(6 nodes) ERBB4-ERBB4 signaling pathway network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EREG	Proepiregulin. (167 aa)
	NRG3	Pro-neuregulin-3, membrane-bound isoform isoform X2. (344 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1280 aa)
	BTC	Probetacellulin. (178 aa)
	NRG4	Pro-neuregulin-4, membrane-bound isoform. (116 aa)
	NRG1	Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTC	ERBB4	ENSTSYP00000001351	ENSTSYP00000006840	Probetacellulin.	Receptor protein-tyrosine kinase.	0.949
BTC	EREG	ENSTSYP00000001351	ENSTSYP00000004778	Probetacellulin.	Proepiregulin.	0.815
BTC	NRG1	ENSTSYP00000001351	ENSTSYP00000027811	Probetacellulin.	Pro-neuregulin-1, membrane-bound isoform isoform X3.	0.735
BTC	NRG4	ENSTSYP00000001351	ENSTSYP00000004669	Probetacellulin.	Pro-neuregulin-4, membrane-bound isoform.	0.431
ERBB4	BTC	ENSTSYP00000006840	ENSTSYP00000001351	Receptor protein-tyrosine kinase.	Probetacellulin.	0.949
ERBB4	EREG	ENSTSYP00000006840	ENSTSYP00000004778	Receptor protein-tyrosine kinase.	Proepiregulin.	0.975
ERBB4	NRG1	ENSTSYP00000006840	ENSTSYP00000027811	Receptor protein-tyrosine kinase.	Pro-neuregulin-1, membrane-bound isoform isoform X3.	0.996
ERBB4	NRG3	ENSTSYP00000006840	ENSTSYP00000006369	Receptor protein-tyrosine kinase.	Pro-neuregulin-3, membrane-bound isoform isoform X2.	0.922
ERBB4	NRG4	ENSTSYP00000006840	ENSTSYP00000004669	Receptor protein-tyrosine kinase.	Pro-neuregulin-4, membrane-bound isoform.	0.948
EREG	BTC	ENSTSYP00000004778	ENSTSYP00000001351	Proepiregulin.	Probetacellulin.	0.815
EREG	ERBB4	ENSTSYP00000004778	ENSTSYP00000006840	Proepiregulin.	Receptor protein-tyrosine kinase.	0.975
EREG	NRG1	ENSTSYP00000004778	ENSTSYP00000027811	Proepiregulin.	Pro-neuregulin-1, membrane-bound isoform isoform X3.	0.684
NRG1	BTC	ENSTSYP00000027811	ENSTSYP00000001351	Pro-neuregulin-1, membrane-bound isoform isoform X3.	Probetacellulin.	0.735
NRG1	ERBB4	ENSTSYP00000027811	ENSTSYP00000006840	Pro-neuregulin-1, membrane-bound isoform isoform X3.	Receptor protein-tyrosine kinase.	0.996
NRG1	EREG	ENSTSYP00000027811	ENSTSYP00000004778	Pro-neuregulin-1, membrane-bound isoform isoform X3.	Proepiregulin.	0.684
NRG1	NRG3	ENSTSYP00000027811	ENSTSYP00000006369	Pro-neuregulin-1, membrane-bound isoform isoform X3.	Pro-neuregulin-3, membrane-bound isoform isoform X2.	0.830
NRG1	NRG4	ENSTSYP00000027811	ENSTSYP00000004669	Pro-neuregulin-1, membrane-bound isoform isoform X3.	Pro-neuregulin-4, membrane-bound isoform.	0.940
NRG3	ERBB4	ENSTSYP00000006369	ENSTSYP00000006840	Pro-neuregulin-3, membrane-bound isoform isoform X2.	Receptor protein-tyrosine kinase.	0.922
NRG3	NRG1	ENSTSYP00000006369	ENSTSYP00000027811	Pro-neuregulin-3, membrane-bound isoform isoform X2.	Pro-neuregulin-1, membrane-bound isoform isoform X3.	0.830
NRG3	NRG4	ENSTSYP00000006369	ENSTSYP00000004669	Pro-neuregulin-3, membrane-bound isoform isoform X2.	Pro-neuregulin-4, membrane-bound isoform.	0.879