STRINGSTRING
IGFBP3 IGFBP3 CTNNB1 CTNNB1 EAF2 EAF2 LIMS2 LIMS2 FSHB FSHB VSTM4 VSTM4 NOTCH2 NOTCH2 IFT172 IFT172 HGF HGF PROK2 PROK2 C6orf89 C6orf89 PURA PURA HMX2 HMX2 DLG1 DLG1 ESRP2 ESRP2 BCL2L1 BCL2L1 SHH SHH SIDT2 SIDT2 IFT74 IFT74 PROK1 PROK1 RETNLB RETNLB DACH1 DACH1 WNT2 WNT2 ACVR2A ACVR2A ESR1 ESR1 IFT80 IFT80 FAP FAP LGR5 LGR5 FERMT1 FERMT1 EREG EREG LOXL2 LOXL2 LGR4 LGR4 KDR KDR IGFBP4 IGFBP4 PTCH1 PTCH1 COL8A1 COL8A1 FSHR FSHR IFT52 IFT52 TRIM24 TRIM24 PROX1 PROX1 IFT57 IFT57 LIPA LIPA ENSTSYP00000001543 ENSTSYP00000001543 FLCN FLCN ITGB1BP1 ITGB1BP1 CALCA CALCA HSF4 HSF4 TGFB1 TGFB1 RPS6KA1 RPS6KA1 IL6 IL6 STK4 STK4 SMO SMO MEF2C MEF2C FABP7 FABP7 MAPK1 MAPK1 CAV1 CAV1 PSEN1 PSEN1 MED1 MED1 EYA1 EYA1 BAX BAX MTSS1 MTSS1 NOTCH1 NOTCH1 IQGAP3 IQGAP3 THAP1 THAP1 PIK3CB PIK3CB IGFBP5 IGFBP5 CCN3 CCN3 TGFBR1 TGFBR1 NOX5 NOX5 ENSTSYP00000015975 ENSTSYP00000015975 FGF7 FGF7 YAP1 YAP1 MKI67 MKI67 AGAP2 AGAP2 SCARB1 SCARB1 COL8A2 COL8A2 FGF1 FGF1 LOC103267910 LOC103267910 ID2 ID2 KLK8 KLK8 FST FST BMPR1A BMPR1A TEK TEK HLX HLX FGF10 FGF10 ENSTSYP00000021729 ENSTSYP00000021729 ENSTSYP00000021856 ENSTSYP00000021856 APOA1 APOA1 TGFA TGFA ERN1 ERN1 BTRC BTRC FGF9 FGF9 CCND1 CCND1 NCSTN NCSTN EHF EHF ZEB1 ZEB1 PPARD PPARD BMPR2 BMPR2 WNT5A WNT5A TBX2 TBX2 SFN SFN KDF1 KDF1 OVOL1 OVOL1 CD34 CD34 TNFSF11 TNFSF11 WDR77 WDR77 TP63 TP63 BMP4 BMP4 ENSTSYP00000026316 ENSTSYP00000026316 ENSTSYP00000026542 ENSTSYP00000026542 STK11 STK11 DRD2 DRD2 SEMA5A SEMA5A SERPINB1 SERPINB1 BAK1 BAK1 TNF TNF SDR16C5 SDR16C5 IRF6 IRF6 CDKN1B CDKN1B MTA3 MTA3 CD109 CD109 CYP7B1 CYP7B1 SAV1 SAV1 EGF EGF NF1 NF1 EPHA2 EPHA2 AR AR AREG AREG WNT16 WNT16 BMPER BMPER RASGRF1 RASGRF1 SERPINF1 SERPINF1 CAV2 CAV2 A4GNT A4GNT FGFR2 FGFR2 RB1 RB1 FGL1 FGL1 XBP1 XBP1 BTBD10 BTBD10 B4GALT1 B4GALT1 STAT6 STAT6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGFBP3Insulin-like growth factor-binding protein 3. (194 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
EAF2ELL-associated factor 2 isoform X4. (264 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein 2. (229 aa)
FSHBFollitropin subunit beta. (129 aa)
VSTM4V-set and transmembrane domain-containing protein 4. (221 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2211 aa)
IFT172Intraflagellar transport protein 172 homolog. (1749 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
PROK2Prokineticin-2. (109 aa)
C6orf89Bombesin receptor-activated protein C6orf89 homolog isoform X1. (354 aa)
PURATranscriptional activator protein Pur-alpha. (261 aa)
HMX2H6 family homeobox 2. (248 aa)
DLG1Disks large homolog 1 isoform X5; Belongs to the MAGUK family. (460 aa)
ESRP2Epithelial splicing regulatory protein 2. (726 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
SHHSonic hedgehog signaling molecule. (368 aa)
SIDT2SID1 transmembrane family member 2 isoform X2. (843 aa)
IFT74Intraflagellar transport protein 74 homolog. (600 aa)
PROK1Prokineticin-1. (105 aa)
RETNLBResistin-like beta. (113 aa)
DACH1LOW QUALITY PROTEIN: dachshund homolog 1. (693 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
IFT80Intraflagellar transport protein 80 homolog. (777 aa)
FAPProlyl endopeptidase FAP isoform X1; Belongs to the peptidase S9B family. (760 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5. (907 aa)
FERMT1Fermitin family homolog 1. (677 aa)
EREGProepiregulin. (167 aa)
LOXL2Lysyl oxidase homolog 2 isoform X1. (774 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (946 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
PTCH1Protein patched homolog 1. (1318 aa)
COL8A1Collagen alpha-1(VIII) chain. (745 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (620 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (437 aa)
TRIM24Transcription intermediary factor 1-alpha. (1042 aa)
PROX1Prospero homeobox protein 1. (737 aa)
IFT57Intraflagellar transport protein 57 homolog isoform X1. (429 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (402 aa)
ENSTSYP00000001543annotation not available (134 aa)
FLCNFolliculin. (579 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (200 aa)
CALCACalcitonin isoform X2. (142 aa)
HSF4Heat shock factor protein 4 isoform X1. (491 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
IL6Interleukin-6. (209 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
FABP7Fatty acid-binding protein, brain; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
MTSS1Metastasis suppressor protein 1. (709 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2339 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3. (1632 aa)
THAP1THAP domain-containing protein 1. (213 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
CCN3Protein NOV homolog. (255 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (487 aa)
NOX5NADPH oxidase 5. (716 aa)
ENSTSYP00000015975annotation not available (174 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (326 aa)
MKI67LOW QUALITY PROTEIN: proliferation marker protein Ki-67. (3251 aa)
AGAP2LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (784 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (467 aa)
COL8A2Collagen alpha-2(VIII) chain isoform X1. (700 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOC103267910Fibroblast growth factor receptor 2-like. (208 aa)
ID2DNA-binding protein inhibitor ID-2. (129 aa)
KLK8Kallikrein-8 isoform X1; Belongs to the peptidase S1 family. (283 aa)
FSTFollistatin. (349 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
HLXH2.0-like homeobox protein. (488 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ENSTSYP00000021729annotation not available (109 aa)
ENSTSYP00000021856annotation not available (88 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (266 aa)
TGFATransforming growth factor alpha. (164 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (949 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (589 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
NCSTNNicastrin isoform X1. (708 aa)
EHFETS homologous factor isoform X1. (302 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (1105 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TBX2T-box transcription factor TBX2. (458 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
OVOL1Putative transcription factor Ovo-like 1. (258 aa)
CD34Hematopoietic progenitor cell antigen CD34. (383 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (250 aa)
WDR77Methylosome protein 50 isoform X2. (342 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (690 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (409 aa)
ENSTSYP00000026316annotation not available (161 aa)
ENSTSYP00000026542annotation not available (416 aa)
STK11Serine/threonine-protein kinase STK11. (364 aa)
DRD2D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SEMA5Asemaphorin-5A. (335 aa)
SERPINB1Leukocyte elastase inhibitor; Belongs to the serpin family. (187 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
SDR16C5Epidermal retinol dehydrogenase 2 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
IRF6Interferon regulatory factor 6 isoform X1. (467 aa)
CDKN1BLOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1B. (197 aa)
MTA3Metastasis-associated protein MTA3 isoform X1. (533 aa)
CD109CD109 antigen. (1470 aa)
CYP7B125-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (506 aa)
SAV1Protein salvador homolog 1 isoform X1. (384 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
NF1Neurofibromin isoform X2. (2839 aa)
EPHA2LOW QUALITY PROTEIN: ephrin type-A receptor 2. (917 aa)
ARAndrogen receptor. (887 aa)
AREGAmphiregulin isoform X1. (270 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
BMPERBMP-binding endothelial regulator protein. (685 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1 isoform X1. (1257 aa)
SERPINF1Pigment epithelium-derived factor isoform X1; Belongs to the serpin family. (418 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
A4GNTalpha-1,4-N-acetylglucosaminyltransferase. (341 aa)
FGFR2Fibroblast growth factor receptor 2 isoform X1. (615 aa)
RB1Retinoblastoma-associated protein. (929 aa)
FGL1Fibrinogen-like protein 1 isoform X1. (312 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (376 aa)
BTBD10BTB/POZ domain-containing protein 10 isoform X1. (484 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.