(148 nodes) Secretory granule membrane network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SERPINB12	Serpin B12 isoform X1; Belongs to the serpin family. (425 aa)
	RAB3D	Ras-related protein Rab-3D. (219 aa)
	TOM1	Target of Myb protein 1 isoform X1; Belongs to the TOM1 family. (492 aa)
	SLC44A2	Choline transporter-like protein 2; Belongs to the CTL (choline transporter-like) family. (630 aa)
	DMBT1	Deleted in malignant brain tumors 1 protein. (1855 aa)
	SPACA6	Sperm acrosome membrane-associated protein 6 isoform X1. (325 aa)
	HMOX2	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (316 aa)
	TMEM95	Transmembrane protein 95 isoform X1. (176 aa)
	ACR	Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (378 aa)
	DNAJC5	dnaJ homolog subfamily C member 5 isoform X1. (198 aa)
	CYB561A3	Cytochrome b ascorbate-dependent protein 3. (263 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	RAB37	Ras-related protein Rab-37 isoform X2. (228 aa)
	CD46	Membrane cofactor protein isoform X1. (359 aa)
	LOC103262188	Tetraspanin. (325 aa)
	SYT4	Synaptotagmin-4 isoform X1. (425 aa)
	RAB5C	Ras-related protein Rab-5C isoform X2. (229 aa)
	ICA1	Islet cell autoantigen 1 isoform X1. (523 aa)
	MLEC	Malectin isoform X1. (285 aa)
	LPCAT1	Lysophosphatidylcholine acyltransferase 1. (405 aa)
	TMEM179B	Transmembrane protein 179B. (219 aa)
	TMX3	Protein disulfide-isomerase TMX3 isoform X1. (455 aa)
	DBH	Dopamine beta-hydroxylase. (620 aa)
	SPARC	SPARC isoform X3. (303 aa)
	CD109	CD109 antigen. (1470 aa)
	ITGA2B	Integrin alpha-IIb; Belongs to the integrin alpha chain family. (851 aa)
	ANO6	Anoctamin. (931 aa)
	SERPINB6	Serpin B6; Belongs to the serpin family. (386 aa)
	RAP1A	Ras-related protein Rap-1A. (184 aa)
	SPACA3	LOW QUALITY PROTEIN: sperm acrosome membrane-associated protein 3; Belongs to the glycosyl hydrolase 22 family. (163 aa)
	AGPAT2	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (270 aa)
	DIAPH1	Protein diaphanous homolog 1. (1236 aa)
	CLEC5A	C-type lectin domain family 5 member A isoform X1. (188 aa)
	CKAP4	Cytoskeleton-associated protein 4. (507 aa)
	LOC103249516	Inositol 1,4,5-trisphosphate receptor type 1. (389 aa)
	NRAS	GTPase NRas. (189 aa)
	MANBA	Beta-mannosidase. (820 aa)
	LAMP2	Lysosome-associated membrane glycoprotein 2 isoform X1. (412 aa)
	GLIPR1	Glioma pathogenesis-related protein 1; Belongs to the CRISP family. (266 aa)
	ENSTSYP00000024243	annotation not available (250 aa)
	LOC103272976	Vacuolar protein sorting-associated protein 13B-like. (741 aa)
	IZUMO1	Izumo sperm-egg fusion protein 1. (348 aa)
	TSPAN14	Tetraspanin. (270 aa)
	ABCA3	ATP-binding cassette sub-family A member 3. (1704 aa)
	VAMP7	Vesicle-associated membrane protein 7 isoform X1; Belongs to the synaptobrevin family. (220 aa)
	FRMPD3	FERM and PDZ domain-containing protein 3. (1807 aa)
	ATP11A	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1172 aa)
	VAMP1	Synaptobrevin. (118 aa)
	NFAM1	NFAT activation molecule 1. (262 aa)
	HVCN1	Voltage-gated hydrogen channel 1. (259 aa)
	BST2	Bone marrow stromal antigen 2. (135 aa)
	CLEC12A	C-type lectin domain family 12 member A-like. (272 aa)
	KIF1A	Kinesin-like protein KIF1A isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1787 aa)
	ANPEP	Aminopeptidase. (967 aa)
	PECAM1	Platelet endothelial cell adhesion molecule. (737 aa)
	NBEAL2	Neurobeachin-like protein 2. (2753 aa)
	TMEM184A	Transmembrane protein 184A. (403 aa)
	TARM1	T-cell-interacting, activating receptor on myeloid cells protein 1. (286 aa)
	MCEMP1	Mast cell-expressed membrane protein 1. (191 aa)
	CD59	CD59 glycoprotein isoform X1. (121 aa)
	ENSTSYP00000018913	annotation not available (131 aa)
	DGAT1	O-acyltransferase. (481 aa)
	SYT5	Synaptotagmin-5. (320 aa)
	LAMP3	Lysosome-associated membrane glycoprotein 3. (417 aa)
	CHRNB4	Neuronal acetylcholine receptor subunit beta-4. (493 aa)
	ITGB2	Integrin beta. (769 aa)
	LOC103262500	Tetraspanin. (234 aa)
	LOC103274738	Myeloid cell surface antigen CD33-like isoform X1. (302 aa)
	CD36	Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
	PTPRB	Receptor-type tyrosine-protein phosphatase beta isoform X1. (2216 aa)
	TBC1D10C	Carabin. (261 aa)
	CYSTM1	Cysteine-rich and transmembrane domain-containing protein 1. (96 aa)
	ENSTSYP00000016361	annotation not available (183 aa)
	PCDH7	LOW QUALITY PROTEIN: protocadherin-7. (1003 aa)
	SYT2	Synaptotagmin-2 isoform X1. (419 aa)
	LAIR1	Leukocyte-associated immunoglobulin-like receptor 1. (285 aa)
	SLC30A5	Zinc transporter 5. (764 aa)
	DYNC1LI1	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (474 aa)
	DEGS1	Sphingolipid delta(4)-desaturase DES1. (323 aa)
	SLC11A1	Natural resistance-associated macrophage protein 1 isoform X1. (522 aa)
	TMEM184B	Transmembrane protein 184B isoform X1. (407 aa)
	TMEM190	Transmembrane protein 190. (177 aa)
	SYNGR1	Synaptogyrin. (234 aa)
	ENSTSYP00000013878	annotation not available (169 aa)
	DNAJC13	dnaJ homolog subfamily C member 13 isoform X2. (2243 aa)
	LHFPL2	Lipoma HMGIC fusion partner-like 2 protein isoform X2. (223 aa)
	SCAMP1	Secretory carrier-associated membrane protein. (321 aa)
	TRIP11	Thyroid receptor-interacting protein 11 isoform X1. (1918 aa)
	SLC30A8	Zinc transporter 8. (362 aa)
	CADPS	Calcium-dependent secretion activator 1 isoform X1. (770 aa)
	EQTN	Equatorin. (288 aa)
	SYT1	Synaptotagmin-1 isoform X1. (422 aa)
	SYTL4	Synaptotagmin-like protein 4. (671 aa)
	FAM170B	Protein FAM170B. (284 aa)
	APLP2	Amyloid-like protein 2. (752 aa)
	ITGAM	Integrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
	GP2	Pancreatic secretory granule membrane major glycoprotein GP2 isoform X1. (555 aa)
	PAM	Peptidyl-glycine alpha-amidating monooxygenase isoform X1. (983 aa)
	ZG16	Zymogen granule membrane protein 16. (167 aa)
	ITGAX	Integrin alpha-X; Belongs to the integrin alpha chain family. (1149 aa)
	ENPP4	Bis(5'-adenosyl)-triphosphatase ENPP4. (453 aa)
	RAB27B	Ras-related protein Rab-27B. (218 aa)
	CUZD1	CUB and zona pellucida-like domain-containing protein 1. (607 aa)
	MS4A3	LOW QUALITY PROTEIN: membrane-spanning 4-domains subfamily A member 3. (213 aa)
	PHACTR2	Phosphatase and actin regulator. (636 aa)
	ENSTSYP00000008358	annotation not available (318 aa)
	ABCA12	ATP-binding cassette sub-family A member 12. (2595 aa)
	CD177	CD177 antigen. (428 aa)
	CD53	Tetraspanin. (219 aa)
	TEKT3	Tektin-3. (490 aa)
	SLCO4C1	Solute carrier organic anion transporter family member. (722 aa)
	ADGRG3	Adhesion G protein-coupled receptor G3; Belongs to the G-protein coupled receptor 2 family. (430 aa)
	VNN1	Pantetheinase. (514 aa)
	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B. (462 aa)
	LOC103255107	Microsomal glutathione S-transferase 1. (155 aa)
	CD93	Complement component C1q receptor. (648 aa)
	ATP11B	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1161 aa)
	STK10	Serine/threonine-protein kinase 10. (901 aa)
	HGSNAT	LOW QUALITY PROTEIN: heparan-alpha-glucosaminide N-acetyltransferase. (295 aa)
	IGF2R	Cation-independent mannose-6-phosphate receptor. (2180 aa)
	ABCC4	Multidrug resistance-associated protein 4. (845 aa)
	OLR1	Oxidized low-density lipoprotein receptor 1-like. (274 aa)
	UBR4	E3 ubiquitin-protein ligase UBR4 isoform X1. (5192 aa)
	STXBP5	Syntaxin-binding protein 5 isoform X1. (1150 aa)
	NFASC	Neurofascin isoform X1. (1346 aa)
	CD68	Macrosialin isoform X1. (357 aa)
	ATP8B4	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1023 aa)
	PKP1	Plakophilin-1. (740 aa)
	CCDC136	Coiled-coil domain-containing protein 136. (1152 aa)
	BST1	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2. (297 aa)
	PTPRJ	Receptor-type tyrosine-protein phosphatase eta. (1260 aa)
	SURF4	Surfeit locus protein 4 isoform X1. (269 aa)
	STOM	Erythrocyte band 7 integral membrane protein. (289 aa)
	CYB5R1	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
	ABCA13	ATP-binding cassette sub-family A member 13. (3282 aa)
	LOC103261480	Carcinoembryonic antigen-related cell adhesion molecule 1-like isoform X2. (524 aa)
	MGAM	Maltase-glucoamylase, intestinal. (2703 aa)
	VPS13B	Vacuolar protein sorting-associated protein 13B. (2347 aa)
	PRCP	Lysosomal Pro-X carboxypeptidase. (440 aa)
	TMEM225	Transmembrane protein 225. (222 aa)
	SPACA1	Sperm acrosome membrane-associated protein 1. (225 aa)
	SERPINB10	Serpin B10; Belongs to the serpin family. (397 aa)
	ATP8A1	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1147 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C. (601 aa)
	SELP	P-selectin. (830 aa)
	LY6G6F	Lymphocyte antigen 6 complex locus protein G6f. (299 aa)
	B4GALT1	Beta-1,4-galactosyltransferase 1. (398 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2 isoform X1. (1573 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA12	ABCC4	ENSTSYP00000008018	ENSTSYP00000005234	ATP-binding cassette sub-family A member 12.	Multidrug resistance-associated protein 4.	0.569
ABCA13	ABCA3	ENSTSYP00000002847	ENSTSYP00000023506	ATP-binding cassette sub-family A member 13.	ATP-binding cassette sub-family A member 3.	0.447
ABCA13	ABCC4	ENSTSYP00000002847	ENSTSYP00000005234	ATP-binding cassette sub-family A member 13.	Multidrug resistance-associated protein 4.	0.518
ABCA3	ABCA13	ENSTSYP00000023506	ENSTSYP00000002847	ATP-binding cassette sub-family A member 3.	ATP-binding cassette sub-family A member 13.	0.447
ABCA3	ABCC4	ENSTSYP00000023506	ENSTSYP00000005234	ATP-binding cassette sub-family A member 3.	Multidrug resistance-associated protein 4.	0.551
ABCA3	LAMP3	ENSTSYP00000023506	ENSTSYP00000017920	ATP-binding cassette sub-family A member 3.	Lysosome-associated membrane glycoprotein 3.	0.405
ABCA3	LPCAT1	ENSTSYP00000023506	ENSTSYP00000030153	ATP-binding cassette sub-family A member 3.	Lysophosphatidylcholine acyltransferase 1.	0.490
ABCC4	ABCA12	ENSTSYP00000005234	ENSTSYP00000008018	Multidrug resistance-associated protein 4.	ATP-binding cassette sub-family A member 12.	0.569
ABCC4	ABCA13	ENSTSYP00000005234	ENSTSYP00000002847	Multidrug resistance-associated protein 4.	ATP-binding cassette sub-family A member 13.	0.518
ABCC4	ABCA3	ENSTSYP00000005234	ENSTSYP00000023506	Multidrug resistance-associated protein 4.	ATP-binding cassette sub-family A member 3.	0.551
ABCC4	ATP11A	ENSTSYP00000005234	ENSTSYP00000023124	Multidrug resistance-associated protein 4.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.460
ABCC4	CUZD1	ENSTSYP00000005234	ENSTSYP00000009147	Multidrug resistance-associated protein 4.	CUB and zona pellucida-like domain-containing protein 1.	0.410
ABCC4	DGAT1	ENSTSYP00000005234	ENSTSYP00000018534	Multidrug resistance-associated protein 4.	O-acyltransferase.	0.405
ABCC4	LOC103249516	ENSTSYP00000005234	ENSTSYP00000024997	Multidrug resistance-associated protein 4.	Inositol 1,4,5-trisphosphate receptor type 1.	0.405
ABCC4	VAMP1	ENSTSYP00000005234	ENSTSYP00000022975	Multidrug resistance-associated protein 4.	Synaptobrevin.	0.436
ABCC4	VAMP7	ENSTSYP00000005234	ENSTSYP00000023496	Multidrug resistance-associated protein 4.	Vesicle-associated membrane protein 7 isoform X1; Belongs to the synaptobrevin family.	0.455
ACR	APLP2	ENSTSYP00000032523	ENSTSYP00000011395	Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.	Amyloid-like protein 2.	0.543
ACR	CD109	ENSTSYP00000032523	ENSTSYP00000029286	Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.	CD109 antigen.	0.489
ACR	ENSTSYP00000016361	ENSTSYP00000032523	ENSTSYP00000016361	Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.	annotation not available	0.445
ACR	IZUMO1	ENSTSYP00000032523	ENSTSYP00000024103	Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.	Izumo sperm-egg fusion protein 1.	0.692