STRINGSTRING
PSPN PSPN FGF16 FGF16 SNX4 SNX4 LYN LYN VAV3 VAV3 IL12A IL12A FRS3 FRS3 BTC BTC VEGFC VEGFC IRAK4 IRAK4 IL21 IL21 CD2AP CD2AP IL36G IL36G SNX2 SNX2 PTPRJ PTPRJ SOCS5 SOCS5 PIBF1 PIBF1 EREG EREG FLRT3 FLRT3 FLRT2 FLRT2 KLB KLB ENSTSYP00000006680 ENSTSYP00000006680 ERBB4 ERBB4 MYD88 MYD88 PYCARD PYCARD IL37 IL37 IL36RN IL36RN IL1B IL1B VEGFD VEGFD PDCL2 PDCL2 EFEMP1 EFEMP1 CSF2 CSF2 GLMN GLMN ADAM17 ADAM17 EGF EGF FER FER CDH5 CDH5 IL4 IL4 IL1R1 IL1R1 AREG AREG JAK2 JAK2 IL5 IL5 LOC103276767 LOC103276767 PDGFC PDGFC LINGO2 LINGO2 TSLP TSLP HBEGF HBEGF MS4A1 MS4A1 IL1RN IL1RN IL1A IL1A IL1F10 IL1F10 PDGFD PDGFD AGR2 AGR2 ERAP1 ERAP1 IL36A IL36A GDNF GDNF ENSTSYP00000013295 ENSTSYP00000013295 FGF5 FGF5 NPTN NPTN IL9 IL9 FYN FYN PDCL3 PDCL3 FGF6 FGF6 FGF3 FGF3 FGF7 FGF7 ENSTSYP00000016245 ENSTSYP00000016245 CYSTM1 CYSTM1 TNK2 TNK2 LOC103250564 LOC103250564 IL6ST IL6ST FRS2 FRS2 IL7 IL7 FGF1 FGF1 FGF20 FGF20 FGF20-2 FGF20-2 FGF17 FGF17 NRXN1 NRXN1 CCDC88A CCDC88A TRIP6 TRIP6 FGF10 FGF10 ECM1 ECM1 TGFA TGFA ERN1 ERN1 FGF9 FGF9 RNF41 RNF41 NCSTN NCSTN IL1RAP IL1RAP FGF21 FGF21 ATXN2 ATXN2 KL KL FGF18 FGF18 CSF3 CSF3 GATA3 GATA3 TOLLIP TOLLIP CBLC CBLC LINGO1 LINGO1 VEGFB VEGFB VAV2 VAV2 DAB2IP DAB2IP IL2 IL2 CADM4 CADM4 PDGFRB PDGFRB LOC103269101 LOC103269101 PDGFB PDGFB FAM83B FAM83B ARTN ARTN SDCBP SDCBP ITGA5 ITGA5 EPGN EPGN IL6 IL6 PGF PGF PSEN1 PSEN1 GRAP GRAP GRB2 GRB2 ENSTSYP00000033115 ENSTSYP00000033115 SRC SRC PDGFA PDGFA LOC103258694 LOC103258694 HIP1 HIP1 ESM1 ESM1 CNTF CNTF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSPNPersephin. (107 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
SNX4Sorting nexin-4 isoform X2. (450 aa)
LYNTyrosine-protein kinase. (512 aa)
VAV3Guanine nucleotide exchange factor VAV3-like. (514 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
FRS3Fibroblast growth factor receptor substrate 3 isoform X1. (492 aa)
BTCProbetacellulin. (178 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (407 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
CD2APCD2-associated protein. (638 aa)
IL36GInterleukin-1. (154 aa)
SNX2Sorting nexin-2 isoform X2. (519 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta. (1260 aa)
SOCS5Suppressor of cytokine signaling 5 isoform X1. (515 aa)
PIBF1Progesterone-induced-blocking factor 1. (756 aa)
EREGProepiregulin. (167 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3. (649 aa)
FLRT2Leucine-rich repeat transmembrane protein FLRT2. (660 aa)
KLBBeta-klotho. (835 aa)
ENSTSYP00000006680annotation not available (255 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
IL37Interleukin-1. (217 aa)
IL36RNInterleukin-1. (155 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (351 aa)
PDCL2Phosducin-like protein 2. (241 aa)
EFEMP1EGF-containing fibulin-like extracellular matrix protein 1. (492 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
GLMNGlomulin isoform X1. (345 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (824 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
FERTyrosine-protein kinase. (647 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (786 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (142 aa)
IL1R1Interleukin-1 receptor type 1. (573 aa)
AREGAmphiregulin isoform X1. (270 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
LOC103276767Membrane-spanning 4-domains subfamily A member 4A-like. (171 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LINGO2Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2. (606 aa)
TSLPThymic stromal lymphopoietin. (291 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
MS4A1B-lymphocyte antigen CD20. (294 aa)
IL1RNInterleukin-1. (159 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
IL1F10Interleukin-1. (152 aa)
PDGFDPlatelet-derived growth factor D. (370 aa)
AGR2Anterior gradient protein 2 homolog isoform X1. (187 aa)
ERAP1Aminopeptidase. (937 aa)
IL36AInterleukin-1. (157 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X3. (211 aa)
ENSTSYP00000013295annotation not available (83 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
NPTNNeuroplastin isoform X1. (397 aa)
IL9Interleukin-9. (144 aa)
FYNTyrosine-protein kinase. (537 aa)
PDCL3Phosducin-like protein 3. (241 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ENSTSYP00000016245annotation not available (315 aa)
CYSTM1Cysteine-rich and transmembrane domain-containing protein 1. (96 aa)
TNK2Activated CDC42 kinase 1 isoform X5; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1063 aa)
LOC103250564Integrin beta; Belongs to the integrin beta chain family. (418 aa)
IL6STInterleukin-6 receptor subunit beta. (917 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
FGF20-2Fibroblast growth factor 20. (75 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
NRXN1Neurexin-1 isoform X5. (1229 aa)
CCDC88AGirdin isoform X4. (1874 aa)
TRIP6Thyroid receptor-interacting protein 6 isoform X1. (475 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ECM1Extracellular matrix protein 1 isoform X2. (544 aa)
TGFATransforming growth factor alpha. (164 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (949 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform X1. (317 aa)
NCSTNNicastrin isoform X1. (708 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform X1. (687 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATXN2Ataxin-2 isoform X7. (1313 aa)
KLKlotho; Belongs to the glycosyl hydrolase 1 family. (972 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
CSF3Granulocyte colony-stimulating factor isoform X2. (204 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (436 aa)
TOLLIPToll-interacting protein. (238 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (337 aa)
LINGO1Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1. (619 aa)
VEGFBVascular endothelial growth factor B. (181 aa)
VAV2Guanine nucleotide exchange factor VAV2. (810 aa)
DAB2IPDisabled homolog 2-interacting protein. (1088 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
CADM4Cell adhesion molecule 4. (389 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
LOC103269101Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (301 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
FAM83BProtein FAM83B. (1011 aa)
ARTNArtemin. (154 aa)
SDCBPSyntenin-1 isoform X2. (302 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1053 aa)
EPGNEpigen isoform X1. (153 aa)
IL6Interleukin-6. (209 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
GRAPGRB2-related adapter protein. (188 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
ENSTSYP00000033115annotation not available (96 aa)
SRCTyrosine-protein kinase. (542 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
LOC103258694Glomulin-like. (97 aa)
HIP1Huntingtin-interacting protein 1. (1008 aa)
ESM1Endothelial cell-specific molecule 1 isoform X1. (185 aa)
CNTFCiliary neurotrophic factor. (200 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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