STRINGSTRING
OSR2 OSR2 HOXB4 HOXB4 FGF10 FGF10 SIX2 SIX2 FGF9 FGF9 RUNX2 RUNX2 PRRX1 PRRX1 TP53 TP53 WNT5A WNT5A ERCC2 ERCC2 SFN SFN YJEFN3 YJEFN3 KDF1 KDF1 OVOL1 OVOL1 CD34 CD34 NES NES WNT11 WNT11 WNT1 WNT1 HOXA3 HOXA3 TP63 TP63 RNF43 RNF43 RUNX1 RUNX1 SFRP2 SFRP2 BABAM1 BABAM1 ENSTSYP00000027119 ENSTSYP00000027119 IFT20 IFT20 SCRG1 SCRG1 KDR KDR TIAL1 TIAL1 ARIH2 ARIH2 YTHDF2 YTHDF2 CTC1 CTC1 PTCH1 PTCH1 SHB SHB BRCA2 BRCA2 CEP120 CEP120 NFIB NFIB TBX3 TBX3 GLI3 GLI3 NF1 NF1 CTNNB1 CTNNB1 RARG RARG HMX2 HMX2 ETV6 ETV6 XRCC5 XRCC5 ELL3 ELL3 WNT3 WNT3 SHH SHH WNT7B WNT7B YAP1 YAP1 RARB RARB AXIN2 AXIN2 MECOM MECOM IRF6 IRF6 SHOX2 SHOX2 CD109 CD109 NR2E1 NR2E1 TGFB1 TGFB1 BYSL BYSL SNAI2 SNAI2 WNT2B WNT2B WNT10B WNT10B SART3 SART3 TRIM71 TRIM71 ENSTSYP00000035014 ENSTSYP00000035014 CDKN2C CDKN2C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OSR2Protein odd-skipped-related 2 isoform X2. (312 aa)
HOXB4Homeobox protein Hox-A4. (247 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SIX2LOW QUALITY PROTEIN: homeobox protein SIX2. (290 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
RUNX2Runt-related transcription factor 2. (507 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform X1. (245 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ERCC2LOW QUALITY PROTEIN: TFIIH basal transcription factor complex helicase XPD subunit. (668 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (228 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
OVOL1Putative transcription factor Ovo-like 1. (258 aa)
CD34Hematopoietic progenitor cell antigen CD34. (383 aa)
NESNestin; Belongs to the intermediate filament family. (1505 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
HOXA3Homeobox protein Hox-A3. (419 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (690 aa)
RNF43E3 ubiquitin-protein ligase RNF43 isoform X1. (783 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (461 aa)
SFRP2Secreted frizzled-related protein 2. (301 aa)
BABAM1BRISC and BRCA1-A complex member 1 isoform X1. (321 aa)
ENSTSYP00000027119annotation not available (107 aa)
IFT20Intraflagellar transport protein 20 homolog isoform X2. (154 aa)
SCRG1Scrapie-responsive protein 1. (98 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
TIAL1Nucleolysin TIAR isoform X1. (384 aa)
ARIH2RBR-type E3 ubiquitin transferase. (498 aa)
YTHDF2YTH domain-containing family protein 2 isoform X1. (586 aa)
CTC1CST complex subunit CTC1. (1222 aa)
PTCH1Protein patched homolog 1. (1318 aa)
SHBSH2 domain-containing adapter protein B. (270 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3391 aa)
CEP120Centrosomal protein of 120 kDa isoform X1. (986 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (560 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (713 aa)
GLI3LOW QUALITY PROTEIN: transcriptional activator GLI3. (1533 aa)
NF1Neurofibromin isoform X2. (2839 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
RARGRetinoic acid receptor gamma. (456 aa)
HMX2H6 family homeobox 2. (248 aa)
ETV6Transcription factor ETV6. (442 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
ELL3RNA polymerase II elongation factor ELL3. (394 aa)
WNT3Wnt family member 3. (239 aa)
SHHSonic hedgehog signaling molecule. (368 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (326 aa)
RARBRetinoic acid receptor beta isoform X2. (448 aa)
AXIN2Axin-2. (649 aa)
MECOMMDS1 and EVI1 complex locus protein EVI1. (1218 aa)
IRF6Interferon regulatory factor 6 isoform X1. (467 aa)
SHOX2Short stature homeobox protein 2 isoform X1. (331 aa)
CD109CD109 antigen. (1470 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
BYSLBystin. (437 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SART3Squamous cell carcinoma antigen recognized by T-cells 3 isoform X2. (964 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71. (584 aa)
ENSTSYP00000035014annotation not available (381 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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