(55 nodes) Plasma membrane raft network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SORBS1	Sorbin and SH3 domain-containing protein 1 isoform X1. (1292 aa)
	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2. (2527 aa)
	HDAC6	Histone deacetylase 6. (1213 aa)
	PTCH1	Protein patched homolog 1. (1318 aa)
	STOM	Erythrocyte band 7 integral membrane protein. (289 aa)
	CDH13	Cadherin-13. (346 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	PLPP1	Phospholipid phosphatase 1. (287 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	SKAP1	Src kinase-associated phosphoprotein 1. (300 aa)
	CD177	CD177 antigen. (428 aa)
	CORO1C	Coronin; Belongs to the WD repeat coronin family. (496 aa)
	LRP4	Low-density lipoprotein receptor-related protein 4. (1912 aa)
	LOC103276767	Membrane-spanning 4-domains subfamily A member 4A-like. (171 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2018 aa)
	ITGAM	Integrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
	MS4A1	B-lymphocyte antigen CD20. (294 aa)
	ADCY8	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (931 aa)
	DLC1	Rho GTPase-activating protein 7 isoform X1. (1528 aa)
	SELE	E-selectin. (611 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	CD36	Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (467 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	ITGB2	Integrin beta. (769 aa)
	SELPLG	P-selectin glycoprotein ligand 1. (375 aa)
	MLC1	Membrane protein MLC1 isoform X2. (377 aa)
	LRP8	Low-density lipoprotein receptor-related protein 8 isoform X1. (936 aa)
	RANGRF	Ran guanine nucleotide release factor isoform X1. (186 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1140 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (443 aa)
	PTGIS	Prostacyclin synthase. (496 aa)
	LOC103265705	Myoferlin. (1294 aa)
	ORAI1	Calcium release-activated calcium channel protein 1 isoform X2. (237 aa)
	LOC103277142	Myoferlin-like. (417 aa)
	STIM1	Stromal interaction molecule 1 isoform X1. (792 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
	ENSTSYP00000026316	annotation not available (161 aa)
	ADTRP	Androgen-dependent TFPI-regulating protein. (251 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (471 aa)
	MAPK3	Mitogen-activated protein kinase. (363 aa)
	PLVAP	Plasmalemma vesicle-associated protein. (393 aa)
	CAVIN3	Protein kinase C delta-binding protein isoform X2. (282 aa)
	CLN3	Battenin. (438 aa)
	CBL	E3 ubiquitin-protein ligase CBL. (898 aa)
	LOC103268676	Cadherin-1-like. (413 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	EZR	Ezrin isoform X3. (598 aa)
	EHD2	EH domain-containing protein 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (375 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	ASAH2	Neutral ceramidase. (768 aa)
	ENSTSYP00000033676	annotation not available (300 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	CAVIN2	Serum deprivation-response protein. (428 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASAH2	PLPP1	ENSTSYP00000033408	ENSTSYP00000006780	Neutral ceramidase.	Phospholipid phosphatase 1.	0.845
ATP2B4	NOS3	ENSTSYP00000019145	ENSTSYP00000026080	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Nitric oxide synthase; Produces nitric oxide (NO).	0.735
ATP2B4	SCN5A	ENSTSYP00000019145	ENSTSYP00000010476	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.525
CAV1	CAV2	ENSTSYP00000032202	ENSTSYP00000007329	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.991
CAV1	CAV3	ENSTSYP00000032202	ENSTSYP00000033760	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.866
CAV1	CAVIN2	ENSTSYP00000032202	ENSTSYP00000033906	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Serum deprivation-response protein.	0.569
CAV1	CAVIN3	ENSTSYP00000032202	ENSTSYP00000029760	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Protein kinase C delta-binding protein isoform X2.	0.568
CAV1	EHD2	ENSTSYP00000032202	ENSTSYP00000032917	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	EH domain-containing protein 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.406
CAV1	FLOT1	ENSTSYP00000032202	ENSTSYP00000017539	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.709
CAV1	FLOT2	ENSTSYP00000032202	ENSTSYP00000027407	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.695
CAV1	ITGB2	ENSTSYP00000032202	ENSTSYP00000017575	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta.	0.686
CAV1	LOC103265705	ENSTSYP00000032202	ENSTSYP00000021874	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myoferlin.	0.486
CAV1	LOC103277142	ENSTSYP00000032202	ENSTSYP00000025402	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myoferlin-like.	0.486
CAV1	LRP4	ENSTSYP00000032202	ENSTSYP00000009906	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Low-density lipoprotein receptor-related protein 4.	0.511
CAV1	LRP8	ENSTSYP00000032202	ENSTSYP00000018934	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Low-density lipoprotein receptor-related protein 8 isoform X1.	0.464
CAV1	NOS3	ENSTSYP00000032202	ENSTSYP00000026080	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Nitric oxide synthase; Produces nitric oxide (NO).	0.920
CAV1	SRC	ENSTSYP00000032202	ENSTSYP00000033233	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.902
CAV1	STOM	ENSTSYP00000032202	ENSTSYP00000003115	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Erythrocyte band 7 integral membrane protein.	0.499
CAV2	CAV1	ENSTSYP00000007329	ENSTSYP00000032202	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.991
CAV2	CAV3	ENSTSYP00000007329	ENSTSYP00000033760	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.992