STRINGSTRING
FN1 FN1 LOC103271953 LOC103271953 F2 F2 EGFR EGFR PRR5L PRR5L SERPINE2 SERPINE2 PIP5K1A PIP5K1A AGT AGT KDR KDR PTPN13 PTPN13 IGF1R IGF1R LOC103261480 LOC103261480 FSHR FSHR PLXNB1 PLXNB1 CEP55 CEP55 SEMA4D SEMA4D PTPN6 PTPN6 MYDGF MYDGF CUNH3orf58 CUNH3orf58 TREM2 TREM2 LOC103264991 LOC103264991 RELN RELN UNC5B UNC5B NLRC3 NLRC3 BTN2A2 BTN2A2 HGF HGF HCLS1 HCLS1 SIRT1 SIRT1 AGAP2 AGAP2 NCF1 NCF1 UBE3A UBE3A TEK TEK PPP1R16B PPP1R16B PDGFC PDGFC ANGPT1 ANGPT1 JAK2 JAK2 ROR1 ROR1 WNT16 WNT16 EGF EGF SEMA3E SEMA3E ERBB4 ERBB4 FGFR1 FGFR1 TSC2 TSC2 SLC9A3R1 SLC9A3R1 CRYBA1 CRYBA1 PPARD PPARD PTK2 PTK2 CSF3 CSF3 SERPINA12 SERPINA12 NTRK1 NTRK1 CRNN CRNN NEDD4 NEDD4 NOP53 NOP53 DAB2IP DAB2IP PIK3AP1 PIK3AP1 PDGFRB PDGFRB IGF1 IGF1 PDGFB PDGFB CBL CBL TGFB2 TGFB2 PTEN PTEN PIK3IP1 PIK3IP1 SRC SRC PDGFA PDGFA MAZ MAZ IL18 IL18 LOC103250673 LOC103250673 STAMBP STAMBP RASGRP1 RASGRP1 FBXL2 FBXL2 HCST HCST SELP SELP PIP5K1C PIP5K1C DCN DCN ENSTSYP00000020437 ENSTSYP00000020437 OSM OSM CD28 CD28 MYOC MYOC LOC103258924 LOC103258924 FGR FGR NTRK2 NTRK2 PRR5 PRR5 FLT3 FLT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FN1Fibronectin isoform X2. (2450 aa)
LOC103271953Vascular endothelial growth factor receptor 1-like. (713 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
PRR5LProline-rich protein 5-like. (341 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (408 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2. (581 aa)
AGTAngiotensinogen; Belongs to the serpin family. (487 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PTPN13Tyrosine-protein phosphatase non-receptor type 13 isoform X1. (2492 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
LOC103261480Carcinoembryonic antigen-related cell adhesion molecule 1-like isoform X2. (524 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (620 aa)
PLXNB1plexin-B1. (2134 aa)
CEP55Centrosomal protein of 55 kDa. (395 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (733 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (402 aa)
MYDGFMyeloid-derived growth factor. (115 aa)
CUNH3orf58Deleted in autism protein 1 isoform X1. (221 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
LOC103264991Vascular endothelial growth factor receptor 1 isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (431 aa)
RELNReelin. (3443 aa)
UNC5BNetrin receptor UNC5B. (907 aa)
NLRC3NLR family CARD domain-containing protein 3. (1065 aa)
BTN2A2Butyrophilin subfamily 2 member A2-like. (519 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
HCLS1Hematopoietic lineage cell-specific protein. (469 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (729 aa)
AGAP2LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (784 aa)
NCF1LOW QUALITY PROTEIN: neutrophil cytosol factor 1. (232 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (873 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
PPP1R16BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory inhibitor subunit 16B-like. (476 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
ROR1Inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
SEMA3Esemaphorin-3E isoform X1; Belongs to the semaphorin family. (735 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
FGFR1Fibroblast growth factor receptor. (832 aa)
TSC2LOW QUALITY PROTEIN: tuberin. (1728 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1. (202 aa)
CRYBA1Beta-crystallin A3; Belongs to the beta/gamma-crystallin family. (215 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
CSF3Granulocyte colony-stimulating factor isoform X2. (204 aa)
SERPINA12Serpin A12; Belongs to the serpin family. (410 aa)
NTRK1High affinity nerve growth factor receptor. (721 aa)
CRNNCornulin. (480 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X1. (1321 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (439 aa)
DAB2IPDisabled homolog 2-interacting protein. (1088 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1. (849 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
CBLE3 ubiquitin-protein ligase CBL. (898 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PIK3IP1Phosphoinositide-3-kinase-interacting protein 1 isoform X1. (261 aa)
SRCTyrosine-protein kinase. (542 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
MAZMyc-associated zinc finger protein. (94 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
LOC103250673HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (278 aa)
STAMBPSTAM-binding protein. (424 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (792 aa)
FBXL2F-box/LRR-repeat protein 2. (422 aa)
HCSTHematopoietic cell signal transducer isoform X2. (92 aa)
SELPP-selectin. (830 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (698 aa)
DCNDecorin; May affect the rate of fibrils formation. (361 aa)
ENSTSYP00000020437annotation not available (273 aa)
OSMoncostatin-M. (251 aa)
CD28T-cell-specific surface glycoprotein CD28 isoform X2. (221 aa)
MYOCMyocilin. (492 aa)
LOC103258924Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (142 aa)
FGRTyrosine-protein kinase. (526 aa)
NTRK2BDNF/NT-3 growth factors receptor isoform X1. (553 aa)
PRR5Proline-rich protein 5 isoform X1. (388 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (980 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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