28 items (Carlito syrichta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	DDX5	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (601 aa)
	TRUB1	Probable tRNA pseudouridine synthase 1 isoform X1. (351 aa)
	BCDIN3D	pre-miRNA 5'-monophosphate methyltransferase. (293 aa)
	NCOR1	Nuclear receptor corepressor 1 isoform X8. (2437 aa)
	EGFR	Receptor protein-tyrosine kinase. (1180 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
	ENSTSYP00000007785	annotation not available (217 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (671 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	STAT3	Signal transducer and activator of transcription 3. (444 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
	ENSTSYP00000018548	annotation not available (280 aa)
	MYCN	N-myc proto-oncogene protein. (253 aa)
	LIN28B	Protein lin-28 homolog B isoform X1. (258 aa)
	LIN28A	Protein lin-28 homolog A. (209 aa)
	ZC3H10	Zinc finger CCCH domain-containing protein 10. (435 aa)
	ZC3H12A	Endoribonuclease ZC3H12A isoform X1. (593 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	TARBP2	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
	BMP4	Bone morphogenetic protein 4 isoform X1. (409 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
	LOC103256667	Hepatocyte nuclear factor 1-alpha isoform X2. (227 aa)
	IL6	Interleukin-6. (209 aa)
	ENSTSYP00000031894	annotation not available (263 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1078 aa)
	LOC103277171	LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like. (248 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCDIN3D	ZC3H10	ENSTSYP00000001099	ENSTSYP00000023260	pre-miRNA 5'-monophosphate methyltransferase.	Zinc finger CCCH domain-containing protein 10.	0.609
DDX5	ENSTSYP00000018548	ENSTSYP00000027519	ENSTSYP00000018548	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	annotation not available	0.425
DDX5	ESR1	ENSTSYP00000027519	ENSTSYP00000005747	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.951
DDX5	LIN28B	ENSTSYP00000027519	ENSTSYP00000018847	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	Protein lin-28 homolog B isoform X1.	0.425
DDX5	TP53	ENSTSYP00000027519	ENSTSYP00000023752	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.908
DDX5	TRUB1	ENSTSYP00000027519	ENSTSYP00000000410	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	Probable tRNA pseudouridine synthase 1 isoform X1.	0.727
EGFR	ENSTSYP00000031894	ENSTSYP00000005737	ENSTSYP00000031894	Receptor protein-tyrosine kinase.	annotation not available	0.981
EGFR	ESR1	ENSTSYP00000005737	ENSTSYP00000005747	Receptor protein-tyrosine kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.888
EGFR	IL6	ENSTSYP00000005737	ENSTSYP00000031540	Receptor protein-tyrosine kinase.	Interleukin-6.	0.923
EGFR	LOC103277171	ENSTSYP00000005737	ENSTSYP00000033222	Receptor protein-tyrosine kinase.	LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like.	0.952
EGFR	MAP2K1	ENSTSYP00000005737	ENSTSYP00000018336	Receptor protein-tyrosine kinase.	Dual specificity mitogen-activated protein kinase kinase 1.	0.401
EGFR	RIPK1	ENSTSYP00000005737	ENSTSYP00000010281	Receptor protein-tyrosine kinase.	Receptor-interacting serine/threonine-protein kinase 1.	0.547
EGFR	STAT3	ENSTSYP00000005737	ENSTSYP00000011433	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription 3.	0.952
EGFR	TGFB1	ENSTSYP00000005737	ENSTSYP00000030862	Receptor protein-tyrosine kinase.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.579
EGFR	TNF	ENSTSYP00000005737	ENSTSYP00000027201	Receptor protein-tyrosine kinase.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.572
EGFR	TP53	ENSTSYP00000005737	ENSTSYP00000023752	Receptor protein-tyrosine kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.653
ENSTSYP00000018548	DDX5	ENSTSYP00000018548	ENSTSYP00000027519	annotation not available	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	0.425
ENSTSYP00000018548	MYCN	ENSTSYP00000018548	ENSTSYP00000018693	annotation not available	N-myc proto-oncogene protein.	0.454
ENSTSYP00000031894	EGFR	ENSTSYP00000031894	ENSTSYP00000005737	annotation not available	Receptor protein-tyrosine kinase.	0.981
ENSTSYP00000031894	ESR1	ENSTSYP00000031894	ENSTSYP00000005747	annotation not available	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.714