(48 nodes) Defense response to Gram-negative bacterium network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CALCA	Calcitonin isoform X2. (142 aa)
	BPI	Bactericidal permeability-increasing protein. (508 aa)
	ENSTSYP00000008894	annotation not available (139 aa)
	DEFB114	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
	IL17A	interleukin-17A. (152 aa)
	LTF	Lactotransferrin isoform X1; Belongs to the transferrin family. (710 aa)
	TSLP	Thymic stromal lymphopoietin. (291 aa)
	BPIFC	BPI fold-containing family C protein. (507 aa)
	DEFB119	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
	DEFB1	Beta-defensin 1. (67 aa)
	ENSTSYP00000014579	annotation not available (98 aa)
	SLC11A1	Natural resistance-associated macrophage protein 1 isoform X1. (522 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	CHGA	chromogranin-A isoform X4. (303 aa)
	IL23A	Interleukin-23 subunit alpha. (189 aa)
	ADGRB1	Brain-specific angiogenesis inhibitor 1. (1462 aa)
	ENSTSYP00000017967	annotation not available (148 aa)
	H2BC11	Histone H2B; Belongs to the histone H2B family. (126 aa)
	ENSTSYP00000020578	annotation not available (98 aa)
	LYPD8	ly6/PLAUR domain-containing protein 8. (228 aa)
	DEFB136	Beta-defensin 136. (78 aa)
	TAC1	Tachykinin precursor 1. (130 aa)
	SERPINE1	Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
	ENSTSYP00000028986	annotation not available (137 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	ENSTSYP00000032235	annotation not available (79 aa)
	DMBT1	Deleted in malignant brain tumors 1 protein. (1855 aa)
	UMOD	Uromodulin. (687 aa)
	DROSHA	Ribonuclease 3. (232 aa)
	TUSC2	Tumor suppressor candidate 2 isoform X2. (110 aa)
	AQP1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (179 aa)
	RPL30	60S ribosomal protein L30 isoform X1. (115 aa)
	CST11	Cystatin-11. (138 aa)
	IL6R	Interleukin-6 receptor subunit alpha. (465 aa)
	SELP	P-selectin. (830 aa)
	MR1	Major histocompatibility complex class I-related gene protein isoform X1; Belongs to the MHC class I family. (341 aa)
	TREM1	Triggering receptor expressed on myeloid cells 1. (225 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
	CTSG	Cathepsin G-like; Belongs to the peptidase S1 family. (256 aa)
	LBP	Lipopolysaccharide-binding protein. (481 aa)
	TLR4	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (840 aa)
	LOC103266290	Protein S100-A7-like. (99 aa)
	GSDMD	gasdermin-D. (529 aa)
	CD160	CD160 antigen isoform X2. (181 aa)
	ROMO1	Reactive oxygen species modulator 1. (79 aa)
	ENSTSYP00000005302	annotation not available (101 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	IL23R	Interleukin-23 receptor. (628 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BPI	CTSG	ENSTSYP00000007769	ENSTSYP00000002339	Bactericidal permeability-increasing protein.	Cathepsin G-like; Belongs to the peptidase S1 family.	0.714
BPI	LBP	ENSTSYP00000007769	ENSTSYP00000003079	Bactericidal permeability-increasing protein.	Lipopolysaccharide-binding protein.	0.566
BPI	LTF	ENSTSYP00000007769	ENSTSYP00000010401	Bactericidal permeability-increasing protein.	Lactotransferrin isoform X1; Belongs to the transferrin family.	0.664
BPI	TLR4	ENSTSYP00000007769	ENSTSYP00000003281	Bactericidal permeability-increasing protein.	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family.	0.599
BPIFC	TLR4	ENSTSYP00000011304	ENSTSYP00000003281	BPI fold-containing family C protein.	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family.	0.505
CALCA	ENSTSYP00000028986	ENSTSYP00000030293	ENSTSYP00000028986	Calcitonin isoform X2.	annotation not available	0.905
CALCA	TAC1	ENSTSYP00000030293	ENSTSYP00000026025	Calcitonin isoform X2.	Tachykinin precursor 1.	0.543
CTSG	BPI	ENSTSYP00000002339	ENSTSYP00000007769	Cathepsin G-like; Belongs to the peptidase S1 family.	Bactericidal permeability-increasing protein.	0.714
CTSG	ENSTSYP00000017967	ENSTSYP00000002339	ENSTSYP00000017967	Cathepsin G-like; Belongs to the peptidase S1 family.	annotation not available	0.502
CTSG	F2	ENSTSYP00000002339	ENSTSYP00000006008	Cathepsin G-like; Belongs to the peptidase S1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.564
CTSG	GSDMD	ENSTSYP00000002339	ENSTSYP00000004392	Cathepsin G-like; Belongs to the peptidase S1 family.	gasdermin-D.	0.559
CTSG	LBP	ENSTSYP00000002339	ENSTSYP00000003079	Cathepsin G-like; Belongs to the peptidase S1 family.	Lipopolysaccharide-binding protein.	0.461
CTSG	LTF	ENSTSYP00000002339	ENSTSYP00000010401	Cathepsin G-like; Belongs to the peptidase S1 family.	Lactotransferrin isoform X1; Belongs to the transferrin family.	0.675
CTSG	SERPINE1	ENSTSYP00000002339	ENSTSYP00000028741	Cathepsin G-like; Belongs to the peptidase S1 family.	Plasminogen activator inhibitor 1; Belongs to the serpin family.	0.463
DEFB1	DEFB114	ENSTSYP00000012491	ENSTSYP00000009372	Beta-defensin 1.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.429
DEFB1	DEFB119	ENSTSYP00000012491	ENSTSYP00000011676	Beta-defensin 1.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.814
DEFB1	DEFB136	ENSTSYP00000012491	ENSTSYP00000022472	Beta-defensin 1.	Beta-defensin 136.	0.649
DEFB114	DEFB1	ENSTSYP00000009372	ENSTSYP00000012491	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin 1.	0.429
DEFB114	DEFB136	ENSTSYP00000009372	ENSTSYP00000022472	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin 136.	0.519
DEFB119	DEFB1	ENSTSYP00000011676	ENSTSYP00000012491	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin 1.	0.814