(51 nodes) Endochondral bone morphogenesis network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MMP13	Collagenase 3. (471 aa)
	MATN1	Cartilage matrix protein. (447 aa)
	MMP16	Matrix metalloproteinase-16. (607 aa)
	COL13A1	Collagen alpha-1(XIII) chain. (713 aa)
	SERPINH1	Serpin H1; Belongs to the serpin family. (415 aa)
	HOXA11	Homeobox protein Hox-A11. (313 aa)
	IFT80	Intraflagellar transport protein 80 homolog. (777 aa)
	CER1	Cerberus. (266 aa)
	INPPL1	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1259 aa)
	BMP6	Bone morphogenetic protein 6. (513 aa)
	ANXA6	Annexin. (635 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (507 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (480 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (558 aa)
	COL2A1	Collagen alpha-1(II) chain. (1487 aa)
	MMP14	Matrix metalloproteinase-14 isoform X1. (582 aa)
	PEX7	Peroxisomal biogenesis factor 7. (323 aa)
	THBS3	Thrombospondin-3 isoform X1. (950 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (397 aa)
	BMP4	Bone morphogenetic protein 4 isoform X1. (409 aa)
	DSPP	Dentin sialophosphoprotein. (990 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
	FGFR3	Fibroblast growth factor receptor. (745 aa)
	MEF2D	LOW QUALITY PROTEIN: myocyte-specific enhancer factor 2D. (511 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
	COL27A1	Collagen alpha-1(XXVII) chain. (1840 aa)
	IMPAD1	Inositol monophosphatase 3. (167 aa)
	HOXD11	Homeobox protein Hox-D11. (155 aa)
	COL1A1	Collagen alpha-1(I) chain. (1462 aa)
	STC1	Stanniocalcin-1. (247 aa)
	AXIN2	Axin-2. (649 aa)
	NAB1	NGFI-A-binding protein 1. (487 aa)
	RARB	Retinoic acid receptor beta isoform X2. (448 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (656 aa)
	TRIP11	Thyroid receptor-interacting protein 11 isoform X1. (1918 aa)
	SCUBE2	Signal peptide, CUB and EGF-like domain-containing protein 2. (999 aa)
	COL3A1	Collagen alpha-1(III) chain. (1466 aa)
	NPPC	C-type natriuretic peptide. (129 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	RARG	Retinoic acid receptor gamma. (456 aa)
	DLX5	Distal-less homeobox 5. (289 aa)
	ENSTSYP00000035014	annotation not available (381 aa)
	PHOSPHO1	Phosphoethanolamine/phosphocholine phosphatase isoform X3. (267 aa)
	SCX	Basic helix-loop-helix transcription factor scleraxis. (199 aa)
	ENSTSYP00000031947	annotation not available (203 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X1. (483 aa)
	LOC103272774	Exostosin-2-like; Belongs to the glycosyltransferase 47 family. (476 aa)
	ALPL	Alkaline phosphatase. (524 aa)
	LOC103250817	Cartilage oligomeric matrix protein. (202 aa)
	SHOX2	Short stature homeobox protein 2 isoform X1. (331 aa)
	RARA	Retinoic acid receptor alpha isoform X2. (476 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPL	COL1A1	ENSTSYP00000029562	ENSTSYP00000018820	Alkaline phosphatase.	Collagen alpha-1(I) chain.	0.475
ALPL	PHOSPHO1	ENSTSYP00000029562	ENSTSYP00000034076	Alkaline phosphatase.	Phosphoethanolamine/phosphocholine phosphatase isoform X3.	0.472
ALPL	TRIP11	ENSTSYP00000029562	ENSTSYP00000012784	Alkaline phosphatase.	Thyroid receptor-interacting protein 11 isoform X1.	0.659
ATF2	MEF2C	ENSTSYP00000002396	ENSTSYP00000031858	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	Myocyte-specific enhancer factor 2C isoform X1.	0.415
ATF2	MEF2D	ENSTSYP00000002396	ENSTSYP00000025221	Cyclic AMP-dependent transcription factor ATF-2 isoform X1.	LOW QUALITY PROTEIN: myocyte-specific enhancer factor 2D.	0.415
AXIN2	BMPR1B	ENSTSYP00000017909	ENSTSYP00000002342	Axin-2.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.428
AXIN2	BMPR2	ENSTSYP00000017909	ENSTSYP00000024102	Axin-2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.444
AXIN2	IHH	ENSTSYP00000017909	ENSTSYP00000026991	Axin-2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.438
AXIN2	TGFBR2	ENSTSYP00000017909	ENSTSYP00000001810	Axin-2.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.443
BMP4	BMP6	ENSTSYP00000026121	ENSTSYP00000003332	Bone morphogenetic protein 4 isoform X1.	Bone morphogenetic protein 6.	0.939
BMP4	BMPR1B	ENSTSYP00000026121	ENSTSYP00000002342	Bone morphogenetic protein 4 isoform X1.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.991
BMP4	BMPR2	ENSTSYP00000026121	ENSTSYP00000024102	Bone morphogenetic protein 4 isoform X1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.974
BMP4	CER1	ENSTSYP00000026121	ENSTSYP00000005464	Bone morphogenetic protein 4 isoform X1.	Cerberus.	0.663
BMP4	COL2A1	ENSTSYP00000026121	ENSTSYP00000001712	Bone morphogenetic protein 4 isoform X1.	Collagen alpha-1(II) chain.	0.437
BMP4	DLX5	ENSTSYP00000026121	ENSTSYP00000009615	Bone morphogenetic protein 4 isoform X1.	Distal-less homeobox 5.	0.632
BMP4	FGF18	ENSTSYP00000026121	ENSTSYP00000025655	Bone morphogenetic protein 4 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.470
BMP4	IHH	ENSTSYP00000026121	ENSTSYP00000026991	Bone morphogenetic protein 4 isoform X1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.503
BMP4	TGFBR2	ENSTSYP00000026121	ENSTSYP00000001810	Bone morphogenetic protein 4 isoform X1.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.699
BMP6	BMP4	ENSTSYP00000003332	ENSTSYP00000026121	Bone morphogenetic protein 6.	Bone morphogenetic protein 4 isoform X1.	0.939
BMP6	BMPR1B	ENSTSYP00000003332	ENSTSYP00000002342	Bone morphogenetic protein 6.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.961