30 items (Carlito syrichta) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	BRCA2	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3391 aa)
	EP300	Histone acetyltransferase p300. (2174 aa)
	TOPORS	E3 ubiquitin-protein ligase Topors isoform X1. (1044 aa)
	BAG6	Large proline-rich protein BAG6 isoform X1. (1162 aa)
	USP28	Ubiquitin carboxyl-terminal hydrolase 28 isoform X4; Belongs to the peptidase C19 family. (1077 aa)
	SHISA5	Protein shisa-5 isoform X1. (235 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	NUPR1	Nuclear protein 1. (99 aa)
	HIPK2	Homeodomain-interacting protein kinase 2 isoform X1. (1198 aa)
	ATAD5	ATPase family AAA domain-containing protein 5-like. (1204 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (925 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (729 aa)
	AEN	Apoptosis-enhancing nuclease. (325 aa)
	ELL3	RNA polymerase II elongation factor ELL3. (394 aa)
	PML	Protein PML. (885 aa)
	PHLDA3	Pleckstrin homology like domain family A member 3. (127 aa)
	TMEM109	Transmembrane protein 109. (244 aa)
	HIPK1	Homeodomain-interacting protein kinase 1 isoform X1. (1210 aa)
	ENSTSYP00000018602	annotation not available (632 aa)
	ENSTSYP00000020409	annotation not available (369 aa)
	ENSTSYP00000022986	annotation not available (803 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (637 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
	DDIT4	DNA damage-inducible transcript 4 protein isoform X1. (231 aa)
	ENSTSYP00000024826	annotation not available (506 aa)
	CHEK2	Serine/threonine-protein kinase Chk2 isoform X1. (582 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (690 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (164 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (556 aa)
	SNW1	SNW domain-containing protein 1 isoform X2. (536 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	PHLDA3	ENSTSYP00000011389	ENSTSYP00000014608	Apoptosis-enhancing nuclease.	Pleckstrin homology like domain family A member 3.	0.572
ATAD5	BRCA2	ENSTSYP00000009057	ENSTSYP00000000441	ATPase family AAA domain-containing protein 5-like.	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	0.786
ATAD5	CHEK2	ENSTSYP00000009057	ENSTSYP00000025718	ATPase family AAA domain-containing protein 5-like.	Serine/threonine-protein kinase Chk2 isoform X1.	0.730
ATAD5	ENSTSYP00000022986	ENSTSYP00000009057	ENSTSYP00000022986	ATPase family AAA domain-containing protein 5-like.	annotation not available	0.472
ATAD5	MSH2	ENSTSYP00000009057	ENSTSYP00000009171	ATPase family AAA domain-containing protein 5-like.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.472
BRCA2	ATAD5	ENSTSYP00000000441	ENSTSYP00000009057	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	ATPase family AAA domain-containing protein 5-like.	0.786
BRCA2	CHEK2	ENSTSYP00000000441	ENSTSYP00000025718	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Serine/threonine-protein kinase Chk2 isoform X1.	0.913
BRCA2	ENSTSYP00000022986	ENSTSYP00000000441	ENSTSYP00000022986	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	annotation not available	0.676
BRCA2	MSH2	ENSTSYP00000000441	ENSTSYP00000009171	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.676
BRCA2	TP53	ENSTSYP00000000441	ENSTSYP00000023752	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.971
BRCA2	TP63	ENSTSYP00000000441	ENSTSYP00000025741	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.625
BRCA2	TP73	ENSTSYP00000000441	ENSTSYP00000023546	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.625
CDKN1A	CHEK2	ENSTSYP00000027188	ENSTSYP00000025718	Cyclin-dependent kinase inhibitor 1.	Serine/threonine-protein kinase Chk2 isoform X1.	0.508
CDKN1A	EP300	ENSTSYP00000027188	ENSTSYP00000001158	Cyclin-dependent kinase inhibitor 1.	Histone acetyltransferase p300.	0.795
CDKN1A	SIRT1	ENSTSYP00000027188	ENSTSYP00000011158	Cyclin-dependent kinase inhibitor 1.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.427
CDKN1A	TP53	ENSTSYP00000027188	ENSTSYP00000023752	Cyclin-dependent kinase inhibitor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.994
CDKN1A	TP63	ENSTSYP00000027188	ENSTSYP00000025741	Cyclin-dependent kinase inhibitor 1.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.863
CDKN1A	TP73	ENSTSYP00000027188	ENSTSYP00000023546	Cyclin-dependent kinase inhibitor 1.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.879
CHEK2	ATAD5	ENSTSYP00000025718	ENSTSYP00000009057	Serine/threonine-protein kinase Chk2 isoform X1.	ATPase family AAA domain-containing protein 5-like.	0.730
CHEK2	BRCA2	ENSTSYP00000025718	ENSTSYP00000000441	Serine/threonine-protein kinase Chk2 isoform X1.	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	0.913