1substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
HAS2Hyaluronan synthase 2. (552 aa)
SEMA5Asemaphorin-5A. (335 aa)
CIB1Calcium and integrin-binding protein 1 isoform X3. (191 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (436 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (409 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
EPB41L4BBand 4.1-like protein 4B. (877 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (591 aa)
METHepatocyte growth factor receptor isoform X1. (1415 aa)
SP1Transcription factor Sp1. (668 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
LGMNLegumain. (433 aa)
MMP9Matrix metalloproteinase-9. (710 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (927 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (407 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X2. (915 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (558 aa)
AAMPAngio-associated migratory cell protein isoform X2. (451 aa)
PROX1Prospero homeobox protein 1. (737 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
TSTA3GDP-L-fucose synthase isoform X1. (321 aa)
THBS1Thrombospondin-1. (1178 aa)
HDAC6Histone deacetylase 6. (1213 aa)
LOC103254094Dedicator of cytokinesis protein 1-like; Belongs to the DOCK family. (696 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
AMOTAngiomotin. (1101 aa)
PRKCAProtein kinase C. (614 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
ANXA1Annexin. (346 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
CCBE1Collagen and calcium-binding EGF domain-containing protein 1. (337 aa)
AGTAngiotensinogen; Belongs to the serpin family. (487 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. (149 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
P2RX4P2X purinoceptor 4 isoform X2. (388 aa)
RHOBRho-related GTP-binding protein RhoB isoform X1. (196 aa)
IQSEC1IQ motif and SEC7 domain-containing protein 1 isoform X1. (1082 aa)
RTN4Reticulon. (1102 aa)
ENSTSYP00000024821annotation not available (65 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (928 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
STAT5ASignal transducer and activator of transcription. (669 aa)
LOC103252420Endothelial transcription factor GATA-2. (93 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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