STRINGSTRING
LOC103256219 LOC103256219 PTCH1 PTCH1 JAG1 JAG1 BMPR1B BMPR1B PRKD1 PRKD1 CITED1 CITED1 VEGFC VEGFC GDPD2 GDPD2 SCUBE3 SCUBE3 TNN TNN SMOC1 SMOC1 IL6R IL6R ACVR2B ACVR2B DDX5 DDX5 TWSG1 TWSG1 TRPM4 TRPM4 ENSTSYP00000029473 ENSTSYP00000029473 IGF1 IGF1 PDLIM7 PDLIM7 SMAD3 SMAD3 OSTN OSTN ENSTSYP00000030893 ENSTSYP00000030893 ENSTSYP00000031078 ENSTSYP00000031078 IL6 IL6 FBN2 FBN2 WNT4 WNT4 MEF2C MEF2C SNAI2 SNAI2 NOTCH1 NOTCH1 ID3 ID3 ATF4 ATF4 ENSTSYP00000033656 ENSTSYP00000033656 WNT10B WNT10B BMP2 BMP2 IGFBP5 IGFBP5 BMP7 BMP7 SMAD5 SMAD5 SFRP2 SFRP2 TNF TNF SUCO SUCO BMP4 BMP4 TP63 TP63 ESRRA ESRRA ACVR1 ACVR1 PTK2 PTK2 GLI1 GLI1 REST REST ZHX3 ZHX3 BMPR2 BMPR2 PPP3CA PPP3CA HDAC7 HDAC7 TMEM64 TMEM64 UCMA UCMA SUFU SUFU NOCT NOCT MEN1 MEN1 FAM20C FAM20C RORB RORB BMPR1A BMPR1A BAMBI BAMBI TNFAIP6 TNFAIP6 LOC103267910 LOC103267910 CHRD CHRD GDF10 GDF10 AXIN2 AXIN2 CTNNBIP1 CTNNBIP1 LIMD1 LIMD1 IL6ST IL6ST SEMA4D SEMA4D YAP1 YAP1 CLIC1 CLIC1 WNT7B WNT7B SMAD1 SMAD1 CDK6 CDK6 SCUBE2 SCUBE2 HGF HGF LOC103250516 LOC103250516 FBXO5 FBXO5 NPPC NPPC LTF LTF CTNNB1 CTNNB1 FGFR2 FGFR2 RASSF2 RASSF2 AREG AREG GLI3 GLI3 WDR63 WDR63 HOXA2 HOXA2 FERMT2 FERMT2 WISP1 WISP1 FNDC3B FNDC3B ACVR2A ACVR2A WWTR1 WWTR1 RANBP3L RANBP3L HEMGN HEMGN CTHRC1 CTHRC1 CCN1 CCN1 CRIM1 CRIM1 BMP6 BMP6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103256219LOW QUALITY PROTEIN: protein kinase C-binding protein NELL1-like. (404 aa)
PTCH1Protein patched homolog 1. (1318 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (480 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X1. (221 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (407 aa)
GDPD2Glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1. (552 aa)
SCUBE3Signal peptide, CUB and EGF-like domain-containing protein 3. (953 aa)
TNNtenascin-N isoform X1. (1297 aa)
SMOC1SPARC-related modular calcium-binding protein 1. (401 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (601 aa)
TWSG1Twisted gastrulation protein homolog 1. (224 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (978 aa)
ENSTSYP00000029473annotation not available (198 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
PDLIM7PDZ and LIM domain protein 7. (276 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
OSTNOsteocrin. (132 aa)
ENSTSYP00000030893annotation not available (343 aa)
ENSTSYP00000031078annotation not available (197 aa)
IL6Interleukin-6. (209 aa)
FBN2Fibrillin-2. (2912 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2339 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X2. (352 aa)
ENSTSYP00000033656annotation not available (345 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SFRP2Secreted frizzled-related protein 2. (301 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
SUCOSUN domain-containing ossification factor. (1251 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (409 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (690 aa)
ESRRASteroid hormone receptor ERR1. (409 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
GLI1LOW QUALITY PROTEIN: zinc finger protein GLI1. (1105 aa)
RESTRE1-silencing transcription factor. (339 aa)
ZHX3Zinc fingers and homeoboxes protein 3 isoform X2. (959 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (983 aa)
TMEM64Transmembrane protein 64. (119 aa)
UCMAUnique cartilage matrix-associated protein isoform X1. (138 aa)
SUFUSuppressor of fused homolog. (511 aa)
NOCTNocturnin. (314 aa)
MEN1Menin. (615 aa)
FAM20CExtracellular serine/threonine protein kinase FAM20C. (488 aa)
RORBNuclear receptor ROR-beta isoform X1. (470 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (276 aa)
LOC103267910Fibroblast growth factor receptor 2-like. (208 aa)
CHRDLOW QUALITY PROTEIN: chordin. (874 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (476 aa)
AXIN2Axin-2. (649 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
LIMD1LIM domain-containing protein 1. (674 aa)
IL6STInterleukin-6 receptor subunit beta. (917 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (733 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (326 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CDK6Cyclin-dependent kinase 6. (264 aa)
SCUBE2Signal peptide, CUB and EGF-like domain-containing protein 2. (999 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
LOC103250516Discoidin domain-containing receptor 2-like. (168 aa)
FBXO5F-box only protein 5 isoform X1. (447 aa)
NPPCC-type natriuretic peptide. (129 aa)
LTFLactotransferrin isoform X1; Belongs to the transferrin family. (710 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
FGFR2Fibroblast growth factor receptor 2 isoform X1. (615 aa)
RASSF2Ras association domain-containing protein 2. (326 aa)
AREGAmphiregulin isoform X1. (270 aa)
GLI3LOW QUALITY PROTEIN: transcriptional activator GLI3. (1533 aa)
WDR63WD repeat-containing protein 63. (895 aa)
HOXA2Homeobox protein Hox-A2. (375 aa)
FERMT2Fermitin family homolog 2. (664 aa)
WISP1WNT1-inducible-signaling pathway protein 1. (367 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1203 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
RANBP3LRan-binding protein 3-like isoform X1. (480 aa)
HEMGNHemogen. (482 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (217 aa)
CCN1Protein CYR61. (325 aa)
CRIM1Cysteine-rich motor neuron 1 protein isoform X1. (1037 aa)
BMP6Bone morphogenetic protein 6. (513 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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