STRINGSTRING
AIFM1 AIFM1 ARL6IP1 ARL6IP1 MGMT MGMT ENSTSYP00000029279 ENSTSYP00000029279 NAIP NAIP FIS1 FIS1 SMAD3 SMAD3 CD27 CD27 ENSTSYP00000030075 ENSTSYP00000030075 BCL2L10 BCL2L10 NLRP12 NLRP12 S100A9 S100A9 CASP8 CASP8 MYC MYC AKT1 AKT1 LOC103256667 LOC103256667 LOC103267945 LOC103267945 RPS6KA1 RPS6KA1 FABP1 FABP1 TNFAIP8 TNFAIP8 MICAL1 MICAL1 ADORA2A ADORA2A FNIP1 FNIP1 CDKN2D CDKN2D P2RX1 P2RX1 KLF4 KLF4 BAX BAX NLRP3 NLRP3 ENSTSYP00000032793 ENSTSYP00000032793 DAP DAP BOK BOK SRC SRC PMAIP1 PMAIP1 HIP1 HIP1 NGFR NGFR CCN2 CCN2 SLC11A2 SLC11A2 HTRA2 HTRA2 ATP2A3 ATP2A3 ENSTSYP00000034326 ENSTSYP00000034326 EPHA7 EPHA7 ALOX12 ALOX12 LOC103251546 LOC103251546 AQP1 AQP1 CASP10 CASP10 JAK2 JAK2 ST18 ST18 SH3RF1 SH3RF1 S100A8 S100A8 VCP VCP LOC103267233 LOC103267233 RPS3 RPS3 SLC1A1 SLC1A1 ENSTSYP00000007785 ENSTSYP00000007785 ENSTSYP00000007331 ENSTSYP00000007331 DNAJA3 DNAJA3 PYCARD PYCARD ANP32B ANP32B CARD9 CARD9 MRTFA MRTFA RET RET FAS FAS DHCR24 DHCR24 LOC103269416 LOC103269416 LOC103263247 LOC103263247 CASP8AP2 CASP8AP2 EIF2AK3 EIF2AK3 CTSH CTSH ACER2 ACER2 CAAP1 CAAP1 NODAL NODAL CCN1 CCN1 GSN GSN LAPTM5 LAPTM5 ROBO1 ROBO1 SERPINB9 SERPINB9 LOC103259286 LOC103259286 CASP9 CASP9 THBS1 THBS1 LOC103269310 LOC103269310 XIAP XIAP MALT1 MALT1 IFT57 IFT57 CLEC7A CLEC7A BCL2L12 BCL2L12 MMP9 MMP9 IFI6 IFI6 NOD1 NOD1 KIAA0141 KIAA0141 MAP3K5 MAP3K5 ACVR1C ACVR1C LOC103274909 LOC103274909 TNF TNF BAK1 BAK1 TRIAP1 TRIAP1 ENSTSYP00000027026 ENSTSYP00000027026 SFRP2 SFRP2 WNT3A WNT3A PDCD2 PDCD2 ENSTSYP00000025886 ENSTSYP00000025886 MT3 MT3 TP63 TP63 DIABLO DIABLO LOC103256196 LOC103256196 ENSTSYP00000024578 ENSTSYP00000024578 REST REST SFN SFN APAF1 APAF1 NLRC4 NLRC4 MUL1 MUL1 LOC103255326 LOC103255326 POR POR PIH1D1 PIH1D1 HIP1R HIP1R LCK LCK ENSTSYP00000021932 ENSTSYP00000021932 ENSTSYP00000021856 ENSTSYP00000021856 PPM1F PPM1F ENSTSYP00000021551 ENSTSYP00000021551 ENSTSYP00000021424 ENSTSYP00000021424 BID BID RFFL RFFL TFAP4 TFAP4 LOC110596190 LOC110596190 LOC103252255 LOC103252255 CD44 CD44 BEX3 BEX3 GRAMD4 GRAMD4 ENSTSYP00000019529 ENSTSYP00000019529 USP47 USP47 VIL1 VIL1 TNFSF14 TNFSF14 BCL10 BCL10 HSF1 HSF1 ENSTSYP00000018615 ENSTSYP00000018615 NLE1 NLE1 ENSTSYP00000018559 ENSTSYP00000018559 CDKN2A CDKN2A LAMTOR5 LAMTOR5 PRDX5 PRDX5 NR4A1 NR4A1 BIRC5 BIRC5 TNFSF10 TNFSF10 SYK SYK NOL3 NOL3 MAP2K5 MAP2K5 ARL6IP5 ARL6IP5 ENSTSYP00000017154 ENSTSYP00000017154 FAM162A FAM162A GAS6 GAS6 BIRC3 BIRC3 RNF34 RNF34 DPEP1 DPEP1 UACA UACA PARK7 PARK7 ENSTSYP00000015305 ENSTSYP00000015305 AVP AVP ENSTSYP00000015055 ENSTSYP00000015055 PML PML BIRC7 BIRC7 ENSTSYP00000014192 ENSTSYP00000014192 DAPK1 DAPK1 MTCH1 MTCH1 IL9 IL9 INTS1 INTS1 F3 F3 DLC1 DLC1 HGF HGF NDUFA13 NDUFA13 BCL2L13 BCL2L13 RPS6KA3 RPS6KA3 PTGS2 PTGS2 CASP2 CASP2 SIRT1 SIRT1 TNFSF15 TNFSF15 XDH XDH PAK2 PAK2 BCL2L11 BCL2L11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIFM1Apoptosis-inducing factor 1, mitochondrial isoform X1. (613 aa)
ARL6IP1ADP-ribosylation factor-like protein 6-interacting protein 1. (203 aa)
MGMTmethylated-DNA--protein-cysteine methyltransferase. (188 aa)
ENSTSYP00000029279annotation not available (107 aa)
NAIPBaculoviral IAP repeat-containing protein 1. (1405 aa)
FIS1Mitochondrial fission 1 protein. (128 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CD27CD27 antigen. (219 aa)
ENSTSYP00000030075annotation not available (540 aa)
BCL2L10Bcl-2-like protein 10. (195 aa)
NLRP12NACHT, LRR and PYD domains-containing protein 12 isoform X1. (1064 aa)
S100A9Protein S100; Belongs to the S-100 family. (133 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (521 aa)
MYCMyc proto-oncogene protein. (376 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
LOC103256667Hepatocyte nuclear factor 1-alpha isoform X2. (227 aa)
LOC103267945Receptor of activated protein C kinase 1-like. (223 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
FABP1Fatty acid-binding protein, liver. (127 aa)
TNFAIP8Tumor necrosis factor alpha-induced protein 8 isoform X3. (209 aa)
MICAL1F-actin-methionine sulfoxide oxidase MICAL1 isoform X1. (1082 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
FNIP1Folliculin-interacting protein 1 isoform X1. (1165 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (406 aa)
KLF4Krueppel-like factor 4. (478 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1037 aa)
ENSTSYP00000032793annotation not available (555 aa)
DAPDeath-associated protein 1 isoform X2. (102 aa)
BOKBcl-2-related ovarian killer protein. (148 aa)
SRCTyrosine-protein kinase. (542 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
HIP1Huntingtin-interacting protein 1. (1008 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (333 aa)
CCN2Connective tissue growth factor. (297 aa)
SLC11A2Natural resistance-associated macrophage protein 2 isoform X2. (590 aa)
HTRA2Serine protease HTRA2, mitochondrial. (373 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1028 aa)
ENSTSYP00000034326annotation not available (235 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (1090 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
LOC103251546Baculoviral IAP repeat-containing protein 2. (310 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (179 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (471 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
ST18Suppression of tumorigenicity 18 protein. (1043 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (887 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
VCPTransitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (806 aa)
LOC103267233Caspase-1-like; Belongs to the peptidase C14A family. (291 aa)
RPS340S ribosomal protein S3 isoform X1; Belongs to the universal ribosomal protein uS3 family. (280 aa)
SLC1A1Amino acid transporter. (524 aa)
ENSTSYP00000007785annotation not available (217 aa)
ENSTSYP00000007331annotation not available (100 aa)
DNAJA3dnaJ homolog subfamily A member 3, mitochondrial isoform X1. (480 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B. (234 aa)
CARD9Caspase recruitment domain-containing protein 9. (541 aa)
MRTFAMKL/myocardin-like protein 1 isoform X1. (952 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1092 aa)
FASTumor necrosis factor receptor superfamily member 6. (333 aa)
DHCR24Delta(24)-sterol reductase. (516 aa)
LOC103269416Baculoviral IAP repeat-containing protein 2-like. (340 aa)
LOC103263247Arachidonate 12-lipoxygenase, 12S-type-like. (669 aa)
CASP8AP2CASP8-associated protein 2. (1963 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1117 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (153 aa)
CAAP1Caspase activity and apoptosis inhibitor 1. (362 aa)
NODALNodal homolog. (332 aa)
CCN1Protein CYR61. (325 aa)
GSNGelsolin isoform X1. (777 aa)
LAPTM5Lysosomal-associated transmembrane protein 5. (261 aa)
ROBO1Roundabout homolog 1. (1394 aa)
SERPINB9Serpin B9; Belongs to the serpin family. (375 aa)
LOC103259286Collagen alpha-3(IV) chain-like. (884 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (410 aa)
THBS1Thrombospondin-1. (1178 aa)
LOC103269310Egl nine homolog 3. (145 aa)
XIAPE3 ubiquitin-protein ligase XIAP. (497 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (828 aa)
IFT57Intraflagellar transport protein 57 homolog isoform X1. (429 aa)
CLEC7AC-type lectin domain family 7 member A isoform X1. (241 aa)
BCL2L12Bcl-2-like protein 12. (299 aa)
MMP9Matrix metalloproteinase-9. (710 aa)
IFI6Interferon alpha-inducible protein 6 isoform X1. (142 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
KIAA0141Death ligand signal enhancer. (517 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1329 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
LOC103274909Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
TRIAP1TP53-regulated inhibitor of apoptosis 1. (76 aa)
ENSTSYP00000027026annotation not available (105 aa)
SFRP2Secreted frizzled-related protein 2. (301 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PDCD2Programmed cell death protein 2 isoform X1. (344 aa)
ENSTSYP00000025886annotation not available (391 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (111 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (690 aa)
DIABLODiablo homolog, mitochondrial isoform X1. (237 aa)
LOC103256196LOW QUALITY PROTEIN: receptor of activated protein C kinase 1-like. (305 aa)
ENSTSYP00000024578annotation not available (73 aa)
RESTRE1-silencing transcription factor. (339 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1246 aa)
NLRC4NLR family CARD domain-containing protein 4. (1023 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
LOC103255326Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (678 aa)
PIH1D1PIH1 domain-containing protein 1. (260 aa)
HIP1RHuntingtin-interacting protein 1-related protein. (1059 aa)
LCKTyrosine-protein kinase. (524 aa)
ENSTSYP00000021932annotation not available (243 aa)
ENSTSYP00000021856annotation not available (88 aa)
PPM1FProtein phosphatase 1F. (448 aa)
ENSTSYP00000021551annotation not available (370 aa)
ENSTSYP00000021424annotation not available (514 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X1. (363 aa)
TFAP4Transcription factor AP-4. (337 aa)
LOC110596190Cytochrome c, somatic-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (108 aa)
LOC103252255Paired box protein Pax-2-like. (232 aa)
CD44CD44 antigen. (219 aa)
BEX3Protein BEX3 isoform X2. (112 aa)
GRAMD4GRAM domain-containing protein 4. (578 aa)
ENSTSYP00000019529annotation not available (104 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1375 aa)
VIL1Villin-1. (828 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14. (217 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
HSF1Heat shock factor protein 1 isoform X2. (523 aa)
ENSTSYP00000018615annotation not available (270 aa)
NLE1Notchless protein homolog 1 isoform X1. (486 aa)
ENSTSYP00000018559annotation not available (259 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A. (171 aa)
LAMTOR5Ragulator complex protein LAMTOR5. (91 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (188 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1 isoform X1. (631 aa)
BIRC5Baculoviral IAP repeat-containing protein 5 isoform X1. (142 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10 isoform X2. (101 aa)
SYKTyrosine-protein kinase. (634 aa)
NOL3Nucleolar protein 3 isoform X2. (211 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X1; Belongs to the protein kinase superfamily. (448 aa)
ARL6IP5PRA1 family protein. (188 aa)
ENSTSYP00000017154annotation not available (93 aa)
FAM162AProtein FAM162A. (155 aa)
GAS6Growth arrest-specific protein 6. (440 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (603 aa)
RNF34E3 ubiquitin-protein ligase RNF34 isoform X1. (494 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (410 aa)
UACALOW QUALITY PROTEIN: uveal autoantigen with coiled-coil domains and ankyrin repeats. (1403 aa)
PARK7Protein DJ-1. (189 aa)
ENSTSYP00000015305annotation not available (177 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (107 aa)
ENSTSYP00000015055annotation not available (592 aa)
PMLProtein PML. (885 aa)
BIRC7Baculoviral IAP repeat-containing protein 7. (280 aa)
ENSTSYP00000014192annotation not available (88 aa)
DAPK1Death-associated protein kinase 1 isoform X2. (1430 aa)
MTCH1Mitochondrial carrier homolog 1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
IL9Interleukin-9. (144 aa)
INTS1Integrator complex subunit 1. (2187 aa)
F3Tissue factor. (294 aa)
DLC1Rho GTPase-activating protein 7 isoform X1. (1528 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (144 aa)
BCL2L13Bcl-2-like protein 13 isoform X1. (201 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (729 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
CASP2Caspase-2; Belongs to the peptidase C14A family. (451 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (729 aa)
TNFSF15Tumor necrosis factor ligand superfamily member 15. (251 aa)
XDHXanthine dehydrogenase/oxidase. (1333 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (200 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
Server load: low (20%) [HD]