STRINGSTRING
IL6R IL6R LOC103268849 LOC103268849 TFRC TFRC EP300 EP300 IFNG IFNG CYBB CYBB LOC103269310 LOC103269310 IGF1R IGF1R ALDOB ALDOB ENO1 ENO1 HK2 HK2 TLR4 TLR4 PRKCA PRKCA PLCG1 PLCG1 PIK3CA PIK3CA ALDOA ALDOA NFKB1 NFKB1 PFKM PFKM IFNGR1 IFNGR1 ARNT ARNT PDHA1 PDHA1 EGFR EGFR LOC103271953 LOC103271953 ENO3 ENO3 PGK1 PGK1 LDHA LDHA IFNGR2 IFNGR2 LDHAL6A LDHAL6A EGF EGF LOC103251683 LOC103251683 EIF4E EIF4E ANGPT1 ANGPT1 AKT3 AKT3 SLC2A1 SLC2A1 LTF LTF EDN1 EDN1 ANGPT2 ANGPT2 PRKCB PRKCB STAT3 STAT3 MTOR MTOR LDHB LDHB EIF4E2 EIF4E2 CAMK2A CAMK2A CAMK2G CAMK2G ERBB2 ERBB2 LOC110596830 LOC110596830 LOC103264991 LOC103264991 AKT2 AKT2 HIF1A HIF1A PLCG2 PLCG2 FCGBP FCGBP CAMK2D CAMK2D ENSTSYP00000016630 ENSTSYP00000016630 ENSTSYP00000016731 ENSTSYP00000016731 ENSTSYP00000016868 ENSTSYP00000016868 ENSTSYP00000017269 ENSTSYP00000017269 ENO2 ENO2 ENSTSYP00000017666 ENSTSYP00000017666 ENSTSYP00000017758 ENSTSYP00000017758 ENO4 ENO4 MAP2K1 MAP2K1 ENSTSYP00000018357 ENSTSYP00000018357 ENSTSYP00000018400 ENSTSYP00000018400 EIF4E1B EIF4E1B VEGFA VEGFA RPS6KB1 RPS6KB1 RBX1 RBX1 ENSTSYP00000019824 ENSTSYP00000019824 PDHB PDHB TEK TEK ENSTSYP00000020188 ENSTSYP00000020188 ZAN ZAN PIK3R1 PIK3R1 PFKL PFKL EGLN2 EGLN2 ENSTSYP00000021792 ENSTSYP00000021792 HK1 HK1 HK3 HK3 PDK1 PDK1 RPS6 RPS6 ENSTSYP00000022968 ENSTSYP00000022968 INSR INSR PFKFB3 PFKFB3 ENSTSYP00000023992 ENSTSYP00000023992 ELOB ELOB ALDOC ALDOC RELA RELA ELOC ELOC PIK3R3 PIK3R3 TIMP1 TIMP1 PFKP PFKP NOS3 NOS3 CUL2 CUL2 LOC103251709 LOC103251709 LOC103265127 LOC103265127 HMOX1 HMOX1 LOC103251021 LOC103251021 NPPA NPPA CDKN1A CDKN1A ENSTSYP00000027576 ENSTSYP00000027576 ARSI ARSI CAMK2B CAMK2B MAPK3 MAPK3 ENSTSYP00000028112 ENSTSYP00000028112 TF TF HKDC1 HKDC1 CDKN1B CDKN1B ANGPT4 ANGPT4 SERPINE1 SERPINE1 NOS2 NOS2 MKNK1 MKNK1 IGF1 IGF1 PIK3CD PIK3CD ENSTSYP00000030405 ENSTSYP00000030405 ENSTSYP00000030772 ENSTSYP00000030772 AKT1 AKT1 ENSTSYP00000031193 ENSTSYP00000031193 EPO EPO LTBR LTBR RPS6KB2 RPS6KB2 IL6 IL6 ENSTSYP00000031894 ENSTSYP00000031894 MAPK1 MAPK1 LOC103269899 LOC103269899 LOC103274775 LOC103274775 CREBBP CREBBP LOC103277171 LOC103277171 PRKCG PRKCG PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
LOC103268849Tubulin-specific chaperone A; Belongs to the TBCA family. (121 aa)
TFRCTransferrin receptor protein 1. (760 aa)
EP300Histone acetyltransferase p300. (2174 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
CYBBCytochrome b-245 heavy chain isoform X1. (570 aa)
LOC103269310Egl nine homolog 3. (145 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
ENO1Alpha-enolase isoform X1. (434 aa)
HK2Hexokinase-2. (917 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (840 aa)
PRKCAProtein kinase C. (614 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (418 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
IFNGR1Interferon gamma receptor 1. (478 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (761 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (422 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
LOC103271953Vascular endothelial growth factor receptor 1-like. (713 aa)
ENO3Beta-enolase isoform X1. (434 aa)
PGK1Phosphoglycerate kinase. (417 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
IFNGR2Interferon gamma receptor 2. (317 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (281 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
LOC103251683Insulin-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (99 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (460 aa)
LTFLactotransferrin isoform X1; Belongs to the transferrin family. (710 aa)
EDN1Endothelin-1. (202 aa)
ANGPT2Angiopoietin-2 isoform X1. (495 aa)
PRKCBNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (531 aa)
STAT3Signal transducer and activator of transcription 3. (444 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X2; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (566 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LOC110596830Keratin-associated protein 10-10-like. (139 aa)
LOC103264991Vascular endothelial growth factor receptor 1 isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (431 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (842 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
FCGBPIgGFc-binding protein. (2437 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X4. (533 aa)
ENSTSYP00000016630annotation not available (227 aa)
ENSTSYP00000016731annotation not available (218 aa)
ENSTSYP00000016868annotation not available (192 aa)
ENSTSYP00000017269annotation not available (84 aa)
ENO2Gamma-enolase. (402 aa)
ENSTSYP00000017666annotation not available (385 aa)
ENSTSYP00000017758annotation not available (110 aa)
ENO4Enolase 4. (628 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
ENSTSYP00000018357annotation not available (414 aa)
ENSTSYP00000018400annotation not available (338 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (228 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
ENSTSYP00000019824annotation not available (90 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
ENSTSYP00000020188annotation not available (70 aa)
ZANLOW QUALITY PROTEIN: zonadhesin. (2533 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (774 aa)
EGLN2Egl nine homolog 2. (405 aa)
ENSTSYP00000021792annotation not available (85 aa)
HK1Hexokinase-1 isoform X1. (917 aa)
HK3LOW QUALITY PROTEIN: hexokinase-3. (924 aa)
PDK1Protein-serine/threonine kinase. (403 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ENSTSYP00000022968annotation not available (133 aa)
INSRTyrosine-protein kinase receptor. (1356 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3. (529 aa)
ENSTSYP00000023992annotation not available (192 aa)
ELOBelongin-B. (97 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
RELATranscription factor p65. (519 aa)
ELOCelongin-C isoform X2; Belongs to the SKP1 family. (112 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
TIMP1Metalloproteinase inhibitor 1 isoform X2. (207 aa)
PFKPATP-dependent 6-phosphofructokinase, platelet type. (742 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
CUL2Cullin-2; Belongs to the cullin family. (745 aa)
LOC103251709Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (348 aa)
LOC103265127L-lactate dehydrogenase C chain-like. (139 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
LOC103251021Egl nine homolog 1. (128 aa)
NPPANatriuretic peptides A. (153 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
ENSTSYP00000027576annotation not available (278 aa)
ARSIArylsulfatase I. (535 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (666 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
ENSTSYP00000028112annotation not available (112 aa)
TFLOW QUALITY PROTEIN: serotransferrin-like. (697 aa)
HKDC1Putative hexokinase HKDC1. (855 aa)
CDKN1BLOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1B. (197 aa)
ANGPT4Angiopoietin-4. (488 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (445 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
ENSTSYP00000030405annotation not available (247 aa)
ENSTSYP00000030772annotation not available (208 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
ENSTSYP00000031193annotation not available (420 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (435 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
IL6Interleukin-6. (209 aa)
ENSTSYP00000031894annotation not available (263 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
LOC103269899LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (323 aa)
LOC103274775L-lactate dehydrogenase A chain-like; Belongs to the LDH/MDH superfamily. (349 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
LOC103277171LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like. (248 aa)
PRKCGProtein kinase C. (634 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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