(19 nodes) interleukin-1-mediated signaling pathway network (Carlito syrichta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IRAK1	Interleukin-1 receptor-associated kinase 1. (618 aa)
	RELA	Transcription factor p65. (519 aa)
	TNIP2	TNFAIP3-interacting protein 2. (366 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (512 aa)
	RPS6KA5	Non-specific serine/threonine protein kinase. (594 aa)
	ST18	Suppression of tumorigenicity 18 protein. (1043 aa)
	IL1R1	Interleukin-1 receptor type 1. (573 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1135 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
	ENSTSYP00000006680	annotation not available (255 aa)
	IL1RL2	Interleukin-1 receptor-like 2. (573 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
	IRAK2	Interleukin-1 receptor-associated kinase-like 2. (626 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	IRAK3	Interleukin-1 receptor-associated kinase 3. (549 aa)
	MAPK3	Mitogen-activated protein kinase. (363 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
	TOLLIP	Toll-interacting protein. (238 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGR1	MAPK3	ENSTSYP00000030457	ENSTSYP00000027878	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.	Mitogen-activated protein kinase.	0.899
EGR1	RELA	ENSTSYP00000030457	ENSTSYP00000024432	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.	Transcription factor p65.	0.431
ENSTSYP00000006680	IKBKB	ENSTSYP00000006680	ENSTSYP00000003091	annotation not available	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.621
ENSTSYP00000006680	IL1B	ENSTSYP00000006680	ENSTSYP00000007237	annotation not available	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.808
ENSTSYP00000006680	IL1R1	ENSTSYP00000006680	ENSTSYP00000008996	annotation not available	Interleukin-1 receptor type 1.	0.983
ENSTSYP00000006680	IL1RL2	ENSTSYP00000006680	ENSTSYP00000004986	annotation not available	Interleukin-1 receptor-like 2.	0.917
ENSTSYP00000006680	IRAK1	ENSTSYP00000006680	ENSTSYP00000030974	annotation not available	Interleukin-1 receptor-associated kinase 1.	0.992
ENSTSYP00000006680	IRAK2	ENSTSYP00000006680	ENSTSYP00000002064	annotation not available	Interleukin-1 receptor-associated kinase-like 2.	0.988
ENSTSYP00000006680	IRAK3	ENSTSYP00000006680	ENSTSYP00000001517	annotation not available	Interleukin-1 receptor-associated kinase 3.	0.793
ENSTSYP00000006680	IRAK4	ENSTSYP00000006680	ENSTSYP00000001941	annotation not available	Interleukin-1 receptor-associated kinase 4.	0.993
ENSTSYP00000006680	MAPK3	ENSTSYP00000006680	ENSTSYP00000027878	annotation not available	Mitogen-activated protein kinase.	0.463
ENSTSYP00000006680	RELA	ENSTSYP00000006680	ENSTSYP00000024432	annotation not available	Transcription factor p65.	0.716
ENSTSYP00000006680	TOLLIP	ENSTSYP00000006680	ENSTSYP00000027020	annotation not available	Toll-interacting protein.	0.922
ENSTSYP00000006680	TRAF6	ENSTSYP00000006680	ENSTSYP00000016353	annotation not available	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.987
IKBKB	ENSTSYP00000006680	ENSTSYP00000003091	ENSTSYP00000006680	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	annotation not available	0.621
IKBKB	IL1B	ENSTSYP00000003091	ENSTSYP00000007237	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.614
IKBKB	IL1R1	ENSTSYP00000003091	ENSTSYP00000008996	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Interleukin-1 receptor type 1.	0.432
IKBKB	IRAK1	ENSTSYP00000003091	ENSTSYP00000030974	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Interleukin-1 receptor-associated kinase 1.	0.838
IKBKB	IRAK2	ENSTSYP00000003091	ENSTSYP00000002064	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Interleukin-1 receptor-associated kinase-like 2.	0.824
IKBKB	IRAK3	ENSTSYP00000003091	ENSTSYP00000001517	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	Interleukin-1 receptor-associated kinase 3.	0.458