STRINGSTRING
F2 F2 CST11 CST11 IL6R IL6R SELP SELP COCH COCH MR1 MR1 IL12A IL12A TREM1 TREM1 NOD1 NOD1 DEFB108B DEFB108B PLA2G2A PLA2G2A P2RX7 P2RX7 LGALS4 LGALS4 COLEC12 COLEC12 PRKD1 PRKD1 PI3 PI3 CTSG CTSG PGLYRP4 PGLYRP4 LOC110596296 LOC110596296 RPL30 RPL30 MAVS MAVS LBP LBP TLR4 TLR4 FGB FGB LOC103266290 LOC103266290 OAS1 OAS1 CXCL13 CXCL13 SFTPD SFTPD ENSTSYP00000004208 ENSTSYP00000004208 GSDMD GSDMD CD160 CD160 PGLYRP3 PGLYRP3 ROMO1 ROMO1 IL10 IL10 ENSTSYP00000005302 ENSTSYP00000005302 DEFB116 DEFB116 RIPK2 RIPK2 LOC103253975 LOC103253975 LPO LPO AKIRIN2 AKIRIN2 LOC110596297 LOC110596297 DEFB125 DEFB125 IL23R IL23R KLRK1 KLRK1 LALBA LALBA ENSTSYP00000006680 ENSTSYP00000006680 SEH1L SEH1L PRKCD PRKCD PLA2G6 PLA2G6 CARD9 CARD9 MYD88 MYD88 PYCARD PYCARD IL1B IL1B WFDC11 WFDC11 GBP7 GBP7 BPI BPI DEFB134 DEFB134 LOC103259375 LOC103259375 ADAM17 ADAM17 CUNH10orf99 CUNH10orf99 TLR3 TLR3 OAS3 OAS3 OAS2 OAS2 EPHA2 EPHA2 ENSTSYP00000008894 ENSTSYP00000008894 ENSTSYP00000008916 ENSTSYP00000008916 S100A8 S100A8 MBL2 MBL2 S100A12 S100A12 JCHAIN JCHAIN DEFB114 DEFB114 DEFB113 DEFB113 ZG16 ZG16 DEFB124 DEFB124 DEFB123 DEFB123 TMF1 TMF1 IL17A IL17A WFDC10A WFDC10A AICDA AICDA LTF LTF SLPI SLPI SHC1 SHC1 TSLP TSLP WFDC2 WFDC2 IL7R IL7R STAB1 STAB1 STAB2 STAB2 BPIFC BPIFC LYZ LYZ NOTCH2 NOTCH2 DEFB119 DEFB119 CRP CRP DEFB128 DEFB128 TNFSF8 TNFSF8 LYST LYST DEFB1 DEFB1 BPIFA1 BPIFA1 ANXA3 ANXA3 LYZL6 LYZL6 FGA FGA WFDC9 WFDC9 GBP4 GBP4 FAU FAU GALP GALP LEAP2 LEAP2 PGLYRP1 PGLYRP1 IL27RA IL27RA PGLYRP2 PGLYRP2 ENSTSYP00000013827 ENSTSYP00000013827 HAVCR2 HAVCR2 ENSTSYP00000014000 ENSTSYP00000014000 ENSTSYP00000014082 ENSTSYP00000014082 ISG15 ISG15 ENSTSYP00000014579 ENSTSYP00000014579 SLC11A1 SLC11A1 TREM2 TREM2 BPIFA2 BPIFA2 IRF8 IRF8 FGR FGR CHGA CHGA NR1H4 NR1H4 RPL39 RPL39 IL23A IL23A CD36 CD36 ZNFX1 ZNFX1 LOC103250340 LOC103250340 ENSTSYP00000017135 ENSTSYP00000017135 SCNN1B SCNN1B ADGRB1 ADGRB1 ACP5 ACP5 NOD2 NOD2 SYK SYK RNF31 RNF31 RNF213 RNF213 ENSTSYP00000017967 ENSTSYP00000017967 RAB1A RAB1A ADAMTS5 ADAMTS5 TBK1 TBK1 H2BC11 H2BC11 SPON2 SPON2 LOC103265819 LOC103265819 HAMP HAMP ENSTSYP00000020578 ENSTSYP00000020578 S100A14 S100A14 LYPD8 LYPD8 ENSTSYP00000021724 ENSTSYP00000021724 GNLY GNLY DEFB136 DEFB136 ENSTSYP00000022646 ENSTSYP00000022646 TIRAP TIRAP DEFB135 DEFB135 LOC103259954 LOC103259954 WFDC13 WFDC13 ENSTSYP00000024068 ENSTSYP00000024068 PLA2G1B PLA2G1B NLRC4 NLRC4 MORN5 MORN5 DEFB110 DEFB110 SHARPIN SHARPIN ANKRD17 ANKRD17 ENSTSYP00000025895 ENSTSYP00000025895 TAC1 TAC1 RBCK1 RBCK1 TNF TNF TNFRSF1A TNFRSF1A SPACA3 SPACA3 TF TF SERPINE1 SERPINE1 LCN2 LCN2 ENSTSYP00000028986 ENSTSYP00000028986 DHX15 DHX15 NAIP NAIP DEFB115 DEFB115 GSDMA GSDMA LYG2 LYG2 CALCA CALCA S100A9 S100A9 RAB14 RAB14 LOC110594416 LOC110594416 LTA LTA PPP1R11 PPP1R11 CAMP CAMP ENSTSYP00000031727 ENSTSYP00000031727 PPBP PPBP ENSTSYP00000032235 ENSTSYP00000032235 EPX EPX ENSTSYP00000032364 ENSTSYP00000032364 C5AR1 C5AR1 NLRP3 NLRP3 ENSTSYP00000032813 ENSTSYP00000032813 DMBT1 DMBT1 UMOD UMOD DROSHA DROSHA ENSTSYP00000034010 ENSTSYP00000034010 DEFB121 DEFB121 TUSC2 TUSC2 ENSTSYP00000034265 ENSTSYP00000034265 AQP1 AQP1 IL18 IL18 MPO MPO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
CST11Cystatin-11. (138 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
SELPP-selectin. (830 aa)
COCHCochlin isoform X1. (550 aa)
MR1Major histocompatibility complex class I-related gene protein isoform X1; Belongs to the MHC class I family. (341 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
TREM1Triggering receptor expressed on myeloid cells 1. (225 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
DEFB108BBeta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (73 aa)
PLA2G2APhospholipase A(2). (144 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
LGALS4Galectin. (321 aa)
COLEC12Collectin-12. (722 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
PI3Elafin. (115 aa)
CTSGCathepsin G-like; Belongs to the peptidase S1 family. (256 aa)
PGLYRP4Peptidoglycan recognition protein 4. (373 aa)
LOC110596296Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (70 aa)
RPL3060S ribosomal protein L30 isoform X1. (115 aa)
MAVSMitochondrial antiviral-signaling protein. (521 aa)
LBPLipopolysaccharide-binding protein. (481 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (840 aa)
FGBFibrinogen beta chain isoform X1. (492 aa)
LOC103266290Protein S100-A7-like. (99 aa)
OAS12'-5'-oligoadenylate synthase 1 isoform X1. (349 aa)
CXCL13C-X-C motif chemokine 13. (109 aa)
SFTPDPulmonary surfactant-associated protein D. (374 aa)
ENSTSYP00000004208annotation not available (62 aa)
GSDMDgasdermin-D. (529 aa)
CD160CD160 antigen isoform X2. (181 aa)
PGLYRP3Peptidoglycan recognition protein 3 isoform X1. (341 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
IL10Interleukin-10. (178 aa)
ENSTSYP00000005302annotation not available (101 aa)
DEFB116Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (101 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2 isoform X1. (539 aa)
LOC103253975Eppin-like. (134 aa)
LPOLactoperoxidase isoform X2. (653 aa)
AKIRIN2Akirin-2. (172 aa)
LOC110596297Beta-defensin 103-like. (66 aa)
DEFB125Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (141 aa)
IL23RInterleukin-23 receptor. (628 aa)
KLRK1NKG2-D type II integral membrane protein-like. (173 aa)
LALBAAlpha-lactalbumin; Belongs to the glycosyl hydrolase 22 family. (142 aa)
ENSTSYP00000006680annotation not available (255 aa)
SEH1LNucleoporin SEH1 isoform X2; Belongs to the WD repeat SEC13 family. (360 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X1. (807 aa)
CARD9Caspase recruitment domain-containing protein 9. (541 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
WFDC11Protein WFDC11. (85 aa)
GBP7Guanylate-binding protein 7-like isoform X1. (614 aa)
BPIBactericidal permeability-increasing protein. (508 aa)
DEFB134Beta-defensin 134. (65 aa)
LOC103259375High affinity immunoglobulin gamma Fc receptor I-like isoform X1. (371 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (824 aa)
CUNH10orf99Secreted protein C10orf99 homolog. (78 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
OAS32'-5'-oligoadenylate synthase 3. (1082 aa)
OAS22'-5'-oligoadenylate synthase 2-like. (710 aa)
EPHA2LOW QUALITY PROTEIN: ephrin type-A receptor 2. (917 aa)
ENSTSYP00000008894annotation not available (139 aa)
ENSTSYP00000008916annotation not available (91 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
MBL2Mannose-binding protein C. (247 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
JCHAINImmunoglobulin J chain. (160 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
DEFB113Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
ZG16Zymogen granule membrane protein 16. (167 aa)
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa)
DEFB123Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
TMF1TATA element modulatory factor isoform X1. (1093 aa)
IL17Ainterleukin-17A. (152 aa)
WFDC10AWAP four-disulfide core domain protein 10A. (82 aa)
AICDASingle-stranded DNA cytosine deaminase. (198 aa)
LTFLactotransferrin isoform X1; Belongs to the transferrin family. (710 aa)
SLPIAntileukoproteinase. (132 aa)
SHC1SHC-transforming protein 1 isoform X1. (474 aa)
TSLPThymic stromal lymphopoietin. (291 aa)
WFDC2WAP four-disulfide core domain protein 2. (124 aa)
IL7RInterleukin-7 receptor subunit alpha. (459 aa)
STAB1Stabilin-1. (2571 aa)
STAB2Stabilin-2. (2166 aa)
BPIFCBPI fold-containing family C protein. (507 aa)
LYZLysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. (148 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2211 aa)
DEFB119Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
CRPPentaxin. (225 aa)
DEFB128Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (94 aa)
TNFSF8Tumor necrosis factor ligand superfamily member 8; Belongs to the tumor necrosis factor family. (233 aa)
LYSTLysosomal-trafficking regulator. (3802 aa)
DEFB1Beta-defensin 1. (67 aa)
BPIFA1BPI fold-containing family A member 1. (252 aa)
ANXA3Annexin. (323 aa)
LYZL6Lysozyme-like protein 6; Belongs to the glycosyl hydrolase 22 family. (148 aa)
FGAFibrinogen alpha chain. (872 aa)
WFDC9Protein WFDC9. (87 aa)
GBP4Guanylate-binding protein 4-like. (639 aa)
FAU40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (133 aa)
GALPGalanin-like peptide. (114 aa)
LEAP2Liver-expressed antimicrobial peptide 2. (77 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (194 aa)
IL27RALOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha. (441 aa)
PGLYRP2N-acetylmuramoyl-L-alanine amidase. (574 aa)
ENSTSYP00000013827annotation not available (125 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (290 aa)
ENSTSYP00000014000annotation not available (196 aa)
ENSTSYP00000014082annotation not available (103 aa)
ISG15Ubiquitin-like protein ISG15. (165 aa)
ENSTSYP00000014579annotation not available (98 aa)
SLC11A1Natural resistance-associated macrophage protein 1 isoform X1. (522 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
BPIFA2BPI fold-containing family A member 2. (249 aa)
IRF8Interferon regulatory factor 8. (421 aa)
FGRTyrosine-protein kinase. (526 aa)
CHGAchromogranin-A isoform X4. (303 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
RPL3960S ribosomal protein L39. (51 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
ZNFX1NFX1-type zinc finger-containing protein 1. (1917 aa)
LOC103250340Sperm acrosome-associated protein 5-like; Belongs to the glycosyl hydrolase 22 family. (159 aa)
ENSTSYP00000017135annotation not available (81 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (648 aa)
ADGRB1Brain-specific angiogenesis inhibitor 1. (1462 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1040 aa)
SYKTyrosine-protein kinase. (634 aa)
RNF31E3 ubiquitin-protein ligase RNF31 isoform X1. (1073 aa)
RNF213E3 ubiquitin-protein ligase RNF213. (3828 aa)
ENSTSYP00000017967annotation not available (148 aa)
RAB1ARas-related protein Rab-1A. (210 aa)
ADAMTS5A disintegrin and metalloproteinase with thrombospondin motifs 5. (930 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
SPON2Spondin-2. (332 aa)
LOC103265819LOW QUALITY PROTEIN: placenta-specific gene 8 protein-like. (101 aa)
HAMPHepcidin. (84 aa)
ENSTSYP00000020578annotation not available (98 aa)
S100A14Protein S100-A14; Belongs to the S-100 family. (104 aa)
LYPD8ly6/PLAUR domain-containing protein 8. (228 aa)
ENSTSYP00000021724annotation not available (61 aa)
GNLYGranulysin. (176 aa)
DEFB136Beta-defensin 136. (78 aa)
ENSTSYP00000022646annotation not available (51 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein isoform X1. (228 aa)
DEFB135Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (77 aa)
LOC103259954Histone H2B; Belongs to the histone H2B family. (126 aa)
WFDC13WAP four-disulfide core domain protein 13. (93 aa)
ENSTSYP00000024068annotation not available (175 aa)
PLA2G1BPhospholipase A(2). (147 aa)
NLRC4NLR family CARD domain-containing protein 4. (1023 aa)
MORN5MORN repeat-containing protein 5 isoform X1. (172 aa)
DEFB110Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (62 aa)
SHARPINLOW QUALITY PROTEIN: sharpin. (375 aa)
ANKRD17Ankyrin repeat domain-containing protein 17. (2493 aa)
ENSTSYP00000025895annotation not available (102 aa)
TAC1Tachykinin precursor 1. (130 aa)
RBCK1ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1. (510 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (183 aa)
SPACA3LOW QUALITY PROTEIN: sperm acrosome membrane-associated protein 3; Belongs to the glycosyl hydrolase 22 family. (163 aa)
TFLOW QUALITY PROTEIN: serotransferrin-like. (697 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
LCN2Neutrophil gelatinase-associated lipocalin; Belongs to the calycin superfamily. Lipocalin family. (198 aa)
ENSTSYP00000028986annotation not available (137 aa)
DHX15pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15. (795 aa)
NAIPBaculoviral IAP repeat-containing protein 1. (1405 aa)
DEFB115Defensin beta 115. (86 aa)
GSDMAgasdermin-A. (446 aa)
LYG2Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family. (191 aa)
CALCACalcitonin isoform X2. (142 aa)
S100A9Protein S100; Belongs to the S-100 family. (133 aa)
RAB14Ras-related protein Rab-14 isoform X3. (215 aa)
LOC110594416Beta-defensin 130-like. (79 aa)
LTALymphotoxin-alpha; Belongs to the tumor necrosis factor family. (205 aa)
PPP1R11Protein phosphatase 1 regulatory subunit 11. (126 aa)
CAMPCathelicidin antimicrobial peptide. (173 aa)
ENSTSYP00000031727annotation not available (66 aa)
PPBPC-X-C motif chemokine. (128 aa)
ENSTSYP00000032235annotation not available (79 aa)
EPXEosinophil peroxidase. (713 aa)
ENSTSYP00000032364annotation not available (85 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1037 aa)
ENSTSYP00000032813annotation not available (132 aa)
DMBT1Deleted in malignant brain tumors 1 protein. (1855 aa)
UMODUromodulin. (687 aa)
DROSHARibonuclease 3. (232 aa)
ENSTSYP00000034010annotation not available (126 aa)
DEFB121Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (75 aa)
TUSC2Tumor suppressor candidate 2 isoform X2. (110 aa)
ENSTSYP00000034265annotation not available (129 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (179 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
MPOMyeloperoxidase isoform X1. (744 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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