(43 nodes) Mismatch repair network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	PRKRIP1	PRKR-interacting protein 1. (186 aa)
	STN1	CST complex subunit STN1. (364 aa)
	MSH5	mutS protein homolog 5. (835 aa)
	PMS2	Mismatch repair endonuclease PMS2 isoform X2. (862 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	MLH1	DNA mismatch repair protein Mlh1 isoform X1. (757 aa)
	MSH3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1122 aa)
	EXO1	Exonuclease 1 isoform X1. (846 aa)
	POLD3	DNA polymerase delta subunit 3 isoform X2. (425 aa)
	RFC3	Replication factor C subunit 3 isoform X1. (270 aa)
	ATAD5	ATPase family AAA domain-containing protein 5-like. (1204 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (925 aa)
	RPA2	Replication protein A 32 kDa subunit. (231 aa)
	SASS6	Spindle assembly abnormal protein 6 homolog. (656 aa)
	POLD2	DNA polymerase delta subunit 2. (469 aa)
	AEN	Apoptosis-enhancing nuclease. (325 aa)
	MSH4	mutS protein homolog 4. (854 aa)
	RFC1	Replication factor C subunit 1. (1147 aa)
	PPIL3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
	RFC5	Replication factor C subunit 5 isoform X1. (339 aa)
	RPA4	Replication protein A 30 kDa subunit. (261 aa)
	ISG20L2	Interferon-stimulated 20 kDa exonuclease-like 2. (354 aa)
	PMS1	PMS1 protein homolog 1 isoform X1. (931 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	MEIOB	LOW QUALITY PROTEIN: meiosis-specific with OB domain-containing protein. (470 aa)
	RFC2	Replication factor C subunit 2 isoform X1. (352 aa)
	ISG20	Interferon-stimulated gene 20 kDa protein isoform X1. (181 aa)
	ENSTSYP00000034634	annotation not available (328 aa)
	REXO4	RNA exonuclease 4 isoform X1. (418 aa)
	CABP5	Calcium-binding protein 5. (173 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	MLH3	DNA mismatch repair protein Mlh3 isoform X1. (1455 aa)
	SSBP1	Single-stranded DNA-binding protein, mitochondrial. (148 aa)
	ENSTSYP00000022986	annotation not available (803 aa)
	POLD1	DNA polymerase. (1094 aa)
	FBH1	F-box DNA helicase 1. (1037 aa)
	LIG1	DNA ligase. (936 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1300 aa)
	ENSTSYP00000026533	annotation not available (256 aa)
	RAD17	Cell cycle checkpoint protein RAD17 isoform X1. (681 aa)
	POLD4	DNA polymerase delta subunit 4. (32 aa)
	CCDC94	Coiled-coil domain-containing protein 94. (322 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	ENSTSYP00000034634	ENSTSYP00000011389	ENSTSYP00000034634	Apoptosis-enhancing nuclease.	annotation not available	0.548
AEN	FBH1	ENSTSYP00000011389	ENSTSYP00000024046	Apoptosis-enhancing nuclease.	F-box DNA helicase 1.	0.821
AEN	PCNA	ENSTSYP00000011389	ENSTSYP00000019084	Apoptosis-enhancing nuclease.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.947
AEN	RAD17	ENSTSYP00000011389	ENSTSYP00000027714	Apoptosis-enhancing nuclease.	Cell cycle checkpoint protein RAD17 isoform X1.	0.543
AEN	RFC2	ENSTSYP00000011389	ENSTSYP00000032840	Apoptosis-enhancing nuclease.	Replication factor C subunit 2 isoform X1.	0.543
AEN	RFC3	ENSTSYP00000011389	ENSTSYP00000008722	Apoptosis-enhancing nuclease.	Replication factor C subunit 3 isoform X1.	0.548
AEN	RFC4	ENSTSYP00000011389	ENSTSYP00000017700	Apoptosis-enhancing nuclease.	Replication factor C subunit 4.	0.543
AEN	RFC5	ENSTSYP00000011389	ENSTSYP00000014721	Apoptosis-enhancing nuclease.	Replication factor C subunit 5 isoform X1.	0.543
AEN	SSBP1	ENSTSYP00000011389	ENSTSYP00000020552	Apoptosis-enhancing nuclease.	Single-stranded DNA-binding protein, mitochondrial.	0.546
ATAD5	ENSTSYP00000022986	ENSTSYP00000009057	ENSTSYP00000022986	ATPase family AAA domain-containing protein 5-like.	annotation not available	0.472
ATAD5	ENSTSYP00000026533	ENSTSYP00000009057	ENSTSYP00000026533	ATPase family AAA domain-containing protein 5-like.	annotation not available	0.866
ATAD5	ENSTSYP00000034634	ENSTSYP00000009057	ENSTSYP00000034634	ATPase family AAA domain-containing protein 5-like.	annotation not available	0.993
ATAD5	EXO1	ENSTSYP00000009057	ENSTSYP00000006186	ATPase family AAA domain-containing protein 5-like.	Exonuclease 1 isoform X1.	0.980
ATAD5	FBH1	ENSTSYP00000009057	ENSTSYP00000024046	ATPase family AAA domain-containing protein 5-like.	F-box DNA helicase 1.	0.832
ATAD5	LIG1	ENSTSYP00000009057	ENSTSYP00000024850	ATPase family AAA domain-containing protein 5-like.	DNA ligase.	0.908
ATAD5	MEIOB	ENSTSYP00000009057	ENSTSYP00000017799	ATPase family AAA domain-containing protein 5-like.	LOW QUALITY PROTEIN: meiosis-specific with OB domain-containing protein.	0.866
ATAD5	MLH1	ENSTSYP00000009057	ENSTSYP00000004931	ATPase family AAA domain-containing protein 5-like.	DNA mismatch repair protein Mlh1 isoform X1.	0.512
ATAD5	MSH2	ENSTSYP00000009057	ENSTSYP00000009171	ATPase family AAA domain-containing protein 5-like.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.472
ATAD5	MSH3	ENSTSYP00000009057	ENSTSYP00000005403	ATPase family AAA domain-containing protein 5-like.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.505
ATAD5	MSH6	ENSTSYP00000009057	ENSTSYP00000025418	ATPase family AAA domain-containing protein 5-like.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.626