(93 nodes) Positive regulation of canonical Wnt signaling pathway network (Carlito syrichta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ARNTL	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3. (628 aa)
	LOC103275739	Casein kinase I; Belongs to the protein kinase superfamily. (416 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	ENSTSYP00000026316	annotation not available (161 aa)
	SFRP2	Secreted frizzled-related protein 2. (301 aa)
	SEMA5A	semaphorin-5A. (335 aa)
	TRPM4	Transient receptor potential cation channel subfamily M member 4. (978 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ENSTSYP00000030211	annotation not available (133 aa)
	DKK2	Dickkopf-related protein 2. (259 aa)
	WLS	Protein wntless homolog isoform X2. (543 aa)
	DAAM2	Disheveled-associated activator of morphogenesis 2. (1077 aa)
	CCAR2	Cell cycle and apoptosis regulator protein 2 isoform X1. (923 aa)
	TMEM9	LOW QUALITY PROTEIN: transmembrane protein 9. (183 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (490 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	GSKIP	GSK3-beta interaction protein. (139 aa)
	AMER1	APC membrane recruitment protein 1. (789 aa)
	ENSTSYP00000034022	annotation not available (114 aa)
	TTC21B	Tetratricopeptide repeat protein 21B. (1316 aa)
	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2. (2527 aa)
	XIAP	E3 ubiquitin-protein ligase XIAP. (497 aa)
	RECK	Reversion-inducing cysteine-rich protein with Kazal motifs isoform X1. (974 aa)
	EDA	ectodysplasin-A; Belongs to the tumor necrosis factor family. (259 aa)
	SMURF2	E3 ubiquitin-protein ligase. (662 aa)
	SCEL	Sciellin. (682 aa)
	PPM1A	Protein phosphatase 1A isoform X1. (417 aa)
	KANK1	KN motif and ankyrin repeat domain-containing protein 1. (1353 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1102 aa)
	GPC5	Glypican-5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (320 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (946 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
	LGR5	Leucine-rich repeat-containing G-protein coupled receptor 5. (907 aa)
	TMEM198	Transmembrane protein 198. (360 aa)
	EGFR	Receptor protein-tyrosine kinase. (1180 aa)
	USP34	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 34; Belongs to the peptidase C19 family. (3525 aa)
	CDH3	Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (825 aa)
	TBL1XR1	F-box-like/WD repeat-containing protein TBL1XR1 isoform X1. (514 aa)
	CAPRIN2	Caprin-2 isoform X2. (1057 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
	ZEB2	Zinc finger E-box-binding homeobox 2 isoform X1. (1241 aa)
	VCP	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (806 aa)
	RPS12	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
	ENSTSYP00000009405	Abnormal spindle microtubule assembly. (3463 aa)
	USP8	Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1117 aa)
	GPRC5B	G-protein coupled receptor family C group 5 member B isoform X1. (404 aa)
	LOC103253126	Protein phosphatase 1B. (327 aa)
	FGFR2	Fibroblast growth factor receptor 2 isoform X1. (615 aa)
	DLX5	Distal-less homeobox 5. (289 aa)
	FZD9	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (365 aa)
	RNF220	E3 ubiquitin-protein ligase RNF220 isoform X1. (566 aa)
	LRRK1	Leucine-rich repeat serine/threonine-protein kinase 1. (2014 aa)
	PPM1N	LOW QUALITY PROTEIN: probable protein phosphatase 1N. (368 aa)
	UBR5	E3 ubiquitin-protein ligase UBR5. (2802 aa)
	PRDM15	PR domain zinc finger protein 15. (1140 aa)
	CTDNEP1	CTD nuclear envelope phosphatase 1 isoform X1. (244 aa)
	PTK7	Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	ADGRA2	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1076 aa)
	RSPO1	R-spondin-1. (263 aa)
	LYPD6	ly6/PLAUR domain-containing protein 6. (171 aa)
	PPM1B	Protein phosphatase 1B. (157 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X1. (326 aa)
	WNK1	Serine/threonine-protein kinase WNK1 isoform X1. (2624 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1166 aa)
	NLE1	Notchless protein homolog 1 isoform X1. (486 aa)
	COL1A1	Collagen alpha-1(I) chain. (1462 aa)
	JUP	Junction plakoglobin isoform X1. (745 aa)
	LOC103267910	Fibroblast growth factor receptor 2-like. (208 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	USP47	Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1375 aa)
	WNK2	Serine/threonine-protein kinase WNK2. (2142 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	RNF146	E3 ubiquitin-protein ligase RNF146 isoform X1. (358 aa)
	ATP6AP2	Renin receptor isoform X1. (301 aa)
	PLEKHA4	LOW QUALITY PROTEIN: pleckstrin homology domain-containing family A member 4. (769 aa)
	LGR6	Leucine-rich repeat-containing G-protein coupled receptor 6. (824 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
	SFRP4	Secreted frizzled-related protein 4. (359 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	FAM53B	Protein FAM53B. (423 aa)
	LOC103266409	Transmembrane protein 198-like. (350 aa)
	ENSTSYP00000024067	annotation not available (148 aa)
	RSPO2	R-spondin-2. (211 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
	JRK	Jrk helix-turn-helix protein. (561 aa)
	ENSTSYP00000025774	annotation not available (137 aa)
	ENSTSYP00000025851	annotation not available (98 aa)
	ENSTSYP00000033096	annotation not available (490 aa)
	GID8	Glucose-induced degradation protein 8 homolog isoform X2. (228 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRA2	EGFR	ENSTSYP00000012497	ENSTSYP00000005737	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Receptor protein-tyrosine kinase.	0.456
ADGRA2	PTK7	ENSTSYP00000012497	ENSTSYP00000012155	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.564
ADGRA2	RECK	ENSTSYP00000012497	ENSTSYP00000002098	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Reversion-inducing cysteine-rich protein with Kazal motifs isoform X1.	0.475
AMER1	JUP	ENSTSYP00000033815	ENSTSYP00000019044	APC membrane recruitment protein 1.	Junction plakoglobin isoform X1.	0.901
AMER1	WNT3A	ENSTSYP00000033815	ENSTSYP00000026275	APC membrane recruitment protein 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.565
ARNTL	BAMBI	ENSTSYP00000032427	ENSTSYP00000019742	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.472
ARNTL	LOC103275739	ENSTSYP00000032427	ENSTSYP00000032323	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3.	Casein kinase I; Belongs to the protein kinase superfamily.	0.989
BAMBI	ARNTL	ENSTSYP00000019742	ENSTSYP00000032427	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3.	0.472
BAMBI	EGF	ENSTSYP00000019742	ENSTSYP00000008584	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.537
BAMBI	FZD9	ENSTSYP00000019742	ENSTSYP00000009934	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family.	0.864
BAMBI	SFRP2	ENSTSYP00000019742	ENSTSYP00000026394	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Secreted frizzled-related protein 2.	0.756
BAMBI	SFRP4	ENSTSYP00000019742	ENSTSYP00000022882	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Secreted frizzled-related protein 4.	0.674
BAMBI	SMAD3	ENSTSYP00000019742	ENSTSYP00000029923	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.676
BAMBI	TGFB1	ENSTSYP00000019742	ENSTSYP00000030862	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.771
CAV1	EGF	ENSTSYP00000032202	ENSTSYP00000008584	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.560
CAV1	EGFR	ENSTSYP00000032202	ENSTSYP00000005737	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein-tyrosine kinase.	0.928
CAV1	JUP	ENSTSYP00000032202	ENSTSYP00000019044	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin isoform X1.	0.589
CAV1	SMAD3	ENSTSYP00000032202	ENSTSYP00000029923	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Mothers against decapentaplegic homolog.	0.406
CAV1	SRC	ENSTSYP00000032202	ENSTSYP00000033233	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.902
CAV1	VCP	ENSTSYP00000032202	ENSTSYP00000008855	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family.	0.564