STRINGSTRING
FANCG FANCG RMI2 RMI2 FANCA FANCA BRCA2 BRCA2 N4BP2L1 N4BP2L1 ERCC4 ERCC4 RAD51 RAD51 UBE2T UBE2T PMS2 PMS2 ATR ATR FANCD2 FANCD2 RPA1 RPA1 N4BP2 N4BP2 POLK POLK MLH1 MLH1 TOP3A TOP3A TOP3B TOP3B FANCB FANCB RAD51C RAD51C POLQ POLQ SLX4 SLX4 POLI POLI RPA2 RPA2 SASS6 SASS6 BRIP1 BRIP1 REV3L REV3L REV1 REV1 EME1 EME1 BLM BLM MICAL2 MICAL2 FANCI FANCI MICALCL MICALCL FANCC FANCC FAN1 FAN1 PALB2 PALB2 TELO2 TELO2 USP1 USP1 ATRIP ATRIP ENSTSYP00000033658 ENSTSYP00000033658 MUS81 MUS81 LOC103252213 LOC103252213 PAPD4 PAPD4 CNP CNP MICAL1 MICAL1 RPA3 RPA3 BRCA1 BRCA1 LOC103255792 LOC103255792 FANCE FANCE HES1 HES1 EME2 EME2 ENSTSYP00000026537 ENSTSYP00000026537 ENSTSYP00000026533 ENSTSYP00000026533 FANCL FANCL NUTF2 NUTF2 FAAP24 FAAP24 CENPX CENPX LOC103250844 LOC103250844 FAAP100 FAAP100 FANCM FANCM PITHD1 PITHD1 LOC103269823 LOC103269823 ERCC1 ERCC1 MICAL3 MICAL3 CENPS CENPS FANCF FANCF RPA4 RPA4 ENSTSYP00000015834 ENSTSYP00000015834 SLX1A SLX1A LOC103257637 LOC103257637
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FANCGFanconi anemia group G protein isoform X1. (621 aa)
RMI2recQ-mediated genome instability protein 2. (147 aa)
FANCAFanconi anemia group A protein. (1446 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3391 aa)
N4BP2L1NEDD4-binding protein 2-like 1 isoform X1. (214 aa)
ERCC4DNA repair endonuclease XPF isoform X1. (916 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (349 aa)
UBE2TUbiquitin-conjugating enzyme E2 T isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (195 aa)
PMS2Mismatch repair endonuclease PMS2 isoform X2. (862 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
FANCD2LOW QUALITY PROTEIN: Fanconi anemia group D2 protein. (1346 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
N4BP2NEDD4-binding protein 2. (1762 aa)
POLKDNA polymerase kappa. (804 aa)
MLH1DNA mismatch repair protein Mlh1 isoform X1. (757 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
FANCBFanconi anemia group B protein. (857 aa)
RAD51CDNA repair protein RAD51 homolog 3. (366 aa)
POLQDNA polymerase theta. (2126 aa)
SLX4LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4. (1796 aa)
POLIDNA polymerase iota isoform X1. (739 aa)
RPA2Replication protein A 32 kDa subunit. (231 aa)
SASS6Spindle assembly abnormal protein 6 homolog. (656 aa)
BRIP1Fanconi anemia group J protein. (1246 aa)
REV3LDNA polymerase zeta catalytic subunit isoform X1. (3097 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1242 aa)
EME1Crossover junction endonuclease EME1. (572 aa)
BLMBloom syndrome protein isoform X1. (1413 aa)
MICAL2F-actin-methionine sulfoxide oxidase MICAL2 isoform X7. (1125 aa)
FANCIFanconi anemia group I protein isoform X1. (1299 aa)
MICALCLMICAL C-terminal-like protein. (675 aa)
FANCCFanconi anemia group C protein. (118 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1027 aa)
PALB2Partner and localizer of BRCA2 isoform X1. (1177 aa)
TELO2Telomere length regulation protein TEL2 homolog. (833 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (784 aa)
ATRIPATR-interacting protein isoform X1. (743 aa)
ENSTSYP00000033658annotation not available (79 aa)
MUS81Crossover junction endonuclease MUS81. (551 aa)
LOC103252213Breast cancer type 1 susceptibility protein-like. (97 aa)
PAPD4poly(A) RNA polymerase GLD2 isoform X1. (484 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (401 aa)
MICAL1F-actin-methionine sulfoxide oxidase MICAL1 isoform X1. (1082 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (180 aa)
LOC103255792Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (341 aa)
FANCEFanconi anemia group E protein. (539 aa)
HES1Transcription factor HES-1. (272 aa)
EME2Probable crossover junction endonuclease EME2. (373 aa)
ENSTSYP00000026537annotation not available (171 aa)
ENSTSYP00000026533annotation not available (256 aa)
FANCLE3 ubiquitin-protein ligase FANCL. (343 aa)
NUTF2Nuclear transport factor 2 isoform X2. (127 aa)
FAAP24Fanconi anemia core complex-associated protein 24 isoform X1. (215 aa)
CENPXCentromere protein X isoform X2. (79 aa)
LOC103250844WD repeat-containing protein 48. (134 aa)
FAAP100Fanconi anemia core complex-associated protein 100. (872 aa)
FANCMFanconi anemia group M protein. (670 aa)
PITHD1PITH domain-containing protein 1. (251 aa)
LOC103269823NEDD4-binding protein 2-like 2. (582 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (298 aa)
MICAL3F-actin-methionine sulfoxide oxidase MICAL3. (1998 aa)
CENPSCentromere protein S. (137 aa)
FANCFFanconi anemia group F protein. (370 aa)
RPA4Replication protein A 30 kDa subunit. (261 aa)
ENSTSYP00000015834annotation not available (104 aa)
SLX1ALOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX1. (62 aa)
LOC103257637DNA polymerase eta. (358 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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