(37 nodes) Non-canonical Wnt signaling pathway network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MYOC	Myocilin. (492 aa)
	SMURF2	E3 ubiquitin-protein ligase. (662 aa)
	TIAM1	T-lymphoma invasion and metastasis-inducing protein 1. (1592 aa)
	FZD6	Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (703 aa)
	RYK	Tyrosine-protein kinase RYK isoform X2. (529 aa)
	VANGL1	Vang-like protein. (524 aa)
	GPC4	Glypican-4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (502 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2796 aa)
	CTHRC1	Collagen triple helix repeat-containing protein 1. (217 aa)
	IFT80	Intraflagellar transport protein 80 homolog. (777 aa)
	FZD3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa)
	NLK	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (529 aa)
	DVL3	Segment polarity protein dishevelled homolog DVL-3 isoform X1. (685 aa)
	MAGI2	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2. (767 aa)
	CELSR2	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2649 aa)
	VANGL2	Vang-like protein. (521 aa)
	PRICKLE1	Prickle-like protein 1. (831 aa)
	PTK7	Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (297 aa)
	SMURF1	E3 ubiquitin-protein ligase. (757 aa)
	ROR1	Inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
	CELSR3	Cadherin EGF LAG seven-pass G-type receptor 3. (3195 aa)
	ARHGEF19	LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 19. (784 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
	ENSTSYP00000021210	annotation not available (503 aa)
	LOC103250886	Segment polarity protein dishevelled homolog DVL-1-like. (373 aa)
	FZD4	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (507 aa)
	PRICKLE2	Prickle-like protein 2. (847 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	MED12	Mediator of RNA polymerase II transcription subunit 12 isoform X1. (2127 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
	SFRP2	Secreted frizzled-related protein 2. (301 aa)
	DAAM1	Disheveled-associated activator of morphogenesis 1 isoform X1. (1078 aa)
	DVL2	Segment polarity protein dishevelled homolog DVL-2 isoform X1. (736 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	GRHL3	Grainyhead-like protein 3 homolog isoform X1. (610 aa)
	CCDC88C	Protein Daple. (1876 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF19	DAAM1	ENSTSYP00000018834	ENSTSYP00000027504	LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 19.	Disheveled-associated activator of morphogenesis 1 isoform X1.	0.597
CCDC88C	DVL2	ENSTSYP00000034997	ENSTSYP00000030749	Protein Daple.	Segment polarity protein dishevelled homolog DVL-2 isoform X1.	0.559
CCDC88C	DVL3	ENSTSYP00000034997	ENSTSYP00000008405	Protein Daple.	Segment polarity protein dishevelled homolog DVL-3 isoform X1.	0.500
CCDC88C	LOC103250886	ENSTSYP00000034997	ENSTSYP00000021283	Protein Daple.	Segment polarity protein dishevelled homolog DVL-1-like.	0.745
CELSR1	DAAM1	ENSTSYP00000004850	ENSTSYP00000027504	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Disheveled-associated activator of morphogenesis 1 isoform X1.	0.476
CELSR1	DVL2	ENSTSYP00000004850	ENSTSYP00000030749	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Segment polarity protein dishevelled homolog DVL-2 isoform X1.	0.504
CELSR1	FZD3	ENSTSYP00000004850	ENSTSYP00000007982	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.701
CELSR1	FZD4	ENSTSYP00000004850	ENSTSYP00000022751	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.466
CELSR1	FZD6	ENSTSYP00000004850	ENSTSYP00000002576	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.705
CELSR1	LOC103250886	ENSTSYP00000004850	ENSTSYP00000021283	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Segment polarity protein dishevelled homolog DVL-1-like.	0.500
CELSR1	PRICKLE1	ENSTSYP00000004850	ENSTSYP00000014334	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle-like protein 1.	0.638
CELSR1	PRICKLE2	ENSTSYP00000004850	ENSTSYP00000023054	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle-like protein 2.	0.592
CELSR1	PTK7	ENSTSYP00000004850	ENSTSYP00000012155	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.462
CELSR1	SFRP2	ENSTSYP00000004850	ENSTSYP00000026394	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Secreted frizzled-related protein 2.	0.466
CELSR1	VANGL1	ENSTSYP00000004850	ENSTSYP00000003229	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.742
CELSR1	VANGL2	ENSTSYP00000004850	ENSTSYP00000015452	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.742
CELSR2	FZD3	ENSTSYP00000017442	ENSTSYP00000007982	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.562
CELSR2	FZD4	ENSTSYP00000017442	ENSTSYP00000022751	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.466
CELSR2	FZD6	ENSTSYP00000017442	ENSTSYP00000002576	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.568
CELSR2	PRICKLE1	ENSTSYP00000017442	ENSTSYP00000014334	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family.	Prickle-like protein 1.	0.468