STRINGSTRING
ENSTSYP00000024219 ENSTSYP00000024219 ATM ATM AKT3 AKT3 PRDM1 PRDM1 CCNG1 CCNG1 MTOR MTOR PPP2CB PPP2CB PHF20 PHF20 PPP2CA PPP2CA ENSTSYP00000014559 ENSTSYP00000014559 CCNA1 CCNA1 CCNA2 CCNA2 CDK2 CDK2 LOC110596262 LOC110596262 AKT2 AKT2 CDK3 CDK3 PRR5 PRR5 RNF34 RNF34 PDPK1 PDPK1 CHEK2 CHEK2 TXNDC11 TXNDC11 MAPKAP1 MAPKAP1 AKT1 AKT1 ENSTSYP00000030676 ENSTSYP00000030676 USP2 USP2 MLST8 MLST8 ENSTSYP00000027147 ENSTSYP00000027147 PPP2R5C PPP2R5C RPS27A RPS27A DAXX DAXX PPP2R1B PPP2R1B USP7 USP7 PPP2R1A PPP2R1A ENSTSYP00000017997 ENSTSYP00000017997 SGK1 SGK1 ENSTSYP00000019212 ENSTSYP00000019212 CDK1 CDK1 RFFL RFFL MDM4 MDM4 ENSTSYP00000022222 ENSTSYP00000022222 LOC103250373 LOC103250373 TP53 TP53 RICTOR RICTOR UBA52 UBA52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSTSYP00000024219annotation not available (592 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
PRDM1PR domain zinc finger protein 1. (825 aa)
CCNG1cyclin-G1 isoform X1; Belongs to the cyclin family. (295 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PHF20PHD finger protein 20. (1011 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ENSTSYP00000014559annotation not available (115 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (455 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (430 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
LOC110596262ubiquitin-40S ribosomal protein S27a-like. (156 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CDK3Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (305 aa)
PRR5Proline-rich protein 5 isoform X1. (388 aa)
RNF34E3 ubiquitin-protein ligase RNF34 isoform X1. (494 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (554 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (582 aa)
TXNDC11Thioredoxin domain-containing protein 11 isoform X1. (957 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (522 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
ENSTSYP00000030676annotation not available (108 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X2. (326 aa)
ENSTSYP00000027147annotation not available (149 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (556 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
DAXXDeath domain-associated protein 6 isoform X2. (732 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3. (667 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family. (1117 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (589 aa)
ENSTSYP00000017997annotation not available (123 aa)
SGK1Non-specific serine/threonine protein kinase. (527 aa)
ENSTSYP00000019212annotation not available (259 aa)
CDK1Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (297 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X1. (363 aa)
MDM4Protein Mdm4 isoform X1. (491 aa)
ENSTSYP00000022222annotation not available (155 aa)
LOC103250373E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (426 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1699 aa)
UBA52ubiquitin-60S ribosomal protein L40 isoform X1. (231 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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