STRINGSTRING
NUDT12 NUDT12 XRN2 XRN2 DCP2 DCP2 DIS3 DIS3 NOP14 NOP14 AGO2 AGO2 TSEN15 TSEN15 RPS21 RPS21 DCPS DCPS RNASEK RNASEK ZGRF1 ZGRF1 EXO1 EXO1 PNPT1 PNPT1 FCF1 FCF1 PIWIL1 PIWIL1 LOC103263896 LOC103263896 ELAC1 ELAC1 NME1 NME1 LACTB2 LACTB2 OGG1 OGG1 ENDOV ENDOV PNLDC1 PNLDC1 APEX2 APEX2 MRPL44 MRPL44 DBR1 DBR1 ELAC2 ELAC2 PELO PELO SND1 SND1 EDC3 EDC3 G3BP1 G3BP1 DCLRE1C DCLRE1C DNASE1L1 DNASE1L1 CNOT6 CNOT6 SPO11 SPO11 MRE11 MRE11 N4BP2 N4BP2 POP4 POP4 SMG6 SMG6 UTP20 UTP20 POP1 POP1 RIDA RIDA NOB1 NOB1 CPSF3 CPSF3 RAD1 RAD1 ZRANB3 ZRANB3 RNASET2 RNASET2 XRN1 XRN1 EXOSC9 EXOSC9 ZNRD1 ZNRD1 PMS2 PMS2 ERI3 ERI3 EXD2 EXD2 DICER1 DICER1 CCDC36 CCDC36 DIS3L DIS3L ENPP2 ENPP2 UTP23 UTP23 NOL9 NOL9 UBXN8 UBXN8 BMS1 BMS1 DNA2 DNA2 ERCC4 ERCC4 C12orf10 C12orf10 N4BP2L1 N4BP2L1 DCLRE1A DCLRE1A TUT1 TUT1 PCF11 PCF11 POLR3K POLR3K GEN1 GEN1 HORMAD1 HORMAD1 PARN PARN KIAA0391 KIAA0391 DCP1A DCP1A SAMHD1 SAMHD1 RNASEL RNASEL FANCM FANCM ERN2 ERN2 N4BP1 N4BP1 NOCT NOCT ERN1 ERN1 TSEN2 TSEN2 ENSTSYP00000021997 ENSTSYP00000021997 ENSTSYP00000021999 ENSTSYP00000021999 TREX1 TREX1 ENSTSYP00000022043 ENSTSYP00000022043 PLD4 PLD4 ERI1 ERI1 RNASEH2A RNASEH2A ENSTSYP00000023156 ENSTSYP00000023156 POLD1 POLD1 DDX1 DDX1 ENPP3 ENPP3 ZC3H12A ZC3H12A TDP2 TDP2 PDE12 PDE12 ERCC2 ERCC2 CNOT1 CNOT1 FEN1 FEN1 LAS1L LAS1L DXO DXO DCLRE1B DCLRE1B ZC3H12C ZC3H12C INTS11 INTS11 EME2 EME2 TSN TSN B4GALNT3 B4GALNT3 BOP1 BOP1 PNKP PNKP ENSTSYP00000028242 ENSTSYP00000028242 ENSTSYP00000028606 ENSTSYP00000028606 EXOSC4 EXOSC4 NYNRIN NYNRIN RAD9A RAD9A LOC103269101 LOC103269101 ENSTSYP00000029178 ENSTSYP00000029178 LOC103276852 LOC103276852 EXOG EXOG ENSTSYP00000029954 ENSTSYP00000029954 DNASE1L2 DNASE1L2 EXOSC2 EXOSC2 LOC103255792 LOC103255792 USB1 USB1 ENSTSYP00000031322 ENSTSYP00000031322 LRRC27 LRRC27 KHNYN KHNYN APTX APTX DNASE2 DNASE2 TBL3 TBL3 ENSTSYP00000032963 ENSTSYP00000032963 YBEY YBEY NTHL1 NTHL1 MUS81 MUS81 ENSTSYP00000033666 ENSTSYP00000033666 HAUS7 HAUS7 EXOSC10 EXOSC10 DROSHA DROSHA DFFB DFFB CNOT2 CNOT2 PAN2 PAN2 ENSTSYP00000034469 ENSTSYP00000034469 ZC3H12D ZC3H12D CNOT7 CNOT7 ERCC5 ERCC5 APEX1 APEX1 LOC103273533 LOC103273533 LOC103275081 LOC103275081 CUNH11orf80 CUNH11orf80 LOC103260808 LOC103260808 POLR2I POLR2I ENSTSYP00000019247 ENSTSYP00000019247 SLFNL1 SLFNL1 DNASE1 DNASE1 CNOT8 CNOT8 PAN3 PAN3 ERCC1 ERCC1 REXO2 REXO2 TATDN1 TATDN1 ENSTSYP00000018615 ENSTSYP00000018615 ENSTSYP00000018417 ENSTSYP00000018417 ANKRD31 ANKRD31 ENSTSYP00000018140 ENSTSYP00000018140 REXO4 REXO4 ISG20 ISG20 TSEN34 TSEN34 MEIOB MEIOB HELZ2 HELZ2 CPSF4L CPSF4L RRP36 RRP36 ENSTSYP00000016703 ENSTSYP00000016703 CPSF4 CPSF4 TRIR TRIR MFF MFF LOC103268596 LOC103268596 ISG20L2 ISG20L2 ASTE1 ASTE1 LOC103256015 LOC103256015 RPP40 RPP40 SLX1A SLX1A EXOSC5 EXOSC5 ENSTSYP00000014741 ENSTSYP00000014741 TDP1 TDP1 ENSTSYP00000014426 ENSTSYP00000014426 POP7 POP7 ENDOU ENDOU POP5 POP5 ENSTSYP00000014227 ENSTSYP00000014227 PIWIL2 PIWIL2 TATDN3 TATDN3 CPSF1 CPSF1 NUDT21 NUDT21 ANGEL2 ANGEL2 FAN1 FAN1 NOP9 NOP9 AGO4 AGO4 RPP30 RPP30 DNASE2B DNASE2B MEI4 MEI4 TTC38 TTC38 EXOSC3 EXOSC3 AZGP1 AZGP1 DNASE1L3 DNASE1L3 MARF1 MARF1 LOC103255908 LOC103255908 RPP14 RPP14 EXOSC8 EXOSC8 ABT1 ABT1 RNASEH1 RNASEH1 POLG POLG RBBP8 RBBP8 WRN WRN AEN AEN EME1 EME1 EXOSC7 EXOSC7 ERI2 ERI2 XPA XPA NCBP1 NCBP1 ANGEL1 ANGEL1 AGO3 AGO3 DIS3L2 DIS3L2 KRI1 KRI1 TOE1 TOE1 ZC3H12B ZC3H12B MBD4 MBD4 EDC4 EDC4 MGME1 MGME1 SWT1 SWT1 POLE POLE PLD3 PLD3 PGBD5 PGBD5 PPP1R8 PPP1R8 CPSF7 CPSF7 ATAD5 ATAD5 ENSTSYP00000008894 ENSTSYP00000008894 RCL1 RCL1 TATDN2 TATDN2 CNOT6L CNOT6L CPSF2 CPSF2 RAD51C RAD51C RPS3 RPS3 CPSF6 CPSF6 ENPP1 ENPP1 DCP1B DCP1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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NUDT12Peroxisomal NADH pyrophosphatase NUDT12 isoform X1. (462 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (949 aa)
DCP2m7GpppN-mRNA hydrolase isoform X1. (422 aa)
DIS3Exosome complex exonuclease RRP44 isoform X1; Belongs to the RNR ribonuclease family. (954 aa)
NOP14Nucleolar protein 14. (849 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (876 aa)
TSEN15tRNA-splicing endonuclease subunit Sen15 isoform X2. (117 aa)
RPS2140S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
DCPSm7GpppX diphosphatase isoform X1. (337 aa)
RNASEKRibonuclease kappa isoform X1. (131 aa)
ZGRF1Protein ZGRF1. (2113 aa)
EXO1Exonuclease 1 isoform X1. (846 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1. (784 aa)
FCF1rRNA-processing protein FCF1 homolog. (198 aa)
PIWIL1Piwi-like protein 1; Belongs to the argonaute family. (861 aa)
LOC103263896Ribonuclease P/MRP protein subunit POP5-like. (97 aa)
ELAC1Zinc phosphodiesterase ELAC protein 1. (364 aa)
NME1Nucleoside diphosphate kinase. (146 aa)
LACTB2Endoribonuclease LACTB2. (288 aa)
OGG1N-glycosylase/DNA lyase isoform X2. (373 aa)
ENDOVEndonuclease V isoform X1. (285 aa)
PNLDC1poly(A)-specific ribonuclease PNLDC1. (531 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (513 aa)
MRPL4439S ribosomal protein L44, mitochondrial. (332 aa)
DBR1Lariat debranching enzyme isoform X1. (547 aa)
ELAC2Zinc phosphodiesterase ELAC protein 2 isoform X1. (820 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
SND1Staphylococcal nuclease domain-containing protein 1. (593 aa)
EDC3Enhancer of mRNA-decapping protein 3. (508 aa)
G3BP1Ras GTPase-activating protein-binding protein 1. (466 aa)
DCLRE1CLOW QUALITY PROTEIN: protein artemis. (672 aa)
DNASE1L1Deoxyribonuclease; Belongs to the DNase I family. (306 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (557 aa)
SPO11Meiotic recombination protein SPO11 isoform X1. (396 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (699 aa)
N4BP2NEDD4-binding protein 2. (1762 aa)
POP4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (220 aa)
SMG6Telomerase-binding protein EST1A isoform X1. (1419 aa)
UTP20Small subunit processome component 20 homolog. (2786 aa)
POP1Ribonucleases P/MRP protein subunit POP1. (1024 aa)
RIDARibonuclease UK114 isoform X1. (136 aa)
NOB1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (412 aa)
CPSF3Cleavage and polyadenylation specificity factor subunit 3 isoform X3. (684 aa)
RAD1Cell cycle checkpoint protein RAD1 isoform X1. (282 aa)
ZRANB3DNA annealing helicase and endonuclease ZRANB3. (630 aa)
RNASET2Ribonuclease T2; Belongs to the RNase T2 family. (254 aa)
XRN15'-3' exoribonuclease 1. (1695 aa)
EXOSC9Exosome complex component RRP45 isoform X2. (440 aa)
ZNRD1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
PMS2Mismatch repair endonuclease PMS2 isoform X2. (862 aa)
ERI3ERI1 exoribonuclease 3. (278 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2. (620 aa)
DICER1Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1845 aa)
CCDC36Interactor of HORMAD1 protein 1. (414 aa)
DIS3LDIS3-like exonuclease 1 isoform X1; Belongs to the RNR ribonuclease family. (1053 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X2. (915 aa)
UTP23rRNA-processing protein UTP23 homolog isoform X1. (248 aa)
NOL9Polynucleotide 5'-hydroxyl-kinase NOL9. (611 aa)
UBXN8UBX domain-containing protein 8 isoform X1. (247 aa)
BMS1Ribosome biogenesis protein BMS1 homolog. (428 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1061 aa)
ERCC4DNA repair endonuclease XPF isoform X1. (916 aa)
C12orf10LOW QUALITY PROTEIN: UPF0160 protein MYG1, mitochondrial. (348 aa)
N4BP2L1NEDD4-binding protein 2-like 1 isoform X1. (214 aa)
DCLRE1ADNA cross-link repair 1A protein. (576 aa)
TUT1Speckle targeted PIP5K1A-regulated poly(A) polymerase. (911 aa)
PCF11LOW QUALITY PROTEIN: pre-mRNA cleavage complex 2 protein Pcf11. (1677 aa)
POLR3KDNA-directed RNA polymerase III subunit RPC10. (66 aa)
GEN1Flap endonuclease GEN homolog 1. (915 aa)
HORMAD1HORMA domain-containing protein 1 isoform X1. (394 aa)
PARNpoly(A)-specific ribonuclease PARN isoform X1. (65 aa)
KIAA0391Mitochondrial ribonuclease P protein 3 isoform X1. (581 aa)
DCP1AmRNA-decapping enzyme 1A isoform X1. (582 aa)
SAMHD1Deoxynucleoside triphosphate triphosphohydrolase SAMHD1. (583 aa)
RNASEL2-5A-dependent ribonuclease. (738 aa)
FANCMFanconi anemia group M protein. (670 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (918 aa)
N4BP1NEDD4-binding protein 1. (892 aa)
NOCTNocturnin. (314 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (949 aa)
TSEN2tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (461 aa)
ENSTSYP00000021997annotation not available (304 aa)
ENSTSYP00000021999annotation not available (101 aa)
TREX1LOW QUALITY PROTEIN: three-prime repair exonuclease 1. (341 aa)
ENSTSYP00000022043annotation not available (96 aa)
PLD4Phospholipase D4. (535 aa)
ERI13'-5' exoribonuclease 1. (349 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa)
ENSTSYP00000023156annotation not available (245 aa)
POLD1DNA polymerase. (1094 aa)
DDX1ATP-dependent RNA helicase DDX1 isoform X1. (740 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (874 aa)
ZC3H12AEndoribonuclease ZC3H12A isoform X1. (593 aa)
TDP2tyrosyl-DNA phosphodiesterase 2 isoform X3. (309 aa)
PDE122',5'-phosphodiesterase 12 isoform X1. (609 aa)
ERCC2LOW QUALITY PROTEIN: TFIIH basal transcription factor complex helicase XPD subunit. (668 aa)
CNOT1CCR4-NOT transcription complex subunit 1 isoform X1. (2376 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LAS1LRibosomal biogenesis protein LAS1L. (720 aa)
DXODecapping and exoribonuclease protein isoform X2. (396 aa)
DCLRE1B5' exonuclease Apollo. (541 aa)
ZC3H12CProbable ribonuclease ZC3H12C. (874 aa)
INTS11Integrator complex subunit 11 isoform X1. (600 aa)
EME2Probable crossover junction endonuclease EME2. (373 aa)
TSNTranslin isoform X1. (228 aa)
B4GALNT3Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1015 aa)
BOP1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (739 aa)
PNKPBifunctional polynucleotide phosphatase/kinase. (520 aa)
ENSTSYP00000028242annotation not available (638 aa)
ENSTSYP00000028606annotation not available (166 aa)
EXOSC4Exosome complex component RRP41. (245 aa)
NYNRINProtein NYNRIN. (1884 aa)
RAD9ACell cycle checkpoint control protein RAD9A. (388 aa)
LOC103269101Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (301 aa)
ENSTSYP00000029178annotation not available (378 aa)
LOC103276852Schlafen family member 12. (589 aa)
EXOGNuclease EXOG, mitochondrial. (368 aa)
ENSTSYP00000029954annotation not available (68 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (286 aa)
EXOSC2Exosome complex component RRP4 isoform X1. (293 aa)
LOC103255792Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (341 aa)
USB1U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family. (265 aa)
ENSTSYP00000031322annotation not available (213 aa)
LRRC27Leucine-rich repeat-containing protein 27 isoform X1. (532 aa)
KHNYNProtein KHNYN. (672 aa)
APTXAprataxin isoform X4. (342 aa)
DNASE2Deoxyribonuclease-2-alpha isoform X1. (347 aa)
TBL3Transducin beta-like protein 3 isoform X1. (806 aa)
ENSTSYP00000032963annotation not available (104 aa)
YBEYPutative ribonuclease. (167 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
MUS81Crossover junction endonuclease MUS81. (551 aa)
ENSTSYP00000033666annotation not available (184 aa)
HAUS7HAUS augmin-like complex subunit 7. (382 aa)
EXOSC10Exosome component 10. (862 aa)
DROSHARibonuclease 3. (232 aa)
DFFBLOW QUALITY PROTEIN: DNAation factor subunit beta. (296 aa)
CNOT2CCR4-NOT transcription complex subunit 2 isoform X1. (550 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1210 aa)
ENSTSYP00000034469annotation not available (131 aa)
ZC3H12DProbable ribonuclease ZC3H12D. (164 aa)
CNOT7CCR4-NOT transcription complex subunit 7 isoform X1. (285 aa)
ERCC5DNA repair protein complementing XP-G cells. (1612 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
LOC103273533Ribonuclease P protein subunit p21 isoform X1. (154 aa)
LOC103275081DIS3-like exonuclease 2. (124 aa)
CUNH11orf80Type 2 DNA topoisomerase 6 subunit B-like. (539 aa)
LOC103260808Histone-lysine N-methyltransferase SETMAR. (347 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
ENSTSYP00000019247annotation not available (347 aa)
SLFNL1Schlafen like 1. (346 aa)
DNASE1Deoxyribonuclease; Belongs to the DNase I family. (284 aa)
CNOT8CCR4-NOT transcription complex subunit 8 isoform X1. (292 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (743 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (298 aa)
REXO2Oligoribonuclease, mitochondrial isoform X1. (237 aa)
TATDN1Putative deoxyribonuclease TATDN1 isoform X1. (286 aa)
ENSTSYP00000018615annotation not available (270 aa)
ENSTSYP00000018417annotation not available (93 aa)
ANKRD31Putative ankyrin repeat domain-containing protein 31. (1893 aa)
ENSTSYP00000018140annotation not available (110 aa)
REXO4RNA exonuclease 4 isoform X1. (418 aa)
ISG20Interferon-stimulated gene 20 kDa protein isoform X1. (181 aa)
TSEN34tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (308 aa)
MEIOBLOW QUALITY PROTEIN: meiosis-specific with OB domain-containing protein. (470 aa)
HELZ2LOW QUALITY PROTEIN: helicase with zinc finger domain 2. (2534 aa)
CPSF4LCleavage and polyadenylation specific factor 4 like. (158 aa)
RRP36Ribosomal RNA processing protein 36 homolog isoform X1. (255 aa)
ENSTSYP00000016703annotation not available (259 aa)
CPSF4Cleavage and polyadenylation specificity factor subunit 4 isoform X2. (244 aa)
TRIRUncharacterized protein C19orf43 homolog. (157 aa)
MFFMitochondrial fission factor isoform X12. (76 aa)
LOC103268596Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (138 aa)
ISG20L2Interferon-stimulated 20 kDa exonuclease-like 2. (354 aa)
ASTE1Protein asteroid homolog 1. (687 aa)
LOC103256015Ribonuclease 3-like. (134 aa)
RPP40Ribonuclease P protein subunit p40 isoform X1. (363 aa)
SLX1ALOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX1. (62 aa)
EXOSC5Exosome complex component RRP46. (235 aa)
ENSTSYP00000014741annotation not available (102 aa)
TDP1tyrosyl-DNA phosphodiesterase 1-like. (477 aa)
ENSTSYP00000014426annotation not available (130 aa)
POP7Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa)
ENDOUpoly(U)-specific endoribonuclease isoform X1. (412 aa)
POP5Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (169 aa)
ENSTSYP00000014227annotation not available (127 aa)
PIWIL2Piwi-like protein 2; Belongs to the argonaute family. (964 aa)
TATDN3Putative deoxyribonuclease TATDN3 isoform X2. (274 aa)
CPSF1Cleavage and polyadenylation specificity factor subunit 1. (1442 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
ANGEL2Protein angel homolog 2 isoform X1. (544 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1027 aa)
NOP9Nucleolar protein 9. (636 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (855 aa)
RPP30Ribonuclease P protein subunit p30 isoform X1. (288 aa)
DNASE2BDeoxyribonuclease-2-beta. (282 aa)
MEI4Meiosis-specific protein MEI4. (300 aa)
TTC38Tetratricopeptide repeat protein 38. (467 aa)
EXOSC3Exosome complex component RRP40 isoform X1. (275 aa)
AZGP1Zinc-alpha-2-glycoprotein-like; Belongs to the MHC class I family. (303 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (304 aa)
MARF1Meiosis arrest female protein 1 isoform X2. (1738 aa)
LOC103255908Aprataxin and PNK-like factor. (319 aa)
RPP14Ribonuclease P protein subunit p14 isoform X2. (124 aa)
EXOSC8Exosome complex component RRP43. (276 aa)
ABT1Activator of basal transcription 1. (272 aa)
RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (289 aa)
POLGDNA polymerase subunit gamma-1. (1225 aa)
RBBP8DNA endonuclease RBBP8. (896 aa)
WRNLOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1403 aa)
AENApoptosis-enhancing nuclease. (325 aa)
EME1Crossover junction endonuclease EME1. (572 aa)
EXOSC7Exosome complex component RRP42 isoform X1. (291 aa)
ERI2ERI1 exoribonuclease 2. (686 aa)
XPADNA repair protein complementing XP-A cells isoform X1. (273 aa)
NCBP1Nuclear cap-binding protein subunit 1. (423 aa)
ANGEL1Protein angel homolog 1 isoform X2. (667 aa)
AGO3Protein argonaute-3; Belongs to the argonaute family. (724 aa)
DIS3L2DIS3-like exonuclease 2. (544 aa)
KRI1Protein KRI1 homolog. (682 aa)
TOE1Target of EGR1 protein 1 isoform X2. (510 aa)
ZC3H12BProbable ribonuclease ZC3H12B. (836 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (108 aa)
EDC4Enhancer of mRNA-decapping protein 4. (1398 aa)
MGME1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (340 aa)
SWT1Transcriptional protein SWT1. (906 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa)
PLD3Phospholipase D3. (490 aa)
PGBD5piggyBac transposable element-derived protein 5. (423 aa)
PPP1R8Nuclear inhibitor of protein phosphatase 1 isoform X2. (351 aa)
CPSF7Cleavage and polyadenylation specificity factor subunit 7 isoform X1. (471 aa)
ATAD5ATPase family AAA domain-containing protein 5-like. (1204 aa)
ENSTSYP00000008894annotation not available (139 aa)
RCL1RNA 3'-terminal phosphate cyclase-like protein isoform X1. (373 aa)
TATDN2Putative deoxyribonuclease TATDN2. (749 aa)
CNOT6LCCR4-NOT transcription complex subunit 6-like. (550 aa)
CPSF2Cleavage and polyadenylation specificity factor subunit 2. (782 aa)
RAD51CDNA repair protein RAD51 homolog 3. (366 aa)
RPS340S ribosomal protein S3 isoform X1; Belongs to the universal ribosomal protein uS3 family. (280 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6 isoform X2. (588 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
DCP1BmRNA-decapping enzyme 1B isoform X1. (606 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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