STRINGSTRING
WNT5A WNT5A ENSTSYP00000024302 ENSTSYP00000024302 SH3GL3 SH3GL3 SYT8 SYT8 PICALM PICALM ARRB1 ARRB1 ENSTSYP00000026847 ENSTSYP00000026847 EPN2 EPN2 LOC103251503 LOC103251503 ENSTSYP00000027147 ENSTSYP00000027147 EPN3 EPN3 LOC103249374 LOC103249374 TACR1 TACR1 CLPB CLPB LDLR LDLR TF TF LOC103259644 LOC103259644 VAMP3 VAMP3 SYT11 SYT11 STON2 STON2 GRK3 GRK3 CBL CBL ENSTSYP00000030160 ENSTSYP00000030160 ENSTSYP00000030216 ENSTSYP00000030216 LOC103256674 LOC103256674 NECAP2 NECAP2 AP2B1 AP2B1 ENSTSYP00000030676 ENSTSYP00000030676 EPGN EPGN DVL2 DVL2 HGS HGS SYT4 SYT4 ENSTSYP00000031162 ENSTSYP00000031162 GRAP GRAP ENSTSYP00000032762 ENSTSYP00000032762 GRB2 GRB2 ZFYVE19 ZFYVE19 LOC110596262 LOC110596262 EPS15L1 EPS15L1 SGIP1 SGIP1 ENSTSYP00000033714 ENSTSYP00000033714 AP2M1 AP2M1 COPS6 COPS6 GPS1 GPS1 REPS1 REPS1 STAM2 STAM2 LOC110596808 LOC110596808 ITSN1 ITSN1 SLC18A3 SLC18A3 ENSTSYP00000014559 ENSTSYP00000014559 AGFG1 AGFG1 SCARB2 SCARB2 AVP AVP NECAP1 NECAP1 SYT2 SYT2 LDLRAP1 LDLRAP1 ENSTSYP00000016178 ENSTSYP00000016178 AVPR2 AVPR2 AP2A1 AP2A1 CD3D CD3D COPS7B COPS7B BMP2K BMP2K FCHO2 FCHO2 ENSTSYP00000017875 ENSTSYP00000017875 ENSTSYP00000017967 ENSTSYP00000017967 M6PR M6PR TOR1B TOR1B GPR52 GPR52 ENSTSYP00000020174 ENSTSYP00000020174 ENSTSYP00000017997 ENSTSYP00000017997 COPS5 COPS5 TOR1A TOR1A AREG AREG VAMP4 VAMP4 EPS15 EPS15 HBEGF HBEGF COPS4 COPS4 NETO1 NETO1 CHRM2 CHRM2 IL7R IL7R AP2A2 AP2A2 COPS7A COPS7A PPP1R42 PPP1R42 SYT1 SYT1 MCTP1 MCTP1 AGTR1 AGTR1 MCTP2 MCTP2 SH3GL2 SH3GL2 KIAA0319 KIAA0319 UBQLN4 UBQLN4 UBL7 UBL7 GRK2 GRK2 CLTC CLTC TGFA TGFA NEDD8 NEDD8 ENSTSYP00000022222 ENSTSYP00000022222 AP2S1 AP2S1 ENSTSYP00000022366 ENSTSYP00000022366 ARRB2 ARRB2 FZD4 FZD4 CLTA CLTA ENSTSYP00000023051 ENSTSYP00000023051 ENSTSYP00000023302 ENSTSYP00000023302 VAMP7 VAMP7 ENSTSYP00000023710 ENSTSYP00000023710 AGFG2 AGFG2 UBA52 UBA52 ENSTSYP00000024017 ENSTSYP00000024017 DAB2 DAB2 SNAP91 SNAP91 TGOLN2 TGOLN2 EREG EREG NETO2 NETO2 IGF2R IGF2R SH3KBP1 SH3KBP1 EGFR EGFR SLC2A8 SLC2A8 LMBRD2 LMBRD2 LOC103260774 LOC103260774 VAMP2 VAMP2 UBQLN2 UBQLN2 COPS2 COPS2 APOB APOB STON1 STON1 GPR21 GPR21 SYT9 SYT9 UBQLN1 UBQLN1 ITSN2 ITSN2 LOC103268533 LOC103268533 EGF EGF VAMP8 VAMP8 ENTHD1 ENTHD1 ZFYVE1 ZFYVE1 CLHC1 CLHC1 ARR3 ARR3 CFTR CFTR RPS27A RPS27A TFRC TFRC REPS2 REPS2 CLTCL1 CLTCL1 BTC BTC VAMP5 VAMP5 COPS3 COPS3 CD3G CD3G STAM STAM KIAA0319L KIAA0319L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ENSTSYP00000024302annotation not available (195 aa)
SH3GL3endophilin-A3. (289 aa)
SYT8LOW QUALITY PROTEIN: synaptotagmin-8. (362 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein isoform X11. (652 aa)
ARRB1Beta-arrestin-1. (435 aa)
ENSTSYP00000026847annotation not available (173 aa)
EPN2Epsin-2. (640 aa)
LOC103251503LOW QUALITY PROTEIN: epsin-1-like. (321 aa)
ENSTSYP00000027147annotation not available (149 aa)
EPN3Epsin-3. (551 aa)
LOC103249374COP9 signalosome complex subunit 8. (209 aa)
TACR1substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CLPBCaseinolytic peptidase B protein homolog isoform X2. (684 aa)
LDLRLow-density lipoprotein receptor. (668 aa)
TFLOW QUALITY PROTEIN: serotransferrin-like. (697 aa)
LOC103259644AP2-associated protein kinase 1-like. (120 aa)
VAMP3Vesicle associated membrane protein 3. (102 aa)
SYT11Synaptotagmin-11 isoform X1. (431 aa)
STON2Stonin-2; Belongs to the Stoned B family. (757 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (609 aa)
CBLE3 ubiquitin-protein ligase CBL. (898 aa)
ENSTSYP00000030160annotation not available (59 aa)
ENSTSYP00000030216annotation not available (710 aa)
LOC103256674LOW QUALITY PROTEIN: arf-GAP domain and FG repeat-containing protein 1-like. (465 aa)
NECAP2Adaptin ear-binding coat-associated protein 2. (273 aa)
AP2B1AP complex subunit beta. (937 aa)
ENSTSYP00000030676annotation not available (108 aa)
EPGNEpigen isoform X1. (153 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (736 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
SYT4Synaptotagmin-4 isoform X1. (425 aa)
ENSTSYP00000031162annotation not available (172 aa)
GRAPGRB2-related adapter protein. (188 aa)
ENSTSYP00000032762annotation not available (114 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
ZFYVE19abscission/NoCut checkpoint regulator isoform X2. (465 aa)
LOC110596262ubiquitin-40S ribosomal protein S27a-like. (156 aa)
EPS15L1Epidermal growth factor receptor substrate 15-like 1 isoform X1. (900 aa)
SGIP1SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1. (826 aa)
ENSTSYP00000033714annotation not available (695 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (452 aa)
COPS6COP9 signalosome complex subunit 6. (269 aa)
GPS1COP9 signalosome complex subunit 1 isoform X1. (527 aa)
REPS1ralBP1-associated Eps domain-containing protein 1 isoform X1. (793 aa)
STAM2Signal transducing adapter molecule 2. (525 aa)
LOC110596808LOW QUALITY PROTEIN: vesicle-associated membrane protein 3-like. (87 aa)
ITSN1Intersectin-1. (1721 aa)
SLC18A3Vesicular acetylcholine transporter. (532 aa)
ENSTSYP00000014559annotation not available (115 aa)
AGFG1arf-GAP domain and FG repeat-containing protein 1 isoform X2. (584 aa)
SCARB2Lysosome membrane protein 2; Belongs to the CD36 family. (386 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (107 aa)
NECAP1Adaptin ear-binding coat-associated protein 1. (274 aa)
SYT2Synaptotagmin-2 isoform X1. (419 aa)
LDLRAP1Low density lipoprotein receptor adapter protein 1. (280 aa)
ENSTSYP00000016178annotation not available (128 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (370 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (911 aa)
CD3DT-cell surface glycoprotein CD3 delta chain isoform X1. (171 aa)
COPS7BCOP9 signalosome complex subunit 7b isoform X1. (264 aa)
BMP2KLOW QUALITY PROTEIN: BMP-2-inducible protein kinase. (570 aa)
FCHO2F-BAR domain only protein 2 isoform X1. (810 aa)
ENSTSYP00000017875annotation not available (257 aa)
ENSTSYP00000017967annotation not available (148 aa)
M6PRCation-dependent mannose-6-phosphate receptor isoform X1. (278 aa)
TOR1BTorsin. (336 aa)
GPR52Probable G-protein coupled receptor 52; Belongs to the G-protein coupled receptor 1 family. (361 aa)
ENSTSYP00000020174annotation not available (198 aa)
ENSTSYP00000017997annotation not available (123 aa)
COPS5COP9 signalosome complex subunit 5 isoform X1. (334 aa)
TOR1Atorsin-1A. (332 aa)
AREGAmphiregulin isoform X1. (270 aa)
VAMP4Vesicle-associated membrane protein 4 isoform X1. (141 aa)
EPS15Epidermal growth factor receptor substrate 15 isoform X2. (899 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
COPS4COP9 signalosome complex subunit 4 isoform X1. (425 aa)
NETO1Neuropilin and tolloid-like protein 1. (533 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
IL7RInterleukin-7 receptor subunit alpha. (459 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (928 aa)
COPS7ACOP9 signalosome complex subunit 7a. (275 aa)
PPP1R42Protein phosphatase 1 regulatory subunit 42. (340 aa)
SYT1Synaptotagmin-1 isoform X1. (422 aa)
MCTP1Multiple C2 and transmembrane domain-containing protein 1 isoform X1. (758 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
MCTP2Multiple C2 and transmembrane domain-containing protein 2 isoform X1. (877 aa)
SH3GL2endophilin-A1 isoform X2. (350 aa)
KIAA0319Dyslexia-associated protein KIAA0319 homolog. (914 aa)
UBQLN4Ubiquilin-4. (601 aa)
UBL7Ubiquitin-like protein 7 isoform X1. (380 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (621 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
TGFATransforming growth factor alpha. (164 aa)
NEDD8NEDD8. (81 aa)
ENSTSYP00000022222annotation not available (155 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (159 aa)
ENSTSYP00000022366annotation not available (128 aa)
ARRB2Beta-arrestin-2 isoform X2. (409 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (507 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (236 aa)
ENSTSYP00000023051annotation not available (95 aa)
ENSTSYP00000023302annotation not available (173 aa)
VAMP7Vesicle-associated membrane protein 7 isoform X1; Belongs to the synaptobrevin family. (220 aa)
ENSTSYP00000023710annotation not available (79 aa)
AGFG2arf-GAP domain and FG repeat-containing protein 2. (430 aa)
UBA52ubiquitin-60S ribosomal protein L40 isoform X1. (231 aa)
ENSTSYP00000024017annotation not available (120 aa)
DAB2Disabled homolog 2. (769 aa)
SNAP91Clathrin coat assembly protein AP180. (858 aa)
TGOLN2trans-Golgi network integral membrane protein 2. (438 aa)
EREGProepiregulin. (167 aa)
NETO2Neuropilin and tolloid-like protein 2 isoform X1. (525 aa)
IGF2RCation-independent mannose-6-phosphate receptor. (2180 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1 isoform X1. (569 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (401 aa)
LMBRD2LMBR1 domain-containing protein 2. (695 aa)
LOC103260774AP2-associated protein kinase 1. (399 aa)
VAMP2Vesicle-associated membrane protein 2 isoform X2. (118 aa)
UBQLN2Ubiquilin-2 isoform X1. (623 aa)
COPS2COP9 signalosome complex subunit 2 isoform X1. (458 aa)
APOBApolipoprotein B-100. (4537 aa)
STON1Stonin-1; Belongs to the Stoned B family. (736 aa)
GPR21Probable G-protein coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (349 aa)
SYT9Synaptotagmin-9. (491 aa)
UBQLN1Ubiquilin-1. (589 aa)
ITSN2Intersectin-2 isoform X1. (1662 aa)
LOC103268533Low-density lipoprotein receptor-related protein 2-like. (1223 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
ENTHD1ENTH domain-containing protein 1. (430 aa)
ZFYVE1Zinc finger FYVE domain-containing protein 1 isoform X1. (779 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1. (586 aa)
ARR3arrestin-C. (388 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1480 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
TFRCTransferrin receptor protein 1. (760 aa)
REPS2ralBP1-associated Eps domain-containing protein 2. (641 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa)
BTCProbetacellulin. (178 aa)
VAMP5Vesicle-associated membrane protein 5. (115 aa)
COPS3COP9 signalosome complex subunit 3 isoform X2. (423 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (181 aa)
STAMSignal transducing adapter molecule 1 isoform X1. (538 aa)
KIAA0319LDyslexia-associated protein KIAA0319-like protein homolog. (1051 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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