STRINGSTRING
RAPGEF2 RAPGEF2 NTRK1 NTRK1 PHB PHB CIB1 CIB1 NDRG4 NDRG4 NRG1 NRG1 MAPK3 MAPK3 ICAM1 ICAM1 APELA APELA ADCYAP1 ADCYAP1 RAP1A RAP1A MTURN MTURN ALKAL2 ALKAL2 PDGFRB PDGFRB IGF1 IGF1 PDGFB PDGFB CAVIN3 CAVIN3 ENSTSYP00000029960 ENSTSYP00000029960 HTR2A HTR2A NELFE NELFE GCG GCG LOC103265544 LOC103265544 TGFB1 TGFB1 AKAP12 AKAP12 PTEN PTEN LOC103250341 LOC103250341 ENSTSYP00000031763 ENSTSYP00000031763 SEMA7A SEMA7A AGER AGER CCL14 CCL14 C5AR1 C5AR1 NOTCH1 NOTCH1 ENSTSYP00000033115 ENSTSYP00000033115 SRC SRC PDGFA PDGFA CCN2 CCN2 BMP2 BMP2 CRKL CRKL PTK2B PTK2B SPRY2 SPRY2 CSF1R CSF1R MFHAS1 MFHAS1 CXCL17 CXCL17 BRAF BRAF GATA4 GATA4 CCL19 CCL19 FGFR2 FGFR2 SLAMF1 SLAMF1 OPRM1 OPRM1 ANGPT1 ANGPT1 MARCO MARCO PDGFC PDGFC ACKR3 ACKR3 SHC1 SHC1 CCL1 CCL1 ADRA1A ADRA1A NOTCH2 NOTCH2 LOC103261948 LOC103261948 EGFR EGFR RIPK2 RIPK2 HCRTR1 HCRTR1 CCL21 CCL21 CCL5 CCL5 ENSTSYP00000006677 ENSTSYP00000006677 CALCR CALCR ERBB4 ERBB4 CARD9 CARD9 BMPER BMPER FERMT2 FERMT2 P2RY1 P2RY1 PYCARD PYCARD THPO THPO LOC103250516 LOC103250516 IAPP IAPP HTR2B HTR2B FGA FGA FGG FGG NPTN NPTN PRXL2C PRXL2C PRKD2 PRKD2 ENSTSYP00000013878 ENSTSYP00000013878 HAVCR2 HAVCR2 MAP2K7 MAP2K7 TNFRSF11A TNFRSF11A CD74 CD74 SLC30A10 SLC30A10 TREM2 TREM2 LOC103263865 LOC103263865 MAP3K12 MAP3K12 LOC103250564 LOC103250564 GAS6 GAS6 CD36 CD36 MIF MIF DSTYK DSTYK LOC103271195 LOC103271195 NOD2 NOD2 RAMP3 RAMP3 CCL22 CCL22 ENSTSYP00000017967 ENSTSYP00000017967 CX3CL1 CX3CL1 DNAJC27 DNAJC27 MAP2K1 MAP2K1 LOC103276437 LOC103276437 CCL25 CCL25 FGF1 FGF1 LOC103267910 LOC103267910 ST5 ST5 SCIMP SCIMP SERPINF2 SERPINF2 TEK TEK CD44 CD44 FGF20 FGF20 FGF20-2 FGF20-2 ALKAL1 ALKAL1 LOC103254389 LOC103254389 NRXN1 NRXN1 FGF10 FGF10 CCL16 CCL16 PTPN22 PTPN22 PRKCZ PRKCZ FBXW7 FBXW7 APP APP TIRAP TIRAP ENSTSYP00000023371 ENSTSYP00000023371 ENSTSYP00000023558 ENSTSYP00000023558 CCL8 CCL8 CCR7 CCR7 FGF21 FGF21 PDE8A PDE8A TNFSF11 TNFSF11 FGFR3 FGFR3 FGF18 FGF18 MT3 MT3 GLIPR2 GLIPR2 FBXW9 FBXW9 BMP4 BMP4 CCL17 CCL17 ALOX15 ALOX15 PTPRC PTPRC CCL24 CCL24 NOD1 NOD1 ENSTSYP00000001212 ENSTSYP00000001212 PLA2G2A PLA2G2A RASGRP1 RASGRP1 NRP1 NRP1 ABL1 ABL1 LOC103265522 LOC103265522 CCL20 CCL20 PTPN11 PTPN11 FSHR FSHR CASR CASR PLA2G5 PLA2G5 TNFAIP8L3 TNFAIP8L3 FGB FGB HRAS HRAS LOC103266290 LOC103266290 PRKCA PRKCA GAREM1 GAREM1 KDR KDR GPNMB GPNMB NODAL NODAL CHI3L1 CHI3L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAPGEF2Rap guanine nucleotide exchange factor 2 isoform X1. (1659 aa)
NTRK1High affinity nerve growth factor receptor. (721 aa)
PHBProhibitin. (272 aa)
CIB1Calcium and integrin-binding protein 1 isoform X3. (191 aa)
NDRG4LOW QUALITY PROTEIN: protein NDRG4. (386 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
ICAM1Intercellular adhesion molecule 1. (281 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
ADCYAP1LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide. (176 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (90 aa)
ALKAL2ALK and LTK ligand 2. (162 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
CAVIN3Protein kinase C delta-binding protein isoform X2. (282 aa)
ENSTSYP00000029960annotation not available (129 aa)
HTR2A5-hydroxytryptamine receptor 2A isoform X1. (471 aa)
NELFENegative elongation factor E isoform X1. (390 aa)
GCGGlucagon. (180 aa)
LOC103265544D-dopachrome decarboxylase. (188 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
AKAP12A-kinase anchor protein 12. (1767 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC103250341C-C motif chemokine 13. (80 aa)
ENSTSYP00000031763annotation not available (161 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (666 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X2. (403 aa)
CCL14C-C motif chemokine. (112 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2339 aa)
ENSTSYP00000033115annotation not available (96 aa)
SRCTyrosine-protein kinase. (542 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
CCN2Connective tissue growth factor. (297 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
CRKLCrk-like protein. (303 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
SPRY2Protein sprouty homolog 2. (338 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (965 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1. (1047 aa)
CXCL17C-X-C motif chemokine 17. (122 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
GATA4Transcription factor GATA-4. (234 aa)
CCL19C-C motif chemokine 19. (102 aa)
FGFR2Fibroblast growth factor receptor 2 isoform X1. (615 aa)
SLAMF1Signaling lymphocytic activation molecule. (363 aa)
OPRM1Mu-type opioid receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (477 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
MARCOMacrophage receptor MARCO. (512 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SHC1SHC-transforming protein 1 isoform X1. (474 aa)
CCL1C-C motif chemokine 1. (100 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2211 aa)
LOC103261948Lymphotactin-like. (114 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2 isoform X1. (539 aa)
HCRTR1Orexin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
CCL21C-C motif chemokine 21. (131 aa)
CCL5C-C motif chemokine. (91 aa)
ENSTSYP00000006677annotation not available (117 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (492 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
CARD9Caspase recruitment domain-containing protein 9. (541 aa)
BMPERBMP-binding endothelial regulator protein. (685 aa)
FERMT2Fermitin family homolog 2. (664 aa)
P2RY1P2Y purinoceptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
THPOThrombopoietin isoform X1. (359 aa)
LOC103250516Discoidin domain-containing receptor 2-like. (168 aa)
IAPPIslet amyloid polypeptide. (89 aa)
HTR2B5-hydroxytryptamine receptor 2B isoform X1. (480 aa)
FGAFibrinogen alpha chain. (872 aa)
FGGFibrinogen gamma chain isoform X1. (461 aa)
NPTNNeuroplastin isoform X1. (397 aa)
PRXL2CThioredoxin-like protein AAED1. (209 aa)
PRKD2Serine/threonine-protein kinase D2. (853 aa)
ENSTSYP00000013878annotation not available (169 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (290 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (414 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (238 aa)
CD74HLA class II histocompatibility antigen gamma chain. (166 aa)
SLC30A10Zinc transporter 10. (485 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
LOC103263865Olfactory receptor. (211 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
LOC103250564Integrin beta; Belongs to the integrin beta chain family. (418 aa)
GAS6Growth arrest-specific protein 6. (440 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
DSTYKDual serine/threonine and tyrosine protein kinase isoform X1. (929 aa)
LOC103271195C-C motif chemokine. (91 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1040 aa)
RAMP3Receptor activity-modifying protein 3 isoform X2. (147 aa)
CCL22C-C motif chemokine. (93 aa)
ENSTSYP00000017967annotation not available (148 aa)
CX3CL1Fractalkine isoform X2. (402 aa)
DNAJC27dnaJ homolog subfamily C member 27 isoform X1. (273 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
LOC103276437Vascular endothelial growth factor receptor 3-like. (295 aa)
CCL25C-C motif chemokine 25. (145 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOC103267910Fibroblast growth factor receptor 2-like. (208 aa)
ST5Suppression of tumorigenicity 5 protein isoform X1. (1138 aa)
SCIMPSLP adapter and CSK-interacting membrane protein. (144 aa)
SERPINF2Alpha-2-antiplasmin; Belongs to the serpin family. (368 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
CD44CD44 antigen. (219 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
FGF20-2Fibroblast growth factor 20. (75 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
LOC103254389C-C motif chemokine 4 isoform X2. (98 aa)
NRXN1Neurexin-1 isoform X5. (1229 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CCL16C-C motif chemokine. (118 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (811 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (708 aa)
APPAmyloid beta A4 protein isoform X1. (765 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein isoform X1. (228 aa)
ENSTSYP00000023371annotation not available (665 aa)
ENSTSYP00000023558annotation not available (335 aa)
CCL8C-C motif chemokine. (100 aa)
CCR7C-C chemokine receptor type 7 isoform X1; Belongs to the G-protein coupled receptor 1 family. (378 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDE8APhosphodiesterase. (765 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (250 aa)
FGFR3Fibroblast growth factor receptor. (745 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (111 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. (149 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (409 aa)
CCL17C-C motif chemokine. (102 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (601 aa)
CCL24C-C motif chemokine 24. (116 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
ENSTSYP00000001212annotation not available (119 aa)
PLA2G2APhospholipase A(2). (144 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (792 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (927 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
LOC103265522N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase. (402 aa)
CCL20C-C motif chemokine. (96 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (532 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (620 aa)
CASRLOW QUALITY PROTEIN: extracellular calcium-sensing receptor. (1015 aa)
PLA2G5Phospholipase A(2). (138 aa)
TNFAIP8L3TNF alpha induced protein 8 like 3. (204 aa)
FGBFibrinogen beta chain isoform X1. (492 aa)
HRASGTPase HRas isoform X6. (189 aa)
LOC103266290Protein S100-A7-like. (99 aa)
PRKCAProtein kinase C. (614 aa)
GAREM1GRB2-associated and regulator of MAPK protein 1. (788 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GPNMBTransmembrane glycoprotein NMB isoform X3. (557 aa)
NODALNodal homolog. (332 aa)
CHI3L1Chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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