STRINGSTRING
SOS2 SOS2 BTC BTC ABL1 ABL1 CBLB CBLB SOS1 SOS1 PAK3 PAK3 HRAS HRAS CSDE1 CSDE1 PRKCA PRKCA PLCG1 PLCG1 PIK3CA PIK3CA KRAS KRAS PAK5 PAK5 NRG4 NRG4 PAK1 PAK1 EREG EREG MAPK10 MAPK10 REM2 REM2 EGFR EGFR LOC103271002 LOC103271002 NRG3 NRG3 GAB1 GAB1 RAF1 RAF1 ERBB4 ERBB4 ELK1 ELK1 CEP152 CEP152 TMEFF2 TMEFF2 BRAF BRAF EGF EGF AREG AREG AKT3 AKT3 SHC1 SHC1 HBEGF HBEGF PAK2 PAK2 PRKCB PRKCB MTOR MTOR CAMK2A CAMK2A SHC4 SHC4 CAMK2G CAMK2G MAP2K7 MAP2K7 ERBB2 ERBB2 PAK4 PAK4 MAP2K4 MAP2K4 ENSTSYP00000014856 ENSTSYP00000014856 AKT2 AKT2 PLCG2 PLCG2 GSK3B GSK3B CAMK2D CAMK2D ENSTSYP00000016797 ENSTSYP00000016797 MAP2K1 MAP2K1 STAT5B STAT5B RPS6KB1 RPS6KB1 PIK3R1 PIK3R1 LOC110594926 LOC110594926 ENSTSYP00000021792 ENSTSYP00000021792 ENSTSYP00000021856 ENSTSYP00000021856 TGFA TGFA ABL2 ABL2 STAT5A STAT5A SHC3 SHC3 ENSTSYP00000024479 ENSTSYP00000024479 LOC103275563 LOC103275563 NRAS NRAS PTK2 PTK2 PIK3R3 PIK3R3 MAPK8 MAPK8 LOC103251709 LOC103251709 LOC103269691 LOC103269691 CDKN1A CDKN1A PAK6 PAK6 NRG1 NRG1 ARSI ARSI CAMK2B CAMK2B MAPK3 MAPK3 MSANTD3-TMEFF1 MSANTD3-TMEFF1 CDKN1B CDKN1B NCK1 NCK1 ARAF ARAF PIK3CD PIK3CD CBL CBL EPGN EPGN MYC MYC AKT1 AKT1 MAPK9 MAPK9 RPS6KB2 RPS6KB2 RRAD RRAD GEM GEM MAPK1 MAPK1 GRB2 GRB2 SRC SRC PRKCG PRKCG NRG2 NRG2 CRK CRK REM1 REM1 PIK3CB PIK3CB CRKL CRKL ALKBH4 ALKBH4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
BTCProbetacellulin. (178 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (580 aa)
HRASGTPase HRas isoform X6. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (842 aa)
PRKCAProtein kinase C. (614 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KRASGTPase KRas isoform X1. (189 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
EREGProepiregulin. (167 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
LOC103271002Receptor tyrosine-protein kinase erbB-3. (580 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X2. (344 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (700 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ERBB4Receptor protein-tyrosine kinase. (1280 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (430 aa)
CEP152Centrosomal protein of 152 kDa. (1704 aa)
TMEFF2Tomoregulin-2. (340 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
AREGAmphiregulin isoform X1. (270 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
SHC1SHC-transforming protein 1 isoform X1. (474 aa)
HBEGFProheparin-binding EGF-like growth factor. (209 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PRKCBNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (531 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
SHC4SHC-transforming protein 4. (629 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (566 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (414 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PAK4Non-specific serine/threonine protein kinase. (567 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (387 aa)
ENSTSYP00000014856annotation not available (69 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (403 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (533 aa)
ENSTSYP00000016797annotation not available (58 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
LOC110594926ETS domain-containing protein Elk-3-like. (73 aa)
ENSTSYP00000021792annotation not available (85 aa)
ENSTSYP00000021856annotation not available (88 aa)
TGFATransforming growth factor alpha. (164 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
STAT5ASignal transducer and activator of transcription. (669 aa)
SHC3SHC-transforming protein 3. (107 aa)
ENSTSYP00000024479annotation not available (60 aa)
LOC103275563Receptor tyrosine-protein kinase erbB-3. (169 aa)
NRASGTPase NRas. (189 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
LOC103269691myb/SANT-like DNA-binding domain-containing protein 3 isoform X2. (268 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
ARSIArylsulfatase I. (535 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (666 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
MSANTD3-TMEFF1Tomoregulin-1 isoform X1. (454 aa)
CDKN1BLOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1B. (197 aa)
NCK1Cytoplasmic protein. (377 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
CBLE3 ubiquitin-protein ligase CBL. (898 aa)
EPGNEpigen isoform X1. (153 aa)
MYCMyc proto-oncogene protein. (376 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
RRADGTP-binding protein RAD. (275 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
SRCTyrosine-protein kinase. (542 aa)
PRKCGProtein kinase C. (634 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (243 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (331 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
CRKLCrk-like protein. (303 aa)
ALKBH4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4. (292 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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