(21 nodes) EGF-like, conserved site network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOTCH1	Neurogenic locus notch homolog protein 1. (2339 aa)
	MEGF10	Multiple epidermal growth factor-like domains protein 10. (1138 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1. (2970 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	SNED1	Sushi, nidogen and EGF-like domain-containing protein 1. (596 aa)
	CRB1	Protein crumbs homolog 1. (674 aa)
	NOTCH3	Neurogenic locus notch homolog protein 3. (2169 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2. (2211 aa)
	SLIT3	Slit homolog 3 protein. (1491 aa)
	SLIT2	Slit homolog 2 protein isoform X1. (1542 aa)
	MEGF11	Multiple epidermal growth factor-like domains protein 11. (1122 aa)
	LTBP2	Latent-transforming growth factor beta-binding protein 2. (1622 aa)
	SLIT1	LOW QUALITY PROTEIN: slit homolog 1 protein-like. (1014 aa)
	DLK1	Protein delta homolog 1. (390 aa)
	LTBP4	Latent-transforming growth factor beta-binding protein 4. (1507 aa)
	WIF1	Wnt inhibitory factor 1. (452 aa)
	FBN2	Fibrillin-2. (2912 aa)
	NOTCH4	Neurogenic locus notch homolog protein 4. (1999 aa)
	LOC103274258	Delta and Notch-like epidermal growth factor-related receptor. (372 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1101 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRB1	NOTCH1	ENSTSYP00000011176	ENSTSYP00000033056	Protein crumbs homolog 1.	Neurogenic locus notch homolog protein 1.	0.595
CRB1	NOTCH4	ENSTSYP00000011176	ENSTSYP00000034218	Protein crumbs homolog 1.	Neurogenic locus notch homolog protein 4.	0.465
DLK1	NOTCH1	ENSTSYP00000019513	ENSTSYP00000033056	Protein delta homolog 1.	Neurogenic locus notch homolog protein 1.	0.718
DLK1	NOTCH2	ENSTSYP00000019513	ENSTSYP00000011674	Protein delta homolog 1.	Neurogenic locus notch homolog protein 2.	0.535
DLK1	NOTCH3	ENSTSYP00000019513	ENSTSYP00000011625	Protein delta homolog 1.	Neurogenic locus notch homolog protein 3.	0.409
DLL1	JAG1	ENSTSYP00000005404	ENSTSYP00000002804	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.668
DLL1	JAG2	ENSTSYP00000005404	ENSTSYP00000032111	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.551
DLL1	NOTCH1	ENSTSYP00000005404	ENSTSYP00000033056	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1.	0.988
DLL1	NOTCH2	ENSTSYP00000005404	ENSTSYP00000011674	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 2.	0.963
DLL1	NOTCH3	ENSTSYP00000005404	ENSTSYP00000011625	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 3.	0.947
DLL1	NOTCH4	ENSTSYP00000005404	ENSTSYP00000034218	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 4.	0.934
FBN2	NOTCH1	ENSTSYP00000031618	ENSTSYP00000033056	Fibrillin-2.	Neurogenic locus notch homolog protein 1.	0.595
FBN2	NOTCH4	ENSTSYP00000031618	ENSTSYP00000034218	Fibrillin-2.	Neurogenic locus notch homolog protein 4.	0.465
JAG1	DLL1	ENSTSYP00000002804	ENSTSYP00000005404	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.668
JAG1	JAG2	ENSTSYP00000002804	ENSTSYP00000032111	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.909
JAG1	NOTCH1	ENSTSYP00000002804	ENSTSYP00000033056	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1.	0.994
JAG1	NOTCH2	ENSTSYP00000002804	ENSTSYP00000011674	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 2.	0.973
JAG1	NOTCH3	ENSTSYP00000002804	ENSTSYP00000011625	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 3.	0.950
JAG1	NOTCH4	ENSTSYP00000002804	ENSTSYP00000034218	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 4.	0.932
JAG2	DLL1	ENSTSYP00000032111	ENSTSYP00000005404	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.551