STRINGSTRING
INSR INSR WNT5A WNT5A MT3 MT3 NRG1 NRG1 ITGB1BP1 ITGB1BP1 IGF1 IGF1 PDGFB PDGFB SRC SRC IL18 IL18 NTRK3 NTRK3 SLC1A1 SLC1A1 PDPK1 PDPK1 PINK1 PINK1 NTF3 NTF3 DYNAP DYNAP FGF1 FGF1 MTOR MTOR GAS6 GAS6 PARK7 PARK7 OSBPL8 OSBPL8 ENSTSYP00000015305 ENSTSYP00000015305 CCDC88A CCDC88A PRKCZ PRKCZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSRTyrosine-protein kinase receptor. (1356 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (111 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (200 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
SRCTyrosine-protein kinase. (542 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
NTRK3NT-3 growth factor receptor isoform X1. (529 aa)
SLC1A1Amino acid transporter. (524 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (554 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (510 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (264 aa)
DYNAPLOW QUALITY PROTEIN: dynactin-associated protein. (198 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
GAS6Growth arrest-specific protein 6. (440 aa)
PARK7Protein DJ-1. (189 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
ENSTSYP00000015305annotation not available (177 aa)
CCDC88AGirdin isoform X4. (1874 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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