(65 nodes) Presynaptic active zone network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC17A7	Vesicular glutamate transporter 1. (469 aa)
	CTNND1	Catenin delta-1 isoform X1. (983 aa)
	RAB3A	Ras-related protein Rab-3A. (201 aa)
	ERC1	ELKS/Rab6-interacting/CAST family member 1. (756 aa)
	RIMS3	Regulating synaptic membrane exocytosis protein 3. (308 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (406 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains protein 2. (1158 aa)
	CPLX3	Complexin-3. (158 aa)
	ADORA2A	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
	SLC32A1	Vesicular inhibitory amino acid transporter. (525 aa)
	SYT11	Synaptotagmin-11 isoform X1. (431 aa)
	SYN1	Synapsin-1. (616 aa)
	PNISR	Arginine/serine-rich protein PNISR isoform X1. (803 aa)
	ENSTSYP00000027860	annotation not available (375 aa)
	NRG1	Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
	P2RY4	P2Y purinoceptor 4; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	STX3	Syntaxin-3 isoform X3; Belongs to the syntaxin family. (294 aa)
	NECTIN1	Nectin-1. (509 aa)
	BRSK1	LOW QUALITY PROTEIN: serine/threonine-protein kinase BRSK1. (737 aa)
	UNC13B	Protein unc-13 homolog B isoform X4. (4153 aa)
	GUCY1B3	Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (623 aa)
	APP	Amyloid beta A4 protein isoform X1. (765 aa)
	SV2A	Synaptic vesicle glycoprotein 2A. (742 aa)
	ENSTSYP00000022290	annotation not available (424 aa)
	NRXN1	Neurexin-1 isoform X5. (1229 aa)
	PPFIA4	Liprin-alpha-4 isoform X1. (1185 aa)
	ATP2B1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
	OTOF	Otoferlin isoform X1. (1998 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1140 aa)
	NTNG2	Netrin G2. (384 aa)
	ATP2B2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
	UNC13C	Protein unc-13 homolog C isoform X1. (135 aa)
	STX1B	syntaxin-1B; Belongs to the syntaxin family. (243 aa)
	GAD1	Glutamate decarboxylase 1. (589 aa)
	BSN	Protein bassoon. (3896 aa)
	ARHGAP44	Rho GTPase-activating protein 44 isoform X1. (816 aa)
	CTBP1	C-terminal-binding protein 1 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (420 aa)
	LOC103257309	Regulating synaptic membrane exocytosis protein 2. (461 aa)
	NPTN	Neuroplastin isoform X1. (397 aa)
	NTNG1	netrin-G1. (403 aa)
	CDH10	Cadherin-10 isoform X2; Cadherins are calcium-dependent cell adhesion proteins. (788 aa)
	RIMS1	Regulating synaptic membrane exocytosis protein 1 isoform X17. (1191 aa)
	APBA1	Amyloid beta A4 precursor protein-binding family A member 1. (387 aa)
	LOC103268507	Guanylate cyclase soluble subunit beta-2. (709 aa)
	PPFIBP2	Liprin-beta-2 isoform X2. (875 aa)
	ADCY8	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (931 aa)
	CTNNB1	Catenin beta-1 isoform X1. (783 aa)
	PPFIBP1	Liprin-beta-1 isoform X2. (1009 aa)
	TPRG1L	Tumor protein p63 regulated 1 like. (243 aa)
	RIMS4	Regulating synaptic membrane exocytosis protein 4 isoform X1. (272 aa)
	FZD3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa)
	PPFIA2	Liprin-alpha-2 isoform X5. (722 aa)
	P2RY1	P2Y purinoceptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	STX4	Syntaxin-4 isoform X4; Belongs to the syntaxin family. (298 aa)
	NUFIP1	Nuclear fragile X mental retardation-interacting protein 1. (494 aa)
	C1QBP	LOW QUALITY PROTEIN: complement component 1 Q subcomponent-binding protein, mitochondrial. (279 aa)
	PPFIA3	Liprin-alpha-3. (1201 aa)
	PPFIA1	Liprin-alpha-1 isoform X2. (1114 aa)
	LRFN3	Leucine-rich repeat and fibronectin type-III domain-containing protein 3. (626 aa)
	ZZEF1	Zinc finger ZZ-type and EF-hand domain-containing protein 1. (2966 aa)
	EGFLAM	Pikachurin isoform X2. (1017 aa)
	STX2	Syntaxin-2; Belongs to the syntaxin family. (278 aa)
	CNTNAP1	Contactin-associated protein 1. (1310 aa)
	VPS11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
	CTBP2	C-terminal-binding protein 2 isoform X1. (987 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2A	P2RY1	ENSTSYP00000031738	ENSTSYP00000007388	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	P2Y purinoceptor 1; Belongs to the G-protein coupled receptor 1 family.	0.868
APBA1	APP	ENSTSYP00000011247	ENSTSYP00000022766	Amyloid beta A4 precursor protein-binding family A member 1.	Amyloid beta A4 protein isoform X1.	0.985
APBA1	LOC103257309	ENSTSYP00000011247	ENSTSYP00000013643	Amyloid beta A4 precursor protein-binding family A member 1.	Regulating synaptic membrane exocytosis protein 2.	0.986
APBA1	NRXN1	ENSTSYP00000011247	ENSTSYP00000020991	Amyloid beta A4 precursor protein-binding family A member 1.	Neurexin-1 isoform X5.	0.644
APBA1	PPFIA1	ENSTSYP00000011247	ENSTSYP00000004360	Amyloid beta A4 precursor protein-binding family A member 1.	Liprin-alpha-1 isoform X2.	0.613
APBA1	PPFIA2	ENSTSYP00000011247	ENSTSYP00000007859	Amyloid beta A4 precursor protein-binding family A member 1.	Liprin-alpha-2 isoform X5.	0.613
APBA1	PPFIA3	ENSTSYP00000011247	ENSTSYP00000004592	Amyloid beta A4 precursor protein-binding family A member 1.	Liprin-alpha-3.	0.681
APBA1	PPFIA4	ENSTSYP00000011247	ENSTSYP00000020673	Amyloid beta A4 precursor protein-binding family A member 1.	Liprin-alpha-4 isoform X1.	0.613
APBA1	RAB3A	ENSTSYP00000011247	ENSTSYP00000034540	Amyloid beta A4 precursor protein-binding family A member 1.	Ras-related protein Rab-3A.	0.534
APBA1	RIMS1	ENSTSYP00000011247	ENSTSYP00000011382	Amyloid beta A4 precursor protein-binding family A member 1.	Regulating synaptic membrane exocytosis protein 1 isoform X17.	0.651
APBA1	RIMS3	ENSTSYP00000011247	ENSTSYP00000034253	Amyloid beta A4 precursor protein-binding family A member 1.	Regulating synaptic membrane exocytosis protein 3.	0.676
APBA1	RIMS4	ENSTSYP00000011247	ENSTSYP00000008335	Amyloid beta A4 precursor protein-binding family A member 1.	Regulating synaptic membrane exocytosis protein 4 isoform X1.	0.551
APBA1	STX1B	ENSTSYP00000011247	ENSTSYP00000016809	Amyloid beta A4 precursor protein-binding family A member 1.	syntaxin-1B; Belongs to the syntaxin family.	0.929
APBA1	STX2	ENSTSYP00000011247	ENSTSYP00000002338	Amyloid beta A4 precursor protein-binding family A member 1.	Syntaxin-2; Belongs to the syntaxin family.	0.855
APBA1	STX3	ENSTSYP00000011247	ENSTSYP00000025636	Amyloid beta A4 precursor protein-binding family A member 1.	Syntaxin-3 isoform X3; Belongs to the syntaxin family.	0.855
APBA1	STX4	ENSTSYP00000011247	ENSTSYP00000006164	Amyloid beta A4 precursor protein-binding family A member 1.	Syntaxin-4 isoform X4; Belongs to the syntaxin family.	0.855
APBA1	SYN1	ENSTSYP00000011247	ENSTSYP00000028850	Amyloid beta A4 precursor protein-binding family A member 1.	Synapsin-1.	0.592
APBA1	UNC13B	ENSTSYP00000011247	ENSTSYP00000023530	Amyloid beta A4 precursor protein-binding family A member 1.	Protein unc-13 homolog B isoform X4.	0.627
APBA1	UNC13C	ENSTSYP00000011247	ENSTSYP00000016974	Amyloid beta A4 precursor protein-binding family A member 1.	Protein unc-13 homolog C isoform X1.	0.627
APP	APBA1	ENSTSYP00000022766	ENSTSYP00000011247	Amyloid beta A4 protein isoform X1.	Amyloid beta A4 precursor protein-binding family A member 1.	0.985