STRINGSTRING
PIK3CB PIK3CB IL6R IL6R LOC103268849 LOC103268849 MET MET SOS2 SOS2 IGF1R IGF1R SOS1 SOS1 HRAS HRAS CSDE1 CSDE1 PRKCA PRKCA PLCG1 PLCG1 PIK3CA PIK3CA KDR KDR KRAS KRAS PDGFRA PDGFRA EGFR EGFR JAK1 JAK1 GAB1 GAB1 RAF1 RAF1 CEP152 CEP152 BRAF BRAF EGF EGF NF1 NF1 FGFR2 FGFR2 JAK2 JAK2 EIF4E EIF4E AKT3 AKT3 PDGFC PDGFC SHC1 SHC1 BCL2L11 BCL2L11 PRKCB PRKCB PDGFD PDGFD STAT3 STAT3 MTOR MTOR HGF HGF EIF4E2 EIF4E2 SHC4 SHC4 BCL2L1 BCL2L1 ERBB2 ERBB2 ENSTSYP00000014856 ENSTSYP00000014856 AKT2 AKT2 PLCG2 PLCG2 GSK3B GSK3B ENSTSYP00000016630 ENSTSYP00000016630 ENSTSYP00000016731 ENSTSYP00000016731 GAS6 GAS6 ENSTSYP00000017269 ENSTSYP00000017269 NRG2 NRG2 MAP2K1 MAP2K1 EIF4E1B EIF4E1B AXL AXL VEGFA VEGFA LOC103267910 LOC103267910 RPS6KB1 RPS6KB1 PIK3R1 PIK3R1 ENSTSYP00000021792 ENSTSYP00000021792 ENSTSYP00000021856 ENSTSYP00000021856 TGFA TGFA RPS6 RPS6 ENSTSYP00000023992 ENSTSYP00000023992 SHC3 SHC3 NRAS NRAS FGFR3 FGFR3 PIK3R3 PIK3R3 LOC103251709 LOC103251709 NRG1 NRG1 MAPK3 MAPK3 PDGFRB PDGFRB IGF1 IGF1 ARAF ARAF PDGFB PDGFB PIK3CD PIK3CD ENSTSYP00000030405 ENSTSYP00000030405 ENSTSYP00000030772 ENSTSYP00000030772 AKT1 AKT1 RPS6KB2 RPS6KB2 PTEN PTEN IL6 IL6 ENSTSYP00000031894 ENSTSYP00000031894 MAPK1 MAPK1 BAX BAX GRB2 GRB2 ENSTSYP00000033115 ENSTSYP00000033115 LOC103277171 LOC103277171 SRC SRC PDGFA PDGFA PRKCG PRKCG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
LOC103268849Tubulin-specific chaperone A; Belongs to the TBCA family. (121 aa)
METHepatocyte growth factor receptor isoform X1. (1415 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
PRKCAProtein kinase C. (614 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
KRASGTPase KRas isoform X1. (189 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
JAK1Tyrosine-protein kinase. (1140 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (700 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
CEP152Centrosomal protein of 152 kDa. (1704 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
NF1Neurofibromin isoform X2. (2839 aa)
FGFR2Fibroblast growth factor receptor 2 isoform X1. (615 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (345 aa)
SHC1SHC-transforming protein 1 isoform X1. (474 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (200 aa)
PRKCBNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (531 aa)
PDGFDPlatelet-derived growth factor D. (370 aa)
STAT3Signal transducer and activator of transcription 3. (444 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X2; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
SHC4SHC-transforming protein 4. (629 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ENSTSYP00000014856annotation not available (69 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (403 aa)
ENSTSYP00000016630annotation not available (227 aa)
ENSTSYP00000016731annotation not available (218 aa)
GAS6Growth arrest-specific protein 6. (440 aa)
ENSTSYP00000017269annotation not available (84 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (243 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (228 aa)
AXLTyrosine-protein kinase receptor UFO isoform X1. (894 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
LOC103267910Fibroblast growth factor receptor 2-like. (208 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
ENSTSYP00000021792annotation not available (85 aa)
ENSTSYP00000021856annotation not available (88 aa)
TGFATransforming growth factor alpha. (164 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ENSTSYP00000023992annotation not available (192 aa)
SHC3SHC-transforming protein 3. (107 aa)
NRASGTPase NRas. (189 aa)
FGFR3Fibroblast growth factor receptor. (745 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
ENSTSYP00000030405annotation not available (247 aa)
ENSTSYP00000030772annotation not available (208 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IL6Interleukin-6. (209 aa)
ENSTSYP00000031894annotation not available (263 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
ENSTSYP00000033115annotation not available (96 aa)
LOC103277171LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like. (248 aa)
SRCTyrosine-protein kinase. (542 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
PRKCGProtein kinase C. (634 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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