STRINGSTRING
IL10RA IL10RA PRL PRL PTPRC PTPRC PTPRD PTPRD CRLF3 CRLF3 MST1 MST1 INPP5F INPP5F CENPJ CENPJ KIT KIT PIBF1 PIBF1 PARP14 PARP14 IL10 IL10 IL23R IL23R ERBB4 ERBB4 NLK NLK EGF EGF IL4 IL4 JAK2 JAK2 PPP2R1A PPP2R1A SH2B3 SH2B3 DOT1L DOT1L NF2 NF2 ENSTSYP00000019212 ENSTSYP00000019212 IL12RB1 IL12RB1 ELP2 ELP2 ENSTSYP00000023666 ENSTSYP00000023666 ENSTSYP00000024219 ENSTSYP00000024219 IL24 IL24 ENSTSYP00000026316 ENSTSYP00000026316 PRLR PRLR PIGU PIGU GH1 GH1 ENSTSYP00000029747 ENSTSYP00000029747 OCIAD2 OCIAD2 HGS HGS IL6 IL6 CAV1 CAV1 PTPN2 PTPN2 NOTCH1 NOTCH1 PTK2B PTK2B TYK2 TYK2 CDK5R1 CDK5R1 NEUROD1 NEUROD1 IL9 IL9 PPP2CA PPP2CA SOCS3 SOCS3 IL23A IL23A CDK5 CDK5 AGAP2 AGAP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL10RAInterleukin-10 receptor subunit alpha. (581 aa)
PRLProlactin. (228 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (601 aa)
PTPRDReceptor-type tyrosine-protein phosphatase delta isoform X2. (1912 aa)
CRLF3Cytokine receptor-like factor 3. (314 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
INPP5FPhosphatidylinositide phosphatase SAC2-like isoform X1. (1100 aa)
CENPJCentromere protein J. (1339 aa)
KITMast/stem cell growth factor receptor Kit; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa)
PIBF1Progesterone-induced-blocking factor 1. (756 aa)
PARP14Poly [ADP-ribose] polymerase. (1801 aa)
IL10Interleukin-10. (178 aa)
IL23RInterleukin-23 receptor. (628 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (529 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (142 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (589 aa)
SH2B3SH2B adapter protein 3. (343 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1566 aa)
NF2Merlin isoform X1. (598 aa)
ENSTSYP00000019212annotation not available (259 aa)
IL12RB1Interleukin-12 receptor subunit beta-1. (644 aa)
ELP2Elongator complex protein 2 isoform X1. (884 aa)
ENSTSYP00000023666annotation not available (397 aa)
ENSTSYP00000024219annotation not available (592 aa)
IL24Interleukin-24. (199 aa)
ENSTSYP00000026316annotation not available (161 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (305 aa)
PIGUPhosphatidylinositol glycan anchor biosynthesis class U protein isoform X1. (435 aa)
GH1Somatotropin. (214 aa)
ENSTSYP00000029747annotation not available (119 aa)
OCIAD2OCIA domain-containing protein 2. (152 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
IL6Interleukin-6. (209 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2339 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
TYK2Tyrosine-protein kinase. (869 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
IL9Interleukin-9. (144 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
CDK5Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
AGAP2LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (784 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
Server load: low (28%) [HD]