STRINGSTRING
NPPC NPPC PTGS2 PTGS2 HBEGF HBEGF EDN1 EDN1 CTNNB1 CTNNB1 IGFBP3 IGFBP3 FGFR2 FGFR2 NF1 NF1 PTGIR PTGIR AIF1 AIF1 ENSTSYP00000001543 ENSTSYP00000001543 MMP9 MMP9 TGFBR2 TGFBR2 IRAK4 IRAK4 IGF1R IGF1R CCDC142 CCDC142 THBS1 THBS1 VIP VIP TAFA5 TAFA5 PIK3CA PIK3CA EREG EREG NR4A3 NR4A3 IL10 IL10 GJA1 GJA1 NOX1 NOX1 LOC103263247 LOC103263247 WISP1 WISP1 CALCRL CALCRL ITGA2 ITGA2 DNMT1 DNMT1 IL18 IL18 IGFBP5 IGFBP5 BMP2 BMP2 ALOX12 ALOX12 PDCD4 PDCD4 SRC SRC TERT TERT MEF2C MEF2C IL6 IL6 PTEN PTEN PRKDC PRKDC IRAK1 IRAK1 AKT1 AKT1 TGFB1 TGFB1 DBH DBH TGFB3 TGFB3 PDGFB PDGFB IGF1 IGF1 PDGFRB PDGFRB NDRG2 NDRG2 CDKN1B CDKN1B TNFAIP3 TNFAIP3 CYBA CYBA ZNF143 ZNF143 NDRG4 NDRG4 TACR1 TACR1 APLN APLN TCF7L2 TCF7L2 TNF TNF CDKN1A CDKN1A SF1 SF1 PHB PHB RBM10 RBM10 HMOX1 HMOX1 GNA12 GNA12 BMP4 BMP4 MNAT1 MNAT1 NOS3 NOS3 GNA13 GNA13 MEF2D MEF2D CNN1 CNN1 VIPR2 VIPR2 XRCC6 XRCC6 ENSTSYP00000024356 ENSTSYP00000024356 BMPR2 BMPR2 ENSTSYP00000023933 ENSTSYP00000023933 PPARD PPARD LOC103260814 LOC103260814 FOXJ2 FOXJ2 LOC103269106 LOC103269106 FGF9 FGF9 ERN1 ERN1 MFN2 MFN2 EFEMP2 EFEMP2 BMPR1A BMPR1A SERPINF2 SERPINF2 RPS6KB1 RPS6KB1 ID2 ID2 LOC103267910 LOC103267910 ADIPOQ ADIPOQ PPARGC1A PPARGC1A CX3CL1 CX3CL1 CTNNBIP1 CTNNBIP1 FRS2 FRS2 APOD APOD XBP1 XBP1 MAP3K5 MAP3K5 IL12A IL12A ADAMTS1 ADAMTS1 PRKG1 PRKG1 MMP2 MMP2 IFNG IFNG SOD2 SOD2 FOXP1 FOXP1 IL6R IL6R SMPD3 SMPD3 LOC103250564 LOC103250564 LDLRAP1 LDLRAP1 ENSTSYP00000016116 ENSTSYP00000016116 MYOCD MYOCD XRCC5 XRCC5 NPR3 NPR3 LOC103250516 LOC103250516 NOTCH3 NOTCH3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPPCC-type natriuretic peptide. (129 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
EDN1Endothelin-1. (202 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (194 aa)
FGFR2Fibroblast growth factor receptor 2 isoform X1. (615 aa)
NF1Neurofibromin isoform X2. (2839 aa)
PTGIRProstacyclin receptor. (171 aa)
AIF1Allograft inflammatory factor 1. (161 aa)
ENSTSYP00000001543annotation not available (134 aa)
MMP9Matrix metalloproteinase-9. (710 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (558 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
CCDC142Coiled-coil domain-containing protein 142. (684 aa)
THBS1Thrombospondin-1. (1178 aa)
VIPVIP peptides isoform X1. (170 aa)
TAFA5Protein FAM19A5 isoform X2. (130 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EREGProepiregulin. (167 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (642 aa)
IL10Interleukin-10. (178 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (376 aa)
NOX1NADPH oxidase 1 isoform X1. (564 aa)
LOC103263247Arachidonate 12-lipoxygenase, 12S-type-like. (669 aa)
WISP1WNT1-inducible-signaling pathway protein 1. (367 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
ITGA2LOW QUALITY PROTEIN: integrin alpha-2; Belongs to the integrin alpha chain family. (1175 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1375 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
PDCD4Programmed cell death protein 4. (469 aa)
SRCTyrosine-protein kinase. (542 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1078 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
IL6Interleukin-6. (209 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (3073 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (618 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
DBHDopamine beta-hydroxylase. (620 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
NDRG2Protein NDRG2 isoform X1. (371 aa)
CDKN1BLOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1B. (197 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (783 aa)
CYBACytochrome b-245 light chain. (176 aa)
ZNF143Zinc finger protein 143 isoform X2. (638 aa)
NDRG4LOW QUALITY PROTEIN: protein NDRG4. (386 aa)
TACR1substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
APLNApelin. (77 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (565 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
SF1Splicing factor 1. (372 aa)
PHBProhibitin. (272 aa)
RBM10RNA-binding protein 10 isoform X1. (995 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (304 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (409 aa)
MNAT1CDK-activating kinase assembly factor MAT1. (169 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
MEF2DLOW QUALITY PROTEIN: myocyte-specific enhancer factor 2D. (511 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (247 aa)
VIPR2Vasoactive intestinal polypeptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (474 aa)
XRCC6X-ray repair cross-complementing protein 6 isoform X1. (610 aa)
ENSTSYP00000024356annotation not available (326 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
ENSTSYP00000023933annotation not available (330 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
LOC103260814LOW QUALITY PROTEIN: protein NDRG2-like. (341 aa)
FOXJ2Forkhead box protein J2. (568 aa)
LOC103269106cGMP-dependent protein kinase 1-like. (187 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (949 aa)
MFN2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
EFEMP2EGF-containing fibulin-like extracellular matrix protein 2. (443 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SERPINF2Alpha-2-antiplasmin; Belongs to the serpin family. (368 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ID2DNA-binding protein inhibitor ID-2. (129 aa)
LOC103267910Fibroblast growth factor receptor 2-like. (208 aa)
ADIPOQAdiponectin isoform X1. (244 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2. (798 aa)
CX3CL1Fractalkine isoform X2. (402 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
APODApolipoprotein D. (198 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (376 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1329 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1. (784 aa)
PRKG1cGMP-dependent protein kinase 1; Belongs to the protein kinase superfamily. (406 aa)
MMP272 kDa type IV collagenase. (662 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (221 aa)
FOXP1Forkhead box protein P1 isoform X1. (694 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
LOC103250564Integrin beta; Belongs to the integrin beta chain family. (418 aa)
LDLRAP1Low density lipoprotein receptor adapter protein 1. (280 aa)
ENSTSYP00000016116annotation not available (333 aa)
MYOCDMyocardin isoform X1. (792 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
NPR3Atrial natriuretic peptide receptor 3. (319 aa)
LOC103250516Discoidin domain-containing receptor 2-like. (168 aa)
NOTCH3Neurogenic locus notch homolog protein 3. (2169 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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