node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAX | TP53 | ENSTSYP00000032626 | ENSTSYP00000023752 | Apoptosis regulator BAX isoform X1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.925 |
CDC73 | MYC | ENSTSYP00000028323 | ENSTSYP00000030736 | Parafibromin. | Myc proto-oncogene protein. | 0.400 |
DAB2IP | NF1 | ENSTSYP00000028943 | ENSTSYP00000008701 | Disabled homolog 2-interacting protein. | Neurofibromin isoform X2. | 0.680 |
MED25 | MED31 | ENSTSYP00000017465 | ENSTSYP00000029467 | Mediator of RNA polymerase II transcription subunit 25. | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.980 |
MED31 | MED25 | ENSTSYP00000029467 | ENSTSYP00000017465 | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Mediator of RNA polymerase II transcription subunit 25. | 0.980 |
MYC | CDC73 | ENSTSYP00000030736 | ENSTSYP00000028323 | Myc proto-oncogene protein. | Parafibromin. | 0.400 |
MYC | PARP10 | ENSTSYP00000030736 | ENSTSYP00000020106 | Myc proto-oncogene protein. | Poly [ADP-ribose] polymerase. | 0.700 |
MYC | TP53 | ENSTSYP00000030736 | ENSTSYP00000023752 | Myc proto-oncogene protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.657 |
NF1 | DAB2IP | ENSTSYP00000008701 | ENSTSYP00000028943 | Neurofibromin isoform X2. | Disabled homolog 2-interacting protein. | 0.680 |
NF1 | TP53 | ENSTSYP00000008701 | ENSTSYP00000023752 | Neurofibromin isoform X2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.572 |
NUPR1 | TP53 | ENSTSYP00000007341 | ENSTSYP00000023752 | Nuclear protein 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.435 |
NUPR1 | TP53INP1 | ENSTSYP00000007341 | ENSTSYP00000001725 | Nuclear protein 1. | Tumor protein p53-inducible nuclear protein 1 isoform X1. | 0.444 |
PARP10 | MYC | ENSTSYP00000020106 | ENSTSYP00000030736 | Poly [ADP-ribose] polymerase. | Myc proto-oncogene protein. | 0.700 |
TP53 | BAX | ENSTSYP00000023752 | ENSTSYP00000032626 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Apoptosis regulator BAX isoform X1. | 0.925 |
TP53 | MYC | ENSTSYP00000023752 | ENSTSYP00000030736 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Myc proto-oncogene protein. | 0.657 |
TP53 | NF1 | ENSTSYP00000023752 | ENSTSYP00000008701 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Neurofibromin isoform X2. | 0.572 |
TP53 | NUPR1 | ENSTSYP00000023752 | ENSTSYP00000007341 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Nuclear protein 1. | 0.435 |
TP53 | TP53INP1 | ENSTSYP00000023752 | ENSTSYP00000001725 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Tumor protein p53-inducible nuclear protein 1 isoform X1. | 0.839 |
TP53 | TRIM32 | ENSTSYP00000023752 | ENSTSYP00000005896 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | E3 ubiquitin-protein ligase TRIM32. | 0.430 |
TP53INP1 | NUPR1 | ENSTSYP00000001725 | ENSTSYP00000007341 | Tumor protein p53-inducible nuclear protein 1 isoform X1. | Nuclear protein 1. | 0.444 |