STRINGSTRING
UBE2M UBE2M AIFM1 AIFM1 SOD2 SOD2 CNTFR CNTFR PLA2G3 PLA2G3 LGMN LGMN NRP1 NRP1 GFRAL GFRAL ABL1 ABL1 STAMBP STAMBP TFAP2D TFAP2D SIX4 SIX4 CITED1 CITED1 LOC103269310 LOC103269310 MYBL2 MYBL2 ATF2 ATF2 CASP9 CASP9 TFAP2A TFAP2A GABRB2 GABRB2 SRPK2 SRPK2 ENSTSYP00000003286 ENSTSYP00000003286 PARP1 PARP1 HRAS HRAS PAWR PAWR DNAJC5B DNAJC5B PIK3CA PIK3CA KDR KDR GCLM GCLM XRCC2 XRCC2 GBE1 GBE1 DDIT3 DDIT3 ITGA1 ITGA1 CX3CR1 CX3CR1 RETREG1 RETREG1 FOXB1 FOXB1 NDNF NDNF ZPR1 ZPR1 LOC103252070 LOC103252070 PRKN PRKN ISL1 ISL1 NUPR1 NUPR1 SLC1A1 SLC1A1 KIF14 KIF14 HIPK2 HIPK2 NTF3 NTF3 SEMA3E SEMA3E BRAF BRAF NF1 NF1 ATM ATM LANCL1 LANCL1 MSH2 MSH2 FZD9 FZD9 ANGPT1 ANGPT1 ALKBH1 ALKBH1 CTNNB1 CTNNB1 CDV3 CDV3 RAPSN RAPSN BCL2L11 BCL2L11 ITGAM ITGAM KCNB1 KCNB1 CDK5R1 CDK5R1 CHL1 CHL1 CASP2 CASP2 SARM1 SARM1 UNC5B UNC5B GDNF GDNF FAIM2 FAIM2 VPS54 VPS54 IL27RA IL27RA MAP2K7 MAP2K7 BCL2L1 BCL2L1 PRKCI PRKCI MAP2K4 MAP2K4 ENSTSYP00000014736 ENSTSYP00000014736 SLC30A10 SLC30A10 TREM2 TREM2 ENSTSYP00000015305 ENSTSYP00000015305 HIF1A HIF1A WFS1 WFS1 PARK7 PARK7 RASA1 RASA1 MAP3K12 MAP3K12 NTRK2 NTRK2 GDF5 GDF5 ADNP ADNP ROCK1 ROCK1 LOC103264685 LOC103264685 GRN GRN CDK5 CDK5 IL6ST IL6ST NFATC4 NFATC4 AGAP2 AGAP2 NAE1 NAE1 BIRC5 BIRC5 SNCB SNCB CX3CL1 CX3CL1 PPARGC1A PPARGC1A PCSK9 PCSK9 TOX3 TOX3 GRIK5 GRIK5 PTPRZ1 PTPRZ1 PLXND1 PLXND1 AXL AXL MECP2 MECP2 CORO1A CORO1A ENSTSYP00000019175 ENSTSYP00000019175 CDC34 CDC34 ENSTSYP00000019483 ENSTSYP00000019483 GRIK2 GRIK2 NR4A2 NR4A2 PINK1 PINK1 FGF20 FGF20 BARHL1 BARHL1 FGF20-2 FGF20-2 NONO NONO BDNF BDNF EGLN2 EGLN2 ASCL1 ASCL1 ENSTSYP00000022061 ENSTSYP00000022061 CCND1 CCND1 FBXW7 FBXW7 ENSTSYP00000022986 ENSTSYP00000022986 BTG2 BTG2 TP53 TP53 DLX1 DLX1 NES NES AARS AARS MAP3K11 MAP3K11 TRIM2 TRIM2 HYOU1 HYOU1 MT3 MT3 ENSTSYP00000025886 ENSTSYP00000025886 FBXW9 FBXW9 MAG MAG CLN8 CLN8 PPT1 PPT1 NTRK1 NTRK1 SOD1 SOD1 GATA3 GATA3 CPEB4 CPEB4 SYNGAP1 SYNGAP1 NGF NGF TNF TNF OXR1 OXR1 G6PD G6PD GSK3A GSK3A CLCF1 CLCF1 ENSTSYP00000029441 ENSTSYP00000029441 NAIP NAIP GCLC GCLC TFAP2B TFAP2B TGFB3 TGFB3 VSTM2L VSTM2L ADAM8 ADAM8 AMBRA1 AMBRA1 ENSTSYP00000030893 ENSTSYP00000030893 HDGF HDGF ENSTSYP00000031096 ENSTSYP00000031096 TGFB2 TGFB2 NRBP2 NRBP2 ADORA2A ADORA2A MEF2C MEF2C GABRA5 GABRA5 SIGMAR1 SIGMAR1 DNAJC5 DNAJC5 BAX BAX TERT TERT BOK BOK ENSTSYP00000033051 ENSTSYP00000033051 BACE1 BACE1 CRLF1 CRLF1 PRKCG PRKCG ATF4 ATF4 CNTF CNTF ENSTSYP00000033656 ENSTSYP00000033656 EPHA7 EPHA7 NEFL NEFL PTK2B PTK2B KDM2B KDM2B IL18 IL18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBE2MNEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
AIFM1Apoptosis-inducing factor 1, mitochondrial isoform X1. (613 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (221 aa)
CNTFRCiliary neurotrophic factor receptor subunit alpha. (372 aa)
PLA2G3Group 3 secretory phospholipase A2. (506 aa)
LGMNLegumain. (433 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (927 aa)
GFRALGDNF family receptor alpha-like. (394 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
STAMBPSTAM-binding protein. (424 aa)
TFAP2DTranscription factor AP-2-delta. (452 aa)
SIX4Homeobox protein SIX4 isoform X1. (773 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X1. (221 aa)
LOC103269310Egl nine homolog 3. (145 aa)
MYBL2Myb-related protein B. (662 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (507 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (410 aa)
TFAP2ATranscription factor AP-2-alpha. (427 aa)
GABRB2Gamma-aminobutyric acid receptor subunit beta-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
SRPK2SRSF protein kinase 2 isoform X1. (697 aa)
ENSTSYP00000003286annotation not available (388 aa)
PARP1Poly [ADP-ribose] polymerase. (919 aa)
HRASGTPase HRas isoform X6. (189 aa)
PAWRPRKC apoptosis WT1 regulator protein. (224 aa)
DNAJC5BdnaJ homolog subfamily C member 5B. (199 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GCLMGlutamate--cysteine ligase regulatory subunit. (232 aa)
XRCC2DNA repair protein XRCC2. (280 aa)
GBE11,4-alpha-glucan-branching enzyme isoform X2. (559 aa)
DDIT3DNA damage-inducible transcript 3 protein. (184 aa)
ITGA1Integrin alpha-1; Belongs to the integrin alpha chain family. (971 aa)
CX3CR1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (377 aa)
RETREG1Reticulophagy receptor FAM134B isoform X2. (354 aa)
FOXB1LOW QUALITY PROTEIN: forkhead box protein B1-like. (325 aa)
NDNFProtein NDNF. (566 aa)
ZPR1LOW QUALITY PROTEIN: zinc finger protein ZPR1. (445 aa)
LOC103252070non-POU domain-containing octamer-binding protein. (469 aa)
PRKNRBR-type E3 ubiquitin transferase. (220 aa)
ISL1Insulin gene enhancer protein ISL-1 isoform X1. (353 aa)
NUPR1Nuclear protein 1. (99 aa)
SLC1A1Amino acid transporter. (524 aa)
KIF14Kinesin-like protein KIF14 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1647 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1198 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (264 aa)
SEMA3Esemaphorin-3E isoform X1; Belongs to the semaphorin family. (735 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
NF1Neurofibromin isoform X2. (2839 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
LANCL1lanC-like protein 1. (371 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (925 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (365 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
ALKBH1Nucleic acid dioxygenase ALKBH1. (358 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
CDV3Protein CDV3 homolog isoform X2. (156 aa)
RAPSN43 kDa receptor-associated protein of the synapse. (235 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (200 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
CHL1Neural cell adhesion molecule L1-like protein isoform X1. (1223 aa)
CASP2Caspase-2; Belongs to the peptidase C14A family. (451 aa)
SARM1Sterile alpha and TIR motif-containing protein 1. (724 aa)
UNC5BNetrin receptor UNC5B. (907 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X3. (211 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (316 aa)
VPS54Vacuolar protein sorting-associated protein 54. (875 aa)
IL27RALOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha. (441 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (414 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (598 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (387 aa)
ENSTSYP00000014736annotation not available (112 aa)
SLC30A10Zinc transporter 10. (485 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
ENSTSYP00000015305annotation not available (177 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (842 aa)
WFS1Wolframin. (436 aa)
PARK7Protein DJ-1. (189 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1047 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
NTRK2BDNF/NT-3 growth factors receptor isoform X1. (553 aa)
GDF5Growth/differentiation factor 5. (499 aa)
ADNPActivity-dependent neuroprotector homeobox protein. (1101 aa)
ROCK1Rho-associated protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1367 aa)
LOC10326468543 kDa receptor-associated protein of the synapse-like. (177 aa)
GRNGranulins. (590 aa)
CDK5Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
IL6STInterleukin-6 receptor subunit beta. (917 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (930 aa)
AGAP2LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (784 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
BIRC5Baculoviral IAP repeat-containing protein 5 isoform X1. (142 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (93 aa)
CX3CL1Fractalkine isoform X2. (402 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2. (798 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (682 aa)
TOX3TOX high mobility group box family member 3. (578 aa)
GRIK5Glutamate receptor ionotropic, kainate 5. (981 aa)
PTPRZ1Receptor-type tyrosine-protein phosphatase zeta isoform X1. (2301 aa)
PLXND1plexin-D1. (55 aa)
AXLTyrosine-protein kinase receptor UFO isoform X1. (894 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (510 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
ENSTSYP00000019175annotation not available (491 aa)
CDC34Ubiquitin-conjugating enzyme E2 R1-like; Belongs to the ubiquitin-conjugating enzyme family. (223 aa)
ENSTSYP00000019483annotation not available (478 aa)
GRIK2Glutamate receptor ionotropic, kainate 2. (870 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (598 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (510 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
BARHL1barH-like 1 homeobox protein. (328 aa)
FGF20-2Fibroblast growth factor 20. (75 aa)
NONOLOW QUALITY PROTEIN: non-POU domain-containing octamer-binding protein. (453 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (328 aa)
EGLN2Egl nine homolog 2. (405 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (220 aa)
ENSTSYP00000022061annotation not available (180 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (708 aa)
ENSTSYP00000022986annotation not available (803 aa)
BTG2Protein BTG2. (163 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
DLX1Homeobox protein DLX-1. (255 aa)
NESNestin; Belongs to the intermediate filament family. (1505 aa)
AARSalanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (745 aa)
TRIM2Tripartite motif-containing protein 2 isoform X1. (772 aa)
HYOU1Hypoxia up-regulated protein 1 isoform X1. (997 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (111 aa)
ENSTSYP00000025886annotation not available (391 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
MAGMyelin-associated glycoprotein. (626 aa)
CLN8Protein CLN8. (288 aa)
PPT1Palmitoyl-protein thioesterase 1 isoform X1. (306 aa)
NTRK1High affinity nerve growth factor receptor. (721 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (436 aa)
CPEB4Cytoplasmic polyadenylation element-binding protein 4 isoform X1. (729 aa)
SYNGAP1ras/Rap GTPase-activating protein SynGAP isoform X3. (1331 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (268 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
OXR1Oxidation resistance protein 1 isoform X1. (876 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (556 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (431 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (260 aa)
ENSTSYP00000029441annotation not available (424 aa)
NAIPBaculoviral IAP repeat-containing protein 1. (1405 aa)
GCLCGlutamate--cysteine ligase catalytic subunit isoform X2. (637 aa)
TFAP2BTranscription factor AP-2-beta isoform X2. (460 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
VSTM2LV-set and transmembrane domain containing 2 like. (164 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (801 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1. (1299 aa)
ENSTSYP00000030893annotation not available (343 aa)
HDGFHepatoma-derived growth factor isoform X2. (250 aa)
ENSTSYP00000031096annotation not available (176 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NRBP2Nuclear receptor-binding protein 2 isoform X2. (499 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
GABRA5Gamma-aminobutyric acid receptor subunit alpha-5; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (134 aa)
DNAJC5dnaJ homolog subfamily C member 5 isoform X1. (198 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1078 aa)
BOKBcl-2-related ovarian killer protein. (148 aa)
ENSTSYP00000033051annotation not available (123 aa)
BACE1Beta-secretase 1 isoform X1; Belongs to the peptidase A1 family. (502 aa)
CRLF1Cytokine receptor-like factor 1. (383 aa)
PRKCGProtein kinase C. (634 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X2. (352 aa)
CNTFCiliary neurotrophic factor. (200 aa)
ENSTSYP00000033656annotation not available (345 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (1090 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (544 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
KDM2BLysine-specific demethylase 2B isoform X1. (1331 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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