STRINGSTRING
POLD1 POLD1 ENSTSYP00000000614 ENSTSYP00000000614 PSMA5 PSMA5 RPS27A RPS27A DNA2 DNA2 ANAPC4 ANAPC4 PSMB1 PSMB1 MCM7 MCM7 CDC27 CDC27 GINS1 GINS1 CCNA2 CCNA2 MCM6 MCM6 UBE2D1 UBE2D1 RPA1 RPA1 PSMA1 PSMA1 PSMD2 PSMD2 POLE2 POLE2 MCM8 MCM8 PSMD14 PSMD14 ANAPC7 ANAPC7 CCNE1 CCNE1 PSMA4 PSMA4 GINS4 GINS4 PSMF1 PSMF1 PSME1 PSME1 PSMB2 PSMB2 POLA1 POLA1 CCNA1 CCNA1 TM4SF19 TM4SF19 MCM2 MCM2 PSMA8 PSMA8 PRIM1 PRIM1 ORC3 ORC3 POLD3 POLD3 ORC4 ORC4 CDC6 CDC6 PSMB9 PSMB9 PSMC1 PSMC1 PSMB4 PSMB4 LOC103272535 LOC103272535 CDC23 CDC23 RFC3 RFC3 ATAD5 ATAD5 PSMC6 PSMC6 RCBTB1 RCBTB1 ORC2 ORC2 POLE POLE ENSTSYP00000009770 ENSTSYP00000009770 SKP1 SKP1 PSMD5 PSMD5 PSMA7 PSMA7 POLD2 POLD2 GMNN GMNN PSMD6 PSMD6 PSME4 PSME4 PSMD11 PSMD11 PSMB7 PSMB7 PSMD3 PSMD3 ANAPC5 ANAPC5 ORC5 ORC5 PSMB3 PSMB3 PSMD1 PSMD1 PSMD12 PSMD12 ORC1 ORC1 TM7SF3 TM7SF3 RFC1 RFC1 ANAPC15 ANAPC15 POLE4 POLE4 MCM5 MCM5 PSMA6 PSMA6 ENSTSYP00000014559 ENSTSYP00000014559 RFC5 RFC5 ENSTSYP00000015668 ENSTSYP00000015668 CDK3 CDK3 POLE3 POLE3 PSMC3 PSMC3 CUL1 CUL1 ORC6 ORC6 UBE2S UBE2S ENSTSYP00000017183 ENSTSYP00000017183 CDC45 CDC45 LOC103265662 LOC103265662 ANAPC1 ANAPC1 CDC16 CDC16 LOC103268591 LOC103268591 RFC4 RFC4 MEIOB MEIOB ENSTSYP00000017997 ENSTSYP00000017997 UBE2E1 UBE2E1 CDT1 CDT1 ENSTSYP00000019039 ENSTSYP00000019039 PCNA PCNA ENSTSYP00000019195 ENSTSYP00000019195 ENSTSYP00000019245 ENSTSYP00000019245 PSMD10 PSMD10 RBX1 RBX1 PSMB6 PSMB6 CDC26 CDC26 SKP2 SKP2 ENSTSYP00000021013 ENSTSYP00000021013 PSME3 PSME3 ENSTSYP00000021540 ENSTSYP00000021540 GINS2 GINS2 MCM3 MCM3 ENSTSYP00000022222 ENSTSYP00000022222 CCNE2 CCNE2 ENSTSYP00000023689 ENSTSYP00000023689 ANAPC11 ANAPC11 GINS3 GINS3 UBA52 UBA52 ENSTSYP00000024485 ENSTSYP00000024485 LIG1 LIG1 ENSTSYP00000024947 ENSTSYP00000024947 ENSTSYP00000024958 ENSTSYP00000024958 ENSTSYP00000025346 ENSTSYP00000025346 PSMD4 PSMD4 PSMD9 PSMD9 FEN1 FEN1 ENSTSYP00000025727 ENSTSYP00000025727 PSMD13 PSMD13 PRIM2 PRIM2 ANAPC10 ANAPC10 PSMB10 PSMB10 ENSTSYP00000026533 ENSTSYP00000026533 LOC103272490 LOC103272490 ENSTSYP00000027147 ENSTSYP00000027147 ANAPC16 ANAPC16 ENSTSYP00000027311 ENSTSYP00000027311 PSMC5 PSMC5 ENSTSYP00000027888 ENSTSYP00000027888 ENSTSYP00000028373 ENSTSYP00000028373 ENSTSYP00000028450 ENSTSYP00000028450 ENSTSYP00000028770 ENSTSYP00000028770 FZR1 FZR1 LOC103250392 LOC103250392 ANAPC2 ANAPC2 ENSTSYP00000030504 ENSTSYP00000030504 UBE2C UBE2C ENSTSYP00000030676 ENSTSYP00000030676 PSMB8 PSMB8 LOC103262238 LOC103262238 ENSTSYP00000031072 ENSTSYP00000031072 POLD4 POLD4 RPA3 RPA3 ENSTSYP00000031721 ENSTSYP00000031721 PSMA2 PSMA2 PSMB5 PSMB5 ENSTSYP00000032262 ENSTSYP00000032262 PSME2 PSME2 ENSTSYP00000032718 ENSTSYP00000032718 RFC2 RFC2 PSMC4 PSMC4 ENSTSYP00000033058 ENSTSYP00000033058 PSMA3 PSMA3 LOC110596262 LOC110596262 CDK2 CDK2 ENSTSYP00000034042 ENSTSYP00000034042 MCM4 MCM4 ENSTSYP00000034634 ENSTSYP00000034634 RCBTB2 RCBTB2 PSMD8 PSMD8 MCM9 MCM9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLD1DNA polymerase. (1094 aa)
ENSTSYP00000000614annotation not available (191 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1061 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
PSMB1Proteasome subunit beta. (241 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (714 aa)
CDC27Cell division cycle protein 27 homolog isoform X1. (828 aa)
GINS1DNA replication complex GINS protein PSF1 isoform X1. (196 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (430 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
PSMA1Proteasome subunit alpha type. (264 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
POLE2DNA polymerase epsilon subunit 2. (527 aa)
MCM8DNA helicase MCM8; Belongs to the MCM family. (832 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (326 aa)
ANAPC7Anaphase-promoting complex subunit 7. (588 aa)
CCNE1G1/S-specific cyclin-E1. (410 aa)
PSMA4Proteasome subunit alpha type. (179 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
PSMF1Proteasome inhibitor PI31 subunit isoform X2. (272 aa)
PSME1Proteasome activator complex subunit 1 isoform X1. (250 aa)
PSMB2Proteasome subunit beta. (201 aa)
POLA1DNA polymerase alpha catalytic subunit. (988 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (455 aa)
TM4SF19Transmembrane 4 L6 family member 19 isoform X2. (209 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (417 aa)
ORC3Origin recognition complex subunit 3 isoform X2. (711 aa)
POLD3DNA polymerase delta subunit 3 isoform X2. (425 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (435 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
LOC10327253526S proteasome non-ATPase regulatory subunit 7. (324 aa)
CDC23Cell division cycle protein 23 homolog. (597 aa)
RFC3Replication factor C subunit 3 isoform X1. (270 aa)
ATAD5ATPase family AAA domain-containing protein 5-like. (1204 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (391 aa)
ORC2Origin recognition complex subunit 2 isoform X1. (574 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa)
ENSTSYP00000009770annotation not available (227 aa)
SKP1S-phase kinase-associated protein 1 isoform X2; Belongs to the SKP1 family. (163 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5 isoform X1. (513 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
GMNNGeminin isoform X1. (203 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6 isoform X1. (416 aa)
PSME4Proteasome activator complex subunit 4 isoform X2. (1825 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3 isoform X2. (534 aa)
ANAPC5Anaphase-promoting complex subunit 5. (613 aa)
ORC5Origin recognition complex subunit 5. (309 aa)
PSMB3Proteasome subunit beta. (207 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (623 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (420 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
RFC1Replication factor C subunit 1. (1147 aa)
ANAPC15Anaphase-promoting complex subunit 15 isoform X2. (121 aa)
POLE4DNA polymerase epsilon subunit 4. (117 aa)
MCM5DNA replication licensing factor MCM5; Belongs to the MCM family. (598 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
ENSTSYP00000014559annotation not available (115 aa)
RFC5Replication factor C subunit 5 isoform X1. (339 aa)
ENSTSYP00000015668annotation not available (251 aa)
CDK3Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (305 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (450 aa)
CUL1Cullin-1 isoform X1; Belongs to the cullin family. (776 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
UBE2SUbiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (77 aa)
ENSTSYP00000017183annotation not available (581 aa)
CDC45Cell division control protein 45 homolog isoform X1. (600 aa)
LOC103265662DNA polymerase alpha subunit B. (391 aa)
ANAPC1Anaphase-promoting complex subunit 1. (149 aa)
CDC16Cell division cycle protein 16 homolog. (615 aa)
LOC103268591Ubiquitin-conjugating enzyme E2 C-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (178 aa)
RFC4Replication factor C subunit 4. (363 aa)
MEIOBLOW QUALITY PROTEIN: meiosis-specific with OB domain-containing protein. (470 aa)
ENSTSYP00000017997annotation not available (123 aa)
UBE2E1Ubiquitin-conjugating enzyme E2 E1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
CDT1DNA replication factor Cdt1. (468 aa)
ENSTSYP00000019039annotation not available (232 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ENSTSYP00000019195annotation not available (162 aa)
ENSTSYP00000019245annotation not available (285 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
PSMB6Proteasome subunit beta. (242 aa)
CDC26Anaphase-promoting complex subunit CDC26 isoform X1. (85 aa)
SKP2S-phase kinase-associated protein 2. (436 aa)
ENSTSYP00000021013annotation not available (135 aa)
PSME3Proteasome activator complex subunit 3 isoform X1. (265 aa)
ENSTSYP00000021540annotation not available (291 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
ENSTSYP00000022222annotation not available (155 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa)
ENSTSYP00000023689annotation not available (139 aa)
ANAPC11Anaphase-promoting complex subunit 11 isoform X1. (84 aa)
GINS3DNA replication complex GINS protein PSF3 isoform X1. (216 aa)
UBA52ubiquitin-60S ribosomal protein L40 isoform X1. (231 aa)
ENSTSYP00000024485annotation not available (234 aa)
LIG1DNA ligase. (936 aa)
ENSTSYP00000024947annotation not available (143 aa)
ENSTSYP00000024958annotation not available (55 aa)
ENSTSYP00000025346annotation not available (194 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X2. (377 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform X1. (220 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ENSTSYP00000025727annotation not available (215 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13 isoform X1. (396 aa)
PRIM2DNA primase large subunit. (159 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
PSMB10Proteasome subunit beta. (273 aa)
ENSTSYP00000026533annotation not available (256 aa)
LOC103272490DNA primase large subunit. (206 aa)
ENSTSYP00000027147annotation not available (149 aa)
ANAPC16Anaphase-promoting complex subunit 16. (110 aa)
ENSTSYP00000027311annotation not available (388 aa)
PSMC526S protease regulatory subunit 8 isoform X2; Belongs to the AAA ATPase family. (398 aa)
ENSTSYP00000027888annotation not available (154 aa)
ENSTSYP00000028373annotation not available (134 aa)
ENSTSYP00000028450annotation not available (227 aa)
ENSTSYP00000028770annotation not available (118 aa)
FZR1Fizzy-related protein homolog. (449 aa)
LOC10325039226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (400 aa)
ANAPC2Anaphase-promoting complex subunit 2. (577 aa)
ENSTSYP00000030504annotation not available (156 aa)
UBE2CUbiquitin-conjugating enzyme E2 C isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
ENSTSYP00000030676annotation not available (108 aa)
PSMB8Proteasome subunit beta. (276 aa)
LOC103262238Proteasome subunit alpha type. (261 aa)
ENSTSYP00000031072annotation not available (165 aa)
POLD4DNA polymerase delta subunit 4. (32 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
ENSTSYP00000031721annotation not available (275 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMB5Proteasome subunit beta. (263 aa)
ENSTSYP00000032262annotation not available (99 aa)
PSME2Proteasome activator complex subunit 2 isoform X1. (254 aa)
ENSTSYP00000032718annotation not available (175 aa)
RFC2Replication factor C subunit 2 isoform X1. (352 aa)
PSMC426S protease regulatory subunit 6B isoform X1; Belongs to the AAA ATPase family. (418 aa)
ENSTSYP00000033058annotation not available (142 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
LOC110596262ubiquitin-40S ribosomal protein S27a-like. (156 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
ENSTSYP00000034042annotation not available (110 aa)
MCM4DNA helicase; Belongs to the MCM family. (860 aa)
ENSTSYP00000034634annotation not available (328 aa)
RCBTB2RCC1 and BTB domain-containing protein 2 isoform X1. (551 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (264 aa)
MCM9DNA helicase MCM9; Belongs to the MCM family. (391 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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