STRINGSTRING
ENSTSYP00000023484 ENSTSYP00000023484 APP APP ENSTSYP00000022222 ENSTSYP00000022222 PPP2R5D PPP2R5D LRRC74B LRRC74B BTRC BTRC DUSP3 DUSP3 MAPK15 MAPK15 N4BP1 N4BP1 MAPKAPK2 MAPKAPK2 RPS6KA1 RPS6KA1 ATF7 ATF7 RPS6KA2 RPS6KA2 TAB1 TAB1 MEF2C MEF2C KHNYN KHNYN LOC103275450 LOC103275450 MAPK1 MAPK1 LRRC71 LRRC71 ENSTSYP00000032288 ENSTSYP00000032288 AGER AGER MAPK7 MAPK7 ENSTSYP00000033058 ENSTSYP00000033058 NLRP1 NLRP1 ENSTSYP00000033242 ENSTSYP00000033242 LOC110596262 LOC110596262 LRRC14 LRRC14 ENSTSYP00000034157 ENSTSYP00000034157 VWC2 VWC2 PELI1 PELI1 ENSTSYP00000021542 ENSTSYP00000021542 ENSTSYP00000021013 ENSTSYP00000021013 NLRX1 NLRX1 FOSL2 FOSL2 TNIP2 TNIP2 MEF2A MEF2A ENSTSYP00000019525 ENSTSYP00000019525 TLR7 TLR7 CREM CREM ENSTSYP00000019212 ENSTSYP00000019212 MAP2K1 MAP2K1 ENSTSYP00000018213 ENSTSYP00000018213 ENSTSYP00000017997 ENSTSYP00000017997 DUSP4 DUSP4 PPP2R1A PPP2R1A LOC103255929 LOC103255929 NOD2 NOD2 USP14 USP14 ENSTSYP00000016692 ENSTSYP00000016692 PPP2R1B PPP2R1B FBXW11 FBXW11 TRAF6 TRAF6 IRF7 IRF7 TONSL TONSL LOC103267688 LOC103267688 DUSP7 DUSP7 TAB3 TAB3 ENSTSYP00000027938 ENSTSYP00000027938 MAPK3 MAPK3 ENSTSYP00000027147 ENSTSYP00000027147 PELI3 PELI3 ENSTSYP00000027085 ENSTSYP00000027085 VRK3 VRK3 MAPK11 MAPK11 IKBKG IKBKG ATF1 ATF1 ENSTSYP00000026370 ENSTSYP00000026370 MAPK8 MAPK8 NKIRAS1 NKIRAS1 LRRC74A LRRC74A LOC103254497 LOC103254497 ENSTSYP00000024947 ENSTSYP00000024947 S100B S100B RELA RELA ENSTSYP00000024219 ENSTSYP00000024219 MAP2K6 MAP2K6 UBA52 UBA52 TP53 TP53 ENSTSYP00000023689 ENSTSYP00000023689 PELI2 PELI2 NLRC5 NLRC5 CUL1 CUL1 ENSTSYP00000015921 ENSTSYP00000015921 LRRC45 LRRC45 LOC103254894 LOC103254894 ENSTSYP00000014559 ENSTSYP00000014559 MAP2K4 MAP2K4 LOC103254100 LOC103254100 PPP2CA PPP2CA MAP2K7 MAP2K7 ALPK1 ALPK1 LOC103265125 LOC103265125 NLRP10 NLRP10 PPP2CB PPP2CB FNBP4 FNBP4 RPS6KA5 RPS6KA5 MAP3K20 MAP3K20 ENSTSYP00000011534 ENSTSYP00000011534 RPS6KA3 RPS6KA3 LOC103265120 LOC103265120 MAP3K8 MAP3K8 SKP1 SKP1 PPP4R1 PPP4R1 NKIRAS2 NKIRAS2 MAP3K1 MAP3K1 S100A12 S100A12 LOC103255197 LOC103255197 TAB2 TAB2 MYD88 MYD88 ELK1 ELK1 ENSTSYP00000006680 ENSTSYP00000006680 CREB1 CREB1 LOC103266633 LOC103266633 RELCH RELCH RIPK2 RIPK2 MAPK10 MAPK10 MAP2K3 MAP2K3 CREB5 CREB5 ECSIT ECSIT NFKB1 NFKB1 PPP4R4 PPP4R4 CHUK CHUK NFKBIA NFKBIA NLRP9 NLRP9 TLR4 TLR4 IKBKB IKBKB ATF2 ATF2 DZIP3 DZIP3 NFKBIB NFKBIB IRAK2 IRAK2 MAPKAPK3 MAPKAPK3 IRAK4 IRAK4 MAPK14 MAPK14 NOD1 NOD1 RPS27A RPS27A CD14 CD14 LY96 LY96 DUSP6 DUSP6 MAPK9 MAPK9 IRAK1 IRAK1 MAP3K7 MAP3K7 ENSTSYP00000030676 ENSTSYP00000030676 CASP8 CASP8 ENSTSYP00000030504 ENSTSYP00000030504 LRRC34 LRRC34 HMGB1 HMGB1 FOS FOS ENSTSYP00000029633 ENSTSYP00000029633
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSTSYP00000023484annotation not available (413 aa)
APPAmyloid beta A4 protein isoform X1. (765 aa)
ENSTSYP00000022222annotation not available (155 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
LRRC74BLOW QUALITY PROTEIN: leucine-rich repeat-containing protein 74B. (340 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (589 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (169 aa)
MAPK15Mitogen-activated protein kinase. (277 aa)
N4BP1NEDD4-binding protein 1. (892 aa)
MAPKAPK2MAP kinase-activated protein kinase 2. (400 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7 isoform X2. (483 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (729 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2. (504 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
KHNYNProtein KHNYN. (672 aa)
LOC103275450High mobility group protein B1-like isoform X1. (215 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
LRRC71Leucine-rich repeat-containing protein 71. (419 aa)
ENSTSYP00000032288annotation not available (403 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X2. (403 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (813 aa)
ENSTSYP00000033058annotation not available (142 aa)
NLRP1LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 1. (1435 aa)
ENSTSYP00000033242annotation not available (75 aa)
LOC110596262ubiquitin-40S ribosomal protein S27a-like. (156 aa)
LRRC14Leucine-rich repeat-containing protein 14. (493 aa)
ENSTSYP00000034157annotation not available (419 aa)
VWC2Brorin. (325 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ENSTSYP00000021542annotation not available (142 aa)
ENSTSYP00000021013annotation not available (135 aa)
NLRX1NLR family member X1. (974 aa)
FOSL2Fos-related antigen 2. (292 aa)
TNIP2TNFAIP3-interacting protein 2. (366 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (498 aa)
ENSTSYP00000019525annotation not available (204 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
CREMcAMP-responsive element modulator isoform X7. (111 aa)
ENSTSYP00000019212annotation not available (259 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
ENSTSYP00000018213annotation not available (184 aa)
ENSTSYP00000017997annotation not available (123 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (393 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (589 aa)
LOC103255929Toll-like receptor 9 isoform X2. (1029 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1040 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (492 aa)
ENSTSYP00000016692annotation not available (64 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3. (667 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (533 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (512 aa)
IRF7Interferon regulatory factor 7. (133 aa)
TONSLTonsoku-like protein. (1382 aa)
LOC103267688Inactive serine/threonine-protein kinase VRK3-like isoform X2. (419 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (711 aa)
ENSTSYP00000027938annotation not available (114 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
ENSTSYP00000027147annotation not available (149 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
ENSTSYP00000027085annotation not available (426 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X1. (473 aa)
MAPK11Mitogen-activated protein kinase. (255 aa)
IKBKGNF-kappa-B essential modulator. (460 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X1. (269 aa)
ENSTSYP00000026370annotation not available (136 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa)
LRRC74ALeucine-rich repeat-containing protein 74A. (504 aa)
LOC103254497lisH domain and HEAT repeat-containing protein KIAA1468-like. (391 aa)
ENSTSYP00000024947annotation not available (143 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
RELATranscription factor p65. (519 aa)
ENSTSYP00000024219annotation not available (592 aa)
MAP2K6LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (352 aa)
UBA52ubiquitin-60S ribosomal protein L40 isoform X1. (231 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
ENSTSYP00000023689annotation not available (139 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog 2. (420 aa)
NLRC5Protein NLRC5. (1843 aa)
CUL1Cullin-1 isoform X1; Belongs to the cullin family. (776 aa)
ENSTSYP00000015921annotation not available (137 aa)
LRRC45Leucine-rich repeat-containing protein 45. (670 aa)
LOC103254894Ubiquitin-conjugating enzyme E2 variant 1-like. (163 aa)
ENSTSYP00000014559annotation not available (115 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (387 aa)
LOC103254100Ubiquitin-conjugating enzyme E2 variant 1-like. (135 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (414 aa)
ALPK1Alpha-protein kinase 1. (1048 aa)
LOC103265125Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
NLRP10NACHT, LRR and PYD domains-containing protein 10. (665 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
FNBP4Formin-binding protein 4 isoform X2. (669 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (594 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (801 aa)
ENSTSYP00000011534annotation not available (190 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (729 aa)
LOC103265120Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (120 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
SKP1S-phase kinase-associated protein 1 isoform X2; Belongs to the SKP1 family. (163 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (803 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1. (213 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1346 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
LOC103255197Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (150 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (430 aa)
ENSTSYP00000006680annotation not available (255 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
LOC103266633Ubiquitin-conjugating enzyme E2 N-like. (152 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (721 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2 isoform X1. (539 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
ECSITEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1. (431 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X7. (809 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
NFKBIANF-kappa-B inhibitor alpha. (282 aa)
NLRP9NACHT, LRR and PYD domains-containing protein 9. (992 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (840 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (507 aa)
DZIP3E3 ubiquitin-protein ligase DZIP3. (1207 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (343 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (626 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (383 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
CD14Monocyte differentiation antigen CD14. (376 aa)
LY96Lymphocyte antigen 96 isoform X1. (160 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (618 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSTSYP00000030676annotation not available (108 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (521 aa)
ENSTSYP00000030504annotation not available (156 aa)
LRRC34Leucine-rich repeat-containing protein 34. (419 aa)
HMGB1High mobility group protein B1. (215 aa)
FOSProto-oncogene c-Fos. (379 aa)
ENSTSYP00000029633annotation not available (134 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
Server load: low (12%) [HD]