STRINGSTRING
PRKCD PRKCD ERBB4 ERBB4 BTC BTC SOS1 SOS1 HRAS HRAS PRKCA PRKCA KRAS KRAS PTPN12 PTPN12 NRG3 NRG3 EGFR EGFR EREG EREG NRG4 NRG4 NRG2 NRG2 GRB2 GRB2 NRG1 NRG1 NRAS NRAS LOC103275563 LOC103275563 ERBB2 ERBB2 HBEGF HBEGF SHC1 SHC1 EGF EGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
BTCProbetacellulin. (178 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
HRASGTPase HRas isoform X6. (189 aa)
PRKCAProtein kinase C. (614 aa)
KRASGTPase KRas isoform X1. (189 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (663 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X2. (344 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
EREGProepiregulin. (167 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (243 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
NRASGTPase NRas. (189 aa)
LOC103275563Receptor tyrosine-protein kinase erbB-3. (169 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
SHC1SHC-transforming protein 1 isoform X1. (474 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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