STRINGSTRING
FAM102A FAM102A FGF16 FGF16 STRN3 STRN3 MET MET BTC BTC IRAK4 IRAK4 CD19 CD19 PTPN11 PTPN11 PIP5K1B-2 PIP5K1B-2 ICOS ICOS PIK3CA PIK3CA KIT KIT PPP4R4 PPP4R4 PDGFRA PDGFRA NRG4 NRG4 PIP5K1A PIP5K1A EREG EREG FNDC3A FNDC3A IL1RL1 IL1RL1 CD80 CD80 EGFR EGFR ESR1 ESR1 RELCH RELCH KLB KLB LOC103271002 LOC103271002 NRG3 NRG3 GAB1 GAB1 ENSTSYP00000006680 ENSTSYP00000006680 FNDC3B FNDC3B ERBB4 ERBB4 MYD88 MYD88 IL33 IL33 EGF EGF AREG AREG FGFR2 FGFR2 PPP4R1 PPP4R1 LOC103251683 LOC103251683 STRN STRN SPEM1 SPEM1 FLT3 FLT3 HBEGF HBEGF HGF HGF FNBP4 FNBP4 PPP2CB PPP2CB LOC103266246 LOC103266246 FGF5 FGF5 PIP4K2A PIP4K2A FYN FYN PPP2CA PPP2CA ERBB2 ERBB2 FGF6 FGF6 TRAT1 TRAT1 CD28 CD28 FGF3 FGF3 FGF7 FGF7 PPP2R5E PPP2R5E TRAF6 TRAF6 PIP4K2C PIP4K2C PPP2R1B PPP2R1B FRS2 FRS2 PPP2R1A PPP2R1A RHOG RHOG ESR2 ESR2 PPP2R5B PPP2R5B FGF1 FGF1 WDR64 WDR64 GAB2 GAB2 ENSTSYP00000019212 ENSTSYP00000019212 LOC103267910 LOC103267910 ENSTSYP00000019960 ENSTSYP00000019960 PIP5K1C PIP5K1C FGF20 FGF20 FGF20-2 FGF20-2 FGF17 FGF17 PIK3R1 PIK3R1 STRN4 STRN4 FGF10 FGF10 TGFA TGFA LCK LCK FGF9 FGF9 PPP2R5D PPP2R5D FGFR1 FGFR1 PIP5KL1 PIP5KL1 ENSTSYP00000022643 ENSTSYP00000022643 KITLG KITLG INSR INSR CUNH17orf74 CUNH17orf74 IL1RAP IL1RAP ENSTSYP00000024219 ENSTSYP00000024219 PPP2R5A PPP2R5A LOC103275563 LOC103275563 PIP5K1B PIP5K1B FGFR3 FGFR3 PIK3R3 PIK3R3 LOC103254497 LOC103254497 KL KL FGF18 FGF18 NRG1 NRG1 MAPK3 MAPK3 ENSTSYP00000027924 ENSTSYP00000027924 CD86 CD86 PPP2R5C PPP2R5C IER3 IER3 PIK3AP1 PIK3AP1 PDGFRB PDGFRB FAM102B FAM102B PDGFB PDGFB INSC INSC PIK3CD PIK3CD EPGN EPGN AKT1 AKT1 IRAK1 IRAK1 LOC103271944 LOC103271944 MAPK1 MAPK1 GRAP GRAP GRB2 GRB2 ENSTSYP00000033115 ENSTSYP00000033115 PIP4K2B PIP4K2B SRC SRC PDGFA PDGFA NRG2 NRG2 FLT3LG FLT3LG PIK3CB PIK3CB CD276 CD276
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAM102AProtein FAM102A. (385 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
STRN3Striatin-3 isoform X1. (797 aa)
METHepatocyte growth factor receptor isoform X1. (1415 aa)
BTCProbetacellulin. (178 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (556 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (532 aa)
PIP5K1B-2Phosphatidylinositol 4-phosphate 5-kinase type-1 beta. (257 aa)
ICOSInducible T-cell costimulator. (202 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KITMast/stem cell growth factor receptor Kit; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X7. (809 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2. (581 aa)
EREGProepiregulin. (167 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1196 aa)
IL1RL1Interleukin-1 receptor-like 1. (429 aa)
CD80T-lymphocyte activation antigen CD80. (232 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (721 aa)
KLBBeta-klotho. (835 aa)
LOC103271002Receptor tyrosine-protein kinase erbB-3. (580 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X2. (344 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (700 aa)
ENSTSYP00000006680annotation not available (255 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1203 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
IL33Interleukin-33-like. (231 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
AREGAmphiregulin isoform X1. (270 aa)
FGFR2Fibroblast growth factor receptor 2 isoform X1. (615 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (803 aa)
LOC103251683Insulin-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (99 aa)
STRNStriatin isoform X1. (780 aa)
SPEM1Spermatid maturation protein 1. (310 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (980 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
FNBP4Formin-binding protein 4 isoform X2. (669 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LOC103266246WD repeat-containing protein 64-like. (276 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (386 aa)
FYNTyrosine-protein kinase. (537 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TRAT1T-cell receptor-associated transmembrane adapter 1. (187 aa)
CD28T-cell-specific surface glycoprotein CD28 isoform X2. (221 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (512 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1. (421 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3. (667 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (589 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
ESR2Estrogen receptor beta isoform X1. (530 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (365 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
WDR64WD repeat-containing protein 64. (359 aa)
GAB2GRB2-associated-binding protein 2. (651 aa)
ENSTSYP00000019212annotation not available (259 aa)
LOC103267910Fibroblast growth factor receptor 2-like. (208 aa)
ENSTSYP00000019960annotation not available (172 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (698 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
FGF20-2Fibroblast growth factor 20. (75 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
STRN4Striatin-4 isoform X1. (760 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TGFATransforming growth factor alpha. (164 aa)
LCKTyrosine-protein kinase. (524 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
FGFR1Fibroblast growth factor receptor. (832 aa)
PIP5KL1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. (177 aa)
ENSTSYP00000022643annotation not available (512 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
INSRTyrosine-protein kinase receptor. (1356 aa)
CUNH17orf74Uncharacterized protein C17orf74 homolog. (486 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform X1. (687 aa)
ENSTSYP00000024219annotation not available (592 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (475 aa)
LOC103275563Receptor tyrosine-protein kinase erbB-3. (169 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta-like. (283 aa)
FGFR3Fibroblast growth factor receptor. (745 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
LOC103254497lisH domain and HEAT repeat-containing protein KIAA1468-like. (391 aa)
KLKlotho; Belongs to the glycosyl hydrolase 1 family. (972 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
ENSTSYP00000027924annotation not available (51 aa)
CD86T-lymphocyte activation antigen CD86. (273 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (556 aa)
IER3Radiation-inducible immediate-early gene IEX-1. (156 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1. (849 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
FAM102BProtein FAM102B. (360 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
INSCProtein inscuteable homolog isoform X1. (579 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
EPGNEpigen isoform X1. (153 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (618 aa)
LOC103271944Proto-oncogene vav. (147 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
GRAPGRB2-related adapter protein. (188 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
ENSTSYP00000033115annotation not available (96 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (363 aa)
SRCTyrosine-protein kinase. (542 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (243 aa)
FLT3LGFms-related tyrosine kinase 3 ligand. (237 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
CD276CD276 antigen. (315 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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