STRINGSTRING
CD40 CD40 EFNA1 EFNA1 LOC103250673 LOC103250673 IL18 IL18 CSF1R CSF1R PTK2B PTK2B CD81 CD81 ENSTSYP00000033980 ENSTSYP00000033980 ENSTSYP00000033832 ENSTSYP00000033832 CNTF CNTF CRLF1 CRLF1 SRC SRC DOK7 DOK7 SRCIN1 SRCIN1 IL6 IL6 EPO EPO TGFB1 TGFB1 DVL2 DVL2 EPGN EPGN ITGA5 ITGA5 IL20 IL20 CSPG4 CSPG4 MLST8 MLST8 HTR2A HTR2A PDGFB PDGFB IGF1 IGF1 GH1 GH1 IL2 IL2 ALKAL2 ALKAL2 ANGPT4 ANGPT4 CLCF1 CLCF1 GHRL GHRL HPX HPX NRG1 NRG1 TNFRSF1A TNFRSF1A EHD4 EHD4 WNT3A WNT3A NEDD9 NEDD9 FBXW9 FBXW9 IL24 IL24 CSF3 CSF3 ACVR1 ACVR1 IL34 IL34 FGFR3 FGFR3 LIF LIF IGF2 IGF2 RICTOR RICTOR TP53 TP53 CTF1 CTF1 KITLG KITLG FBXW7 FBXW7 GRM5 GRM5 TGFA TGFA FGF10 FGF10 TNFRSF18 TNFRSF18 LTK LTK ALKAL1 ALKAL1 PECAM1 PECAM1 OSM OSM ENSTSYP00000020437 ENSTSYP00000020437 CD44 CD44 VEGFA VEGFA LRP8 LRP8 NCF1 NCF1 HSF1 HSF1 ADIPOQ ADIPOQ ENSTSYP00000017967 ENSTSYP00000017967 EPHA4 EPHA4 SYK SYK NOD2 NOD2 GFRA1 GFRA1 IL6ST IL6ST MIF MIF SEMA4D SEMA4D CD36 CD36 IL23A IL23A GAS6 GAS6 LOC103250564 LOC103250564 TNK2 TNK2 PTK6 PTK6 ADNP ADNP FGF7 FGF7 ENSTSYP00000015664 ENSTSYP00000015664 PLCG2 PLCG2 TREM2 TREM2 ENSTSYP00000014591 ENSTSYP00000014591 CD74 CD74 DLG3 DLG3 FYN FYN CNTN1 CNTN1 STAP1 STAP1 RELN RELN PARP9 PARP9 GDNF GDNF TDGF1 TDGF1 HGF HGF DLG4 DLG4 HCLS1 HCLS1 MTOR MTOR IL31RA IL31RA ADRA1A ADRA1A PAK2 PAK2 IL15 IL15 HBEGF HBEGF LRRK1 LRRK1 TSLP TSLP FLT3 FLT3 ANGPT1 ANGPT1 CASS4 CASS4 LRP4 LRP4 IL5 IL5 JAK2 JAK2 CLEC6A CLEC6A GPRC5B GPRC5B AREG AREG OSBP OSBP ALK ALK IL4 IL4 HDAC2 HDAC2 EGF EGF ADAM17 ADAM17 NTF3 NTF3 LOC103259375 LOC103259375 CSF2 CSF2 ISL1 ISL1 SH2D1B SH2D1B ARHGEF2 ARHGEF2 ERBB4 ERBB4 IL23R IL23R ABI1 ABI1 RIPK2 RIPK2 EGFR EGFR CD80 CD80 PARP14 PARP14 EREG EREG PIBF1 PIBF1 AGT AGT ARL2BP ARL2BP TNFSF18 TNFSF18 KIT KIT PLPP3 PLPP3 PTPRJ PTPRJ GATA1 GATA1 BMP6 BMP6 YES1 YES1 AFAP1L2 AFAP1L2 PTPN11 PTPN11 DGKQ DGKQ ERCC6 ERCC6 IL21 IL21 ENPP2 ENPP2 ABL1 ABL1 NRP1 NRP1 IFNG IFNG BTC BTC PTPN1 PTPN1 IL12A IL12A CD3E CD3E PTPRC PTPRC LYN LYN IL6R IL6R EFNA5 EFNA5 THBS4 THBS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD40Tumor necrosis factor receptor superfamily member 5 isoform X2. (277 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
LOC103250673HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (278 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (965 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CD81Tetraspanin. (244 aa)
ENSTSYP00000033980annotation not available (70 aa)
ENSTSYP00000033832annotation not available (140 aa)
CNTFCiliary neurotrophic factor. (200 aa)
CRLF1Cytokine receptor-like factor 1. (383 aa)
SRCTyrosine-protein kinase. (542 aa)
DOK7LOW QUALITY PROTEIN: protein Dok-7. (219 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1088 aa)
IL6Interleukin-6. (209 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (736 aa)
EPGNEpigen isoform X1. (153 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1053 aa)
IL20Interleukin-20 isoform X1. (175 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2323 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X2. (326 aa)
HTR2A5-hydroxytryptamine receptor 2A isoform X1. (471 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
GH1Somatotropin. (214 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
ALKAL2ALK and LTK ligand 2. (162 aa)
ANGPT4Angiopoietin-4. (488 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (260 aa)
GHRLAppetite-regulating hormone. (117 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (183 aa)
EHD4EH domain-containing protein 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NEDD9Enhancer of filamentation 1. (834 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
IL24Interleukin-24. (199 aa)
CSF3Granulocyte colony-stimulating factor isoform X2. (204 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
IL34Interleukin-34 isoform X1. (240 aa)
FGFR3Fibroblast growth factor receptor. (745 aa)
LIFLeukemia inhibitory factor. (202 aa)
IGF2Insulin like growth factor 2. (147 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1699 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
CTF1Cardiotrophin-1. (204 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (708 aa)
GRM5Metabotropic glutamate receptor 5. (867 aa)
TGFATransforming growth factor alpha. (164 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TNFRSF18Tumor necrosis factor receptor superfamily member 18. (206 aa)
LTKTyrosine-protein kinase receptor. (780 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
PECAM1Platelet endothelial cell adhesion molecule. (737 aa)
OSMoncostatin-M. (251 aa)
ENSTSYP00000020437annotation not available (273 aa)
CD44CD44 antigen. (219 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
LRP8Low-density lipoprotein receptor-related protein 8 isoform X1. (936 aa)
NCF1LOW QUALITY PROTEIN: neutrophil cytosol factor 1. (232 aa)
HSF1Heat shock factor protein 1 isoform X2. (523 aa)
ADIPOQAdiponectin isoform X1. (244 aa)
ENSTSYP00000017967annotation not available (148 aa)
EPHA4Ephrin type-A receptor 4 isoform X2. (949 aa)
SYKTyrosine-protein kinase. (634 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1040 aa)
GFRA1GDNF family receptor alpha-1-like. (323 aa)
IL6STInterleukin-6 receptor subunit beta. (917 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (733 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
GAS6Growth arrest-specific protein 6. (440 aa)
LOC103250564Integrin beta; Belongs to the integrin beta chain family. (418 aa)
TNK2Activated CDC42 kinase 1 isoform X5; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1063 aa)
PTK6Tyrosine-protein kinase. (450 aa)
ADNPActivity-dependent neuroprotector homeobox protein. (1101 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ENSTSYP00000015664annotation not available (68 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
ENSTSYP00000014591annotation not available (71 aa)
CD74HLA class II histocompatibility antigen gamma chain. (166 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (839 aa)
FYNTyrosine-protein kinase. (537 aa)
CNTN1Contactin-1 isoform X1. (1017 aa)
STAP1Signal-transducing adaptor protein 1. (292 aa)
RELNReelin. (3443 aa)
PARP9Poly [ADP-ribose] polymerase 9 isoform X1. (856 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X3. (211 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
DLG4Disks large homolog 4 isoform X1; Belongs to the MAGUK family. (765 aa)
HCLS1Hematopoietic lineage cell-specific protein. (469 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IL31RALOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha. (744 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (2014 aa)
TSLPThymic stromal lymphopoietin. (291 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (980 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
CASS4Cas scaffolding protein family member 4. (783 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1912 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
CLEC6AC-type lectin domain family 6 member A-like. (209 aa)
GPRC5BG-protein coupled receptor family C group 5 member B isoform X1. (404 aa)
AREGAmphiregulin isoform X1. (270 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (807 aa)
ALKTyrosine-protein kinase receptor. (1397 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (142 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (824 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (264 aa)
LOC103259375High affinity immunoglobulin gamma Fc receptor I-like isoform X1. (371 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
ISL1Insulin gene enhancer protein ISL-1 isoform X1. (353 aa)
SH2D1BSH2 domain-containing protein 1B. (132 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1013 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
IL23RInterleukin-23 receptor. (628 aa)
ABI1Abl interactor 1 isoform X1. (498 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2 isoform X1. (539 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
CD80T-lymphocyte activation antigen CD80. (232 aa)
PARP14Poly [ADP-ribose] polymerase. (1801 aa)
EREGProepiregulin. (167 aa)
PIBF1Progesterone-induced-blocking factor 1. (756 aa)
AGTAngiotensinogen; Belongs to the serpin family. (487 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein. (163 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (200 aa)
KITMast/stem cell growth factor receptor Kit; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta. (1260 aa)
GATA1Erythroid transcription factor. (413 aa)
BMP6Bone morphogenetic protein 6. (513 aa)
YES1Tyrosine-protein kinase. (546 aa)
AFAP1L2Actin filament-associated protein 1-like 2. (820 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (532 aa)
DGKQDiacylglycerol kinase. (941 aa)
ERCC6DNA excision repair protein ERCC-6. (1481 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X2. (915 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (927 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
BTCProbetacellulin. (178 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (434 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (178 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (601 aa)
LYNTyrosine-protein kinase. (512 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (228 aa)
THBS4Thrombospondin-4. (865 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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