STRINGSTRING
C5AR1 C5AR1 IL6R IL6R MR1 MR1 IL12A IL12A NOD1 NOD1 PLA2G2A PLA2G2A P2RX7 P2RX7 CTSG CTSG PGLYRP4 PGLYRP4 LBP LBP GSDMD GSDMD PGLYRP3 PGLYRP3 ROMO1 ROMO1 RIPK2 RIPK2 KLRK1 KLRK1 ENSTSYP00000006680 ENSTSYP00000006680 SEH1L SEH1L CARD9 CARD9 MYD88 MYD88 PYCARD PYCARD IL1B IL1B GBP7 GBP7 ADAM17 ADAM17 CUNH10orf99 CUNH10orf99 EPHA2 EPHA2 ENSTSYP00000008894 ENSTSYP00000008894 MBL2 MBL2 DEFB114 DEFB114 ZG16 ZG16 IL17A IL17A LTF LTF IL7R IL7R STAB2 STAB2 LYZ LYZ DEFB119 DEFB119 CRP CRP TNFSF8 TNFSF8 DEFB1 DEFB1 GBP4 GBP4 FAU FAU PGLYRP1 PGLYRP1 IL27RA IL27RA PGLYRP2 PGLYRP2 ENSTSYP00000013827 ENSTSYP00000013827 HAVCR2 HAVCR2 FGR FGR CHGA CHGA RPL39 RPL39 CD36 CD36 ACP5 ACP5 NOD2 NOD2 TBK1 TBK1 H2BC11 H2BC11 ENSTSYP00000021724 ENSTSYP00000021724 DEFB136 DEFB136 ENSTSYP00000022646 ENSTSYP00000022646 TIRAP TIRAP LOC103259954 LOC103259954 PLA2G1B PLA2G1B TAC1 TAC1 TNF TNF ENSTSYP00000028986 ENSTSYP00000028986 LYG2 LYG2 CALCA CALCA LTA LTA PPP1R11 PPP1R11 ENSTSYP00000032235 ENSTSYP00000032235 NLRP3 NLRP3 DMBT1 DMBT1 DROSHA DROSHA ENSTSYP00000034010 ENSTSYP00000034010 ENSTSYP00000034265 ENSTSYP00000034265 IL18 IL18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
MR1Major histocompatibility complex class I-related gene protein isoform X1; Belongs to the MHC class I family. (341 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
PLA2G2APhospholipase A(2). (144 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CTSGCathepsin G-like; Belongs to the peptidase S1 family. (256 aa)
PGLYRP4Peptidoglycan recognition protein 4. (373 aa)
LBPLipopolysaccharide-binding protein. (481 aa)
GSDMDgasdermin-D. (529 aa)
PGLYRP3Peptidoglycan recognition protein 3 isoform X1. (341 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2 isoform X1. (539 aa)
KLRK1NKG2-D type II integral membrane protein-like. (173 aa)
ENSTSYP00000006680annotation not available (255 aa)
SEH1LNucleoporin SEH1 isoform X2; Belongs to the WD repeat SEC13 family. (360 aa)
CARD9Caspase recruitment domain-containing protein 9. (541 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
GBP7Guanylate-binding protein 7-like isoform X1. (614 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (824 aa)
CUNH10orf99Secreted protein C10orf99 homolog. (78 aa)
EPHA2LOW QUALITY PROTEIN: ephrin type-A receptor 2. (917 aa)
ENSTSYP00000008894annotation not available (139 aa)
MBL2Mannose-binding protein C. (247 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
ZG16Zymogen granule membrane protein 16. (167 aa)
IL17Ainterleukin-17A. (152 aa)
LTFLactotransferrin isoform X1; Belongs to the transferrin family. (710 aa)
IL7RInterleukin-7 receptor subunit alpha. (459 aa)
STAB2Stabilin-2. (2166 aa)
LYZLysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. (148 aa)
DEFB119Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
CRPPentaxin. (225 aa)
TNFSF8Tumor necrosis factor ligand superfamily member 8; Belongs to the tumor necrosis factor family. (233 aa)
DEFB1Beta-defensin 1. (67 aa)
GBP4Guanylate-binding protein 4-like. (639 aa)
FAU40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (133 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (194 aa)
IL27RALOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha. (441 aa)
PGLYRP2N-acetylmuramoyl-L-alanine amidase. (574 aa)
ENSTSYP00000013827annotation not available (125 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (290 aa)
FGRTyrosine-protein kinase. (526 aa)
CHGAchromogranin-A isoform X4. (303 aa)
RPL3960S ribosomal protein L39. (51 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1040 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSTSYP00000021724annotation not available (61 aa)
DEFB136Beta-defensin 136. (78 aa)
ENSTSYP00000022646annotation not available (51 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein isoform X1. (228 aa)
LOC103259954Histone H2B; Belongs to the histone H2B family. (126 aa)
PLA2G1BPhospholipase A(2). (147 aa)
TAC1Tachykinin precursor 1. (130 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
ENSTSYP00000028986annotation not available (137 aa)
LYG2Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family. (191 aa)
CALCACalcitonin isoform X2. (142 aa)
LTALymphotoxin-alpha; Belongs to the tumor necrosis factor family. (205 aa)
PPP1R11Protein phosphatase 1 regulatory subunit 11. (126 aa)
ENSTSYP00000032235annotation not available (79 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1037 aa)
DMBT1Deleted in malignant brain tumors 1 protein. (1855 aa)
DROSHARibonuclease 3. (232 aa)
ENSTSYP00000034010annotation not available (126 aa)
ENSTSYP00000034265annotation not available (129 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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