node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GFAP | IL1B | ENSTSYP00000029305 | ENSTSYP00000007237 | Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.576 |
GFAP | IL6 | ENSTSYP00000029305 | ENSTSYP00000031540 | Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. | Interleukin-6. | 0.591 |
GFAP | TNF | ENSTSYP00000029305 | ENSTSYP00000027201 | Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.502 |
IL1B | GFAP | ENSTSYP00000007237 | ENSTSYP00000029305 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. | 0.576 |
IL1B | IL6 | ENSTSYP00000007237 | ENSTSYP00000031540 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Interleukin-6. | 0.793 |
IL1B | LYN | ENSTSYP00000007237 | ENSTSYP00000000562 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Tyrosine-protein kinase. | 0.490 |
IL1B | MECP2 | ENSTSYP00000007237 | ENSTSYP00000018942 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). | 0.595 |
IL1B | TNF | ENSTSYP00000007237 | ENSTSYP00000027201 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.932 |
IL1B | TSPO | ENSTSYP00000007237 | ENSTSYP00000031552 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Translocator protein. | 0.479 |
IL1B | VEGFC | ENSTSYP00000007237 | ENSTSYP00000001632 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.569 |
IL6 | GFAP | ENSTSYP00000031540 | ENSTSYP00000029305 | Interleukin-6. | Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. | 0.591 |
IL6 | IL1B | ENSTSYP00000031540 | ENSTSYP00000007237 | Interleukin-6. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.793 |
IL6 | LYN | ENSTSYP00000031540 | ENSTSYP00000000562 | Interleukin-6. | Tyrosine-protein kinase. | 0.532 |
IL6 | TNF | ENSTSYP00000031540 | ENSTSYP00000027201 | Interleukin-6. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.662 |
LYN | IL1B | ENSTSYP00000000562 | ENSTSYP00000007237 | Tyrosine-protein kinase. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.490 |
LYN | IL6 | ENSTSYP00000000562 | ENSTSYP00000031540 | Tyrosine-protein kinase. | Interleukin-6. | 0.532 |
LYN | TNF | ENSTSYP00000000562 | ENSTSYP00000027201 | Tyrosine-protein kinase. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.457 |
MECP2 | IL1B | ENSTSYP00000018942 | ENSTSYP00000007237 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.595 |
TNF | GFAP | ENSTSYP00000027201 | ENSTSYP00000029305 | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | Glial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. | 0.502 |
TNF | IL1B | ENSTSYP00000027201 | ENSTSYP00000007237 | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.932 |