Your Input: | |
| | RMI2 | recQ-mediated genome instability protein 2. (147 aa) |
| | ENSTSYP00000000614 | annotation not available (191 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | RPS27A | ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1061 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (714 aa) |
| | DBF4 | Protein DBF4 homolog A. (665 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2. (620 aa) |
| | TDRD3 | LOW QUALITY PROTEIN: tudor domain-containing protein 3. (715 aa) |
| | CCNB3 | G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1107 aa) |
| | WEE2 | Wee1-like protein kinase. (567 aa) |
| | RNF169 | E3 ubiquitin-protein ligase RNF169. (632 aa) |
| | ATR | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1 isoform X1. (282 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | PSMA1 | Proteasome subunit alpha type. (264 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | HERC2 | E3 ubiquitin-protein ligase HERC2. (4829 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1. (1516 aa) |
| | MCM8 | DNA helicase MCM8; Belongs to the MCM family. (832 aa) |
| | BABAM2 | BRCA1-A complex subunit BRE. (311 aa) |
| | UIMC1 | BRCA1-A complex subunit RAP80 isoform X3. (714 aa) |
| | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14. (326 aa) |
| | PSMA4 | Proteasome subunit alpha type. (179 aa) |
| | PSMF1 | Proteasome inhibitor PI31 subunit isoform X2. (272 aa) |
| | CDC7 | Cell division cycle 7-related protein kinase isoform X1. (574 aa) |
| | PSME1 | Proteasome activator complex subunit 1 isoform X1. (250 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | YWHAZ | 14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (254 aa) |
| | TM4SF19 | Transmembrane 4 L6 family member 19 isoform X2. (209 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | LOC103266633 | Ubiquitin-conjugating enzyme E2 N-like. (152 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | BRCC3 | Lys-63-specific deubiquitinase BRCC36 isoform X1. (316 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa) |
| | EXO1 | Exonuclease 1 isoform X1. (846 aa) |
| | ORC3 | Origin recognition complex subunit 3 isoform X2. (711 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (435 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | RAD50 | DNA repair protein RAD50. (1312 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | PSMC1 | 26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | MCM10 | Protein MCM10 homolog isoform X1. (871 aa) |
| | LOC103272535 | 26S proteasome non-ATPase regulatory subunit 7. (324 aa) |
| | CDC25C | M-phase inducer phosphatase 3. (464 aa) |
| | LOC103255197 | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (150 aa) |
| | ENSTSYP00000008181 | annotation not available (412 aa) |
| | YWHAE | 14-3-3 protein epsilon isoform X2; Belongs to the 14-3-3 family. (255 aa) |
| | WDR41 | WD repeat-containing protein 41. (436 aa) |
| | RFC3 | Replication factor C subunit 3 isoform X1. (270 aa) |
| | GTSE1 | G2 and S phase-expressed protein 1. (742 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | CLSPN | Claspin isoform X1. (1334 aa) |
| | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (239 aa) |
| | PSMC6 | 26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1. (391 aa) |
| | YWHAG | 14-3-3 protein gamma; Belongs to the 14-3-3 family. (233 aa) |
| | ORC2 | Origin recognition complex subunit 2 isoform X1. (574 aa) |
| | ENSTSYP00000009770 | annotation not available (227 aa) |
| | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 isoform X1. (513 aa) |
| | PSMA7 | Proteasome endopeptidase complex. (248 aa) |
| | BRIP1 | Fanconi anemia group J protein. (1246 aa) |
| | WEE1 | Wee1-like protein kinase. (432 aa) |
| | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 isoform X1. (416 aa) |
| | PSME4 | Proteasome activator complex subunit 4 isoform X2. (1825 aa) |
| | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11. (422 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (855 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | BLM | Bloom syndrome protein isoform X1. (1413 aa) |
| | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 isoform X2. (534 aa) |
| | WRN | LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1403 aa) |
| | ORC5 | Origin recognition complex subunit 5. (309 aa) |
| | RBBP8 | DNA endonuclease RBBP8. (896 aa) |
| | RAD9B | Cell cycle checkpoint control protein RAD9B. (398 aa) |
| | ABRAXAS1 | BRCA1-A complex subunit Abraxas. (410 aa) |
| | PSMB3 | Proteasome subunit beta. (207 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (623 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12. (420 aa) |
| | RNF8 | LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF8. (486 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor protein 1. (917 aa) |
| | CCNB2 | G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa) |
| | NSD2 | LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2-like. (1364 aa) |
| | MCM5 | DNA replication licensing factor MCM5; Belongs to the MCM family. (598 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSTSYP00000014559 | annotation not available (115 aa) |
| | ENSTSYP00000014599 | annotation not available (238 aa) |
| | RFC5 | Replication factor C subunit 5 isoform X1. (339 aa) |
| | LOC103274798 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CDC25A | M-phase inducer phosphatase 1 isoform X1. (523 aa) |
| | ENSTSYP00000015668 | annotation not available (251 aa) |
| | CDK3 | Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (305 aa) |
| | ENSTSYP00000015921 | annotation not available (137 aa) |
| | PSMC3 | 26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (450 aa) |
| | LOC103259942 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | ENSTSYP00000016447 | annotation not available (103 aa) |
| | ENSTSYP00000016554 | annotation not available (103 aa) |
| | LOC103263942 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSTSYP00000016778 | annotation not available (81 aa) |
| | LOC103272232 | Ubiquitin-conjugating enzyme E2 variant 2-like. (130 aa) |
| | CDC45 | Cell division control protein 45 homolog isoform X1. (600 aa) |
| | ENSTSYP00000017516 | annotation not available (103 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | MEIOB | LOW QUALITY PROTEIN: meiosis-specific with OB domain-containing protein. (470 aa) |
| | LOC103259960 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSTSYP00000018051 | annotation not available (62 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSTSYP00000019039 | annotation not available (232 aa) |
| | ENSTSYP00000019167 | annotation not available (267 aa) |
| | ENSTSYP00000019245 | annotation not available (285 aa) |
| | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CDK1 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (297 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (230 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (699 aa) |
| | LOC103274803 | Histone H2B; Belongs to the histone H2B family. (161 aa) |
| | LOC103274810 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSTSYP00000020416 | annotation not available (132 aa) |
| | PSMB6 | Proteasome subunit beta. (242 aa) |
| | LOC103263943 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PSME3 | Proteasome activator complex subunit 3 isoform X1. (265 aa) |
| | ENSTSYP00000021540 | annotation not available (291 aa) |
| | ENSTSYP00000021542 | annotation not available (142 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (853 aa) |
| | YWHAB | 14-3-3 protein beta/alpha isoform X1; Belongs to the 14-3-3 family. (246 aa) |
| | TP53BP1 | TP53-binding protein 1 isoform X1. (1974 aa) |
| | ENSTSYP00000022222 | annotation not available (155 aa) |
| | LOC103259956 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PIAS4 | E3 SUMO-protein ligase PIAS4. (444 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa) |
| | ENSTSYP00000022737 | annotation not available (103 aa) |
| | ENSTSYP00000023067 | annotation not available (103 aa) |
| | ENSTSYP00000023161 | annotation not available (103 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2. (146 aa) |
| | LOC103259954 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa) |
| | ENSTSYP00000023903 | annotation not available (126 aa) |
| | UBA52 | ubiquitin-60S ribosomal protein L40 isoform X1. (231 aa) |
| | ENSTSYP00000024234 | annotation not available (103 aa) |
| | ENSTSYP00000024257 | annotation not available (242 aa) |
| | SFN | 14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa) |
| | ENSTSYP00000024485 | annotation not available (234 aa) |
| | YWHAQ | 14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2676 aa) |
| | ENSTSYP00000024958 | annotation not available (55 aa) |
| | ENSTSYP00000025294 | annotation not available (103 aa) |
| | ENSTSYP00000025346 | annotation not available (194 aa) |
| | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 isoform X2. (377 aa) |
| | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 isoform X1. (220 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2 isoform X1. (582 aa) |
| | ENSTSYP00000025727 | annotation not available (215 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 isoform X1. (396 aa) |
| | ENSTSYP00000026370 | annotation not available (136 aa) |
| | BABAM1 | BRISC and BRCA1-A complex member 1 isoform X1. (321 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | ENSTSYP00000026533 | annotation not available (256 aa) |
| | ENSTSYP00000026963 | annotation not available (100 aa) |
| | ENSTSYP00000027147 | annotation not available (149 aa) |
| | ENSTSYP00000027311 | annotation not available (388 aa) |
| | CDCA7L | Cell division cycle-associated 7-like protein isoform X1. (454 aa) |
| | PSMC5 | 26S protease regulatory subunit 8 isoform X2; Belongs to the AAA ATPase family. (398 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17 isoform X1. (681 aa) |
| | ENSTSYP00000027938 | annotation not available (114 aa) |
| | LOC103256252 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | ENSTSYP00000028373 | annotation not available (134 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component. (2339 aa) |
| | ENSTSYP00000028450 | annotation not available (227 aa) |
| | ENSTSYP00000028770 | annotation not available (118 aa) |
| | RAD9A | Cell cycle checkpoint control protein RAD9A. (388 aa) |
| | LOC103250392 | 26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (400 aa) |
| | YWHAH | 14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa) |
| | MCM9 | DNA helicase MCM9; Belongs to the MCM family. (391 aa) |
| | PKMYT1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Belongs to the protein kinase superfamily. (545 aa) |
| | PSMB8 | Proteasome subunit beta. (276 aa) |
| | LOC103252110 | G2/mitotic-specific cyclin-B1 isoform X1; Belongs to the cyclin family. (433 aa) |
| | LOC103262238 | Proteasome subunit alpha type. (261 aa) |
| | CNTD2 | LOW QUALITY PROTEIN: cyclin N-terminal domain-containing protein 2; Belongs to the cyclin family. (207 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (180 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (121 aa) |
| | ENSTSYP00000031721 | annotation not available (275 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | ENSTSYP00000031904 | annotation not available (126 aa) |
| | ENSTSYP00000031975 | annotation not available (103 aa) |
| | ENSTSYP00000032262 | annotation not available (99 aa) |
| | PSME2 | Proteasome activator complex subunit 2 isoform X1. (254 aa) |
| | ENSTSYP00000032718 | annotation not available (175 aa) |
| | RFC2 | Replication factor C subunit 2 isoform X1. (352 aa) |
| | PSMC4 | 26S protease regulatory subunit 6B isoform X1; Belongs to the AAA ATPase family. (418 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | ENSTSYP00000033242 | annotation not available (75 aa) |
| | ENSTSYP00000033278 | annotation not available (103 aa) |
| | LOC110596262 | ubiquitin-40S ribosomal protein S27a-like. (156 aa) |
| | LOC103253707 | DNA topoisomerase 2-binding protein 1-A-like. (154 aa) |
| | CDK2 | Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa) |
| | ENSTSYP00000033540 | annotation not available (126 aa) |
| | LOC103252213 | Breast cancer type 1 susceptibility protein-like. (97 aa) |
| | ENSTSYP00000033658 | annotation not available (79 aa) |
| | ENSTSYP00000033824 | annotation not available (103 aa) |
| | ATRIP | ATR-interacting protein isoform X1. (743 aa) |
| | ENSTSYP00000034010 | annotation not available (126 aa) |
| | ENSTSYP00000034042 | annotation not available (110 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (860 aa) |
| | ENSTSYP00000034265 | annotation not available (129 aa) |
| | ENSTSYP00000034350 | annotation not available (103 aa) |
| | ENSTSYP00000034634 | annotation not available (328 aa) |
| | RCBTB2 | RCC1 and BTB domain-containing protein 2 isoform X1. (551 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8. (264 aa) |
| | ENSTSYP00000034921 | annotation not available (296 aa) |
