STRINGSTRING
PECAM1 PECAM1 PDGFB PDGFB PDGFRB PDGFRB BMP4 BMP4 CD34 CD34 GPR4 GPR4 TEK TEK OSR1 OSR1 NOTCH2 NOTCH2 NOTCH3 NOTCH3 ANGPT2 ANGPT2 ANGPT1 ANGPT1 EGR1 EGR1 EDNRA EDNRA NOTCH1 NOTCH1 TCF21 TCF21
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PECAM1Platelet endothelial cell adhesion molecule. (737 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (409 aa)
CD34Hematopoietic progenitor cell antigen CD34. (383 aa)
GPR4G-protein coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (373 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
OSR1LOW QUALITY PROTEIN: protein odd-skipped-related 1. (266 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2211 aa)
NOTCH3Neurogenic locus notch homolog protein 3. (2169 aa)
ANGPT2Angiopoietin-2 isoform X1. (495 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2339 aa)
TCF21LOW QUALITY PROTEIN: transcription factor 21. (178 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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