(39 nodes) Terpenoid backbone biosynthesis network (Carlito syrichta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	IDI1	Isopentenyl-diphosphate Delta-isomerase 1. (237 aa)
	SLC35F1	Solute carrier family 35 member F1. (347 aa)
	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. (379 aa)
	LOC103272125	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (269 aa)
	NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
	TOMM70	Mitochondrial import receptor subunit TOM70. (606 aa)
	ACAT2	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	PDSS2	Decaprenyl-diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (400 aa)
	PCYOX1	Prenylcysteine oxidase 1. (505 aa)
	PDSS1	Decaprenyl-diphosphate synthase subunit 1 isoform X1; Belongs to the FPP/GGPP synthase family. (269 aa)
	SLC35F2	Solute carrier family 35 member F2. (336 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (875 aa)
	CARTPT	CART prepropeptide. (116 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
	ACAT1	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
	FDPS	Farnesyl pyrophosphate synthase isoform X1. (248 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (887 aa)
	RCE1	CAAX prenyl protease 2 isoform X1. (304 aa)
	DHDDS	Alkyl transferase; Belongs to the UPP synthase family. (334 aa)
	CHURC1	Protein Churchill isoform X1. (137 aa)
	ENSTSYP00000018246	annotation not available (99 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	RUSC2	Iporin isoform X1. (1507 aa)
	ENSTSYP00000021796	annotation not available (99 aa)
	FBXO30	F-box only protein 30. (747 aa)
	RUSC1	RUN and SH3 domain-containing protein 1. (209 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	GGPS1	Geranylgeranyl pyrophosphate synthase isoform X1; Belongs to the FPP/GGPP synthase family. (300 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (887 aa)
	ENSTSYP00000027733	annotation not available (364 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (273 aa)
	FNTB	Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. (437 aa)
	ICMT	Protein-S-isoprenylcysteine O-methyltransferase. (294 aa)
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (431 aa)
	LOC103273076	Decaprenyl-diphosphate synthase subunit 1. (97 aa)
	ZC3HC1	Nuclear-interacting partner of ALK isoform X1. (502 aa)
	PCYOX1L	Prenylcysteine oxidase-like. (493 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	ACAT2	ENSTSYP00000011599	ENSTSYP00000003501	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	0.882
ACAT1	GGPS1	ENSTSYP00000011599	ENSTSYP00000026841	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	Geranylgeranyl pyrophosphate synthase isoform X1; Belongs to the FPP/GGPP synthase family.	0.449
ACAT1	HMGCR	ENSTSYP00000011599	ENSTSYP00000027413	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.573
ACAT1	HMGCS1	ENSTSYP00000011599	ENSTSYP00000027891	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.987
ACAT1	HMGCS2	ENSTSYP00000011599	ENSTSYP00000026592	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.990
ACAT1	IDI1	ENSTSYP00000011599	ENSTSYP00000000701	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	Isopentenyl-diphosphate Delta-isomerase 1.	0.530
ACAT1	LOC103272125	ENSTSYP00000011599	ENSTSYP00000002446	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.987
ACAT1	MVD	ENSTSYP00000011599	ENSTSYP00000031183	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.736
ACAT1	MVK	ENSTSYP00000011599	ENSTSYP00000011465	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.880
ACAT1	PMVK	ENSTSYP00000011599	ENSTSYP00000020580	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	Phosphomevalonate kinase.	0.435
ACAT2	ACAT1	ENSTSYP00000003501	ENSTSYP00000011599	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.	0.882
ACAT2	FDPS	ENSTSYP00000003501	ENSTSYP00000012461	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	Farnesyl pyrophosphate synthase isoform X1.	0.543
ACAT2	GGPS1	ENSTSYP00000003501	ENSTSYP00000026841	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	Geranylgeranyl pyrophosphate synthase isoform X1; Belongs to the FPP/GGPP synthase family.	0.449
ACAT2	HMGCR	ENSTSYP00000003501	ENSTSYP00000027413	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.661
ACAT2	HMGCS1	ENSTSYP00000003501	ENSTSYP00000027891	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.988
ACAT2	HMGCS2	ENSTSYP00000003501	ENSTSYP00000026592	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.986
ACAT2	IDI1	ENSTSYP00000003501	ENSTSYP00000000701	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	Isopentenyl-diphosphate Delta-isomerase 1.	0.669
ACAT2	LOC103272125	ENSTSYP00000003501	ENSTSYP00000002446	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.988
ACAT2	MVD	ENSTSYP00000003501	ENSTSYP00000031183	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.736
ACAT2	MVK	ENSTSYP00000003501	ENSTSYP00000011465	acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.884