STRINGSTRING
CDC23 CDC23 YWHAE YWHAE ENSTSYP00000008181 ENSTSYP00000008181 CDC25C CDC25C CDK7 CDK7 ENSTSYP00000035030 ENSTSYP00000035030 ENSTSYP00000034921 ENSTSYP00000034921 RBL2 RBL2 MCM4 MCM4 MAD2L2 MAD2L2 CDK2 CDK2 ENSTSYP00000033058 ENSTSYP00000033058 CREBBP CREBBP ENSTSYP00000033016 ENSTSYP00000033016 BUB1 BUB1 CDKN2D CDKN2D TGFB2 TGFB2 PRKDC PRKDC ENSTSYP00000031351 ENSTSYP00000031351 CNTD2 CNTD2 ENSTSYP00000031072 ENSTSYP00000031072 TGFB1 TGFB1 LOC103252110 LOC103252110 MYC MYC PKMYT1 PKMYT1 ENSTSYP00000030504 ENSTSYP00000030504 ANAPC2 ANAPC2 ANAPC13 ANAPC13 TGFB3 TGFB3 SMAD3 SMAD3 YWHAH YWHAH ENSTSYP00000029126 ENSTSYP00000029126 FZR1 FZR1 CCND2 CCND2 TMEM82 TMEM82 CDKN1B CDKN1B CDC14B CDC14B ZBTB47 ZBTB47 CDKN1A CDKN1A CDKN2C CDKN2C PTTG1 PTTG1 ANAPC10 ANAPC10 LOC103252434 LOC103252434 HDAC1 HDAC1 CHEK2 CHEK2 RAD21L1 RAD21L1 CDK20 CDK20 ENSTSYP00000024958 ENSTSYP00000024958 ENSTSYP00000024947 ENSTSYP00000024947 YWHAQ YWHAQ SFN SFN ENSTSYP00000024257 ENSTSYP00000024257 AP5S1 AP5S1 STAG1 STAG1 E2F1 E2F1 ANAPC11 ANAPC11 CDC25B CDC25B TP53 TP53 ENSTSYP00000023689 ENSTSYP00000023689 ENSTSYP00000023430 ENSTSYP00000023430 LOC103266579 LOC103266579 CCNE2 CCNE2 LOC103250373 LOC103250373 CHEK1 CHEK1 CCND1 CCND1 YWHAB YWHAB MCM3 MCM3 E2F3 E2F3 BUB3 BUB3 ENSTSYP00000021013 ENSTSYP00000021013 SKP2 SKP2 CDC26 CDC26 RBX1 RBX1 CDK1 CDK1 ENSTSYP00000019167 ENSTSYP00000019167 PCNA PCNA ZBTB10 ZBTB10 CDKN2A CDKN2A ENSTSYP00000017776 ENSTSYP00000017776 CDC16 CDC16 ANAPC1 ANAPC1 ENSTSYP00000017308 ENSTSYP00000017308 CDC45 CDC45 ENSTSYP00000017183 ENSTSYP00000017183 ORC6 ORC6 ENSTSYP00000016277 ENSTSYP00000016277 CUL1 CUL1 CDK3 CDK3 GSK3B GSK3B CDC25A CDC25A FAM126B FAM126B CCND3 CCND3 ENSTSYP00000014599 ENSTSYP00000014599 ENSTSYP00000014079 ENSTSYP00000014079 MCM5 MCM5 SNAPIN SNAPIN STAG2 STAG2 E2F5 E2F5 FBXW12 FBXW12 ORC1 ORC1 CCNB2 CCNB2 CDK6 CDK6 CDC20 CDC20 ANAPC5 ANAPC5 WEE2 WEE2 MAD2L1 MAD2L1 CDC20B CDC20B BUB1B BUB1B CDK4 CDK4 CCNA2 CCNA2 ATR ATR MCM6 MCM6 CDKN2B CDKN2B ANAPC7 ANAPC7 CCNE1 CCNE1 SMC3 SMC3 SMAD2 SMAD2 SMC1A SMC1A CDC7 CDC7 CCNA1 CCNA1 YWHAZ YWHAZ MCM2 MCM2 ORC3 ORC3 ORC4 ORC4 CDC6 CDC6 E2F4 E2F4 CCNB3 CCNB3 DBF4 DBF4 CDC27 CDC27 ABL1 ABL1 MCM7 MCM7 MYNN MYNN CDC14A CDC14A RB1 RB1 PLK1 PLK1 ANAPC4 ANAPC4 EP300 EP300 ENSTSYP00000000146 ENSTSYP00000000146 ESPL1 ESPL1 WEE1 WEE1 CCNH CCNH ZNF652 ZNF652 SMC1B SMC1B SKP1 SKP1 ZBTB46 ZBTB46 ORC2 ORC2 RBL1 RBL1 YWHAG YWHAG E2F2 E2F2 SMAD4 SMAD4 RAD21 RAD21 ATM ATM TTK TTK HDAC2 HDAC2 TFDP2 TFDP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC23Cell division cycle protein 23 homolog. (597 aa)
YWHAE14-3-3 protein epsilon isoform X2; Belongs to the 14-3-3 family. (255 aa)
ENSTSYP00000008181annotation not available (412 aa)
CDC25CM-phase inducer phosphatase 3. (464 aa)
CDK7Cyclin-dependent kinase 7 isoform X1. (332 aa)
ENSTSYP00000035030annotation not available (263 aa)
ENSTSYP00000034921annotation not available (296 aa)
RBL2Retinoblastoma-like protein 2 isoform X1. (1141 aa)
MCM4DNA helicase; Belongs to the MCM family. (860 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (223 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
ENSTSYP00000033058annotation not available (142 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
ENSTSYP00000033016annotation not available (307 aa)
BUB1Mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1. (1085 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (3073 aa)
ENSTSYP00000031351annotation not available (442 aa)
CNTD2LOW QUALITY PROTEIN: cyclin N-terminal domain-containing protein 2; Belongs to the cyclin family. (207 aa)
ENSTSYP00000031072annotation not available (165 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
LOC103252110G2/mitotic-specific cyclin-B1 isoform X1; Belongs to the cyclin family. (433 aa)
MYCMyc proto-oncogene protein. (376 aa)
PKMYT1Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Belongs to the protein kinase superfamily. (545 aa)
ENSTSYP00000030504annotation not available (156 aa)
ANAPC2Anaphase-promoting complex subunit 2. (577 aa)
ANAPC13Anaphase-promoting complex subunit 13. (74 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
ENSTSYP00000029126annotation not available (466 aa)
FZR1Fizzy-related protein homolog. (449 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (231 aa)
TMEM82Transmembrane protein 82. (360 aa)
CDKN1BLOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1B. (197 aa)
CDC14BDual specificity protein phosphatase CDC14B. (498 aa)
ZBTB47Zinc finger and BTB domain-containing protein 47. (713 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
PTTG1Securin isoform X1. (201 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
LOC103252434Mitotic spindle assembly checkpoint protein MAD1-like. (243 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (582 aa)
RAD21L1Double-strand-break repair protein rad21-like protein 1. (553 aa)
CDK20Cyclin-dependent kinase 20 isoform X1. (288 aa)
ENSTSYP00000024958annotation not available (55 aa)
ENSTSYP00000024947annotation not available (143 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
ENSTSYP00000024257annotation not available (242 aa)
AP5S1AP-5 complex subunit sigma-1. (199 aa)
STAG1Cohesin subunit SA-1 isoform X1. (1258 aa)
E2F1Transcription factor E2F1. (350 aa)
ANAPC11Anaphase-promoting complex subunit 11 isoform X1. (84 aa)
CDC25BM-phase inducer phosphatase 2 isoform X1. (575 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
ENSTSYP00000023689annotation not available (139 aa)
ENSTSYP00000023430annotation not available (374 aa)
LOC103266579Growth arrest and DNA damage-inducible protein GADD45 alpha-like. (84 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa)
LOC103250373E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (426 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
YWHAB14-3-3 protein beta/alpha isoform X1; Belongs to the 14-3-3 family. (246 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
E2F3Transcription factor E2F3. (334 aa)
BUB3Mitotic checkpoint protein BUB3 isoform X1. (328 aa)
ENSTSYP00000021013annotation not available (135 aa)
SKP2S-phase kinase-associated protein 2. (436 aa)
CDC26Anaphase-promoting complex subunit CDC26 isoform X1. (85 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
CDK1Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (297 aa)
ENSTSYP00000019167annotation not available (267 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ZBTB10Zinc finger and BTB domain-containing protein 10. (697 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A. (171 aa)
ENSTSYP00000017776annotation not available (292 aa)
CDC16Cell division cycle protein 16 homolog. (615 aa)
ANAPC1Anaphase-promoting complex subunit 1. (149 aa)
ENSTSYP00000017308annotation not available (305 aa)
CDC45Cell division control protein 45 homolog isoform X1. (600 aa)
ENSTSYP00000017183annotation not available (581 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
ENSTSYP00000016277annotation not available (582 aa)
CUL1Cullin-1 isoform X1; Belongs to the cullin family. (776 aa)
CDK3Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (305 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (403 aa)
CDC25AM-phase inducer phosphatase 1 isoform X1. (523 aa)
FAM126BProtein FAM126B isoform X2. (530 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
ENSTSYP00000014599annotation not available (238 aa)
ENSTSYP00000014079annotation not available (191 aa)
MCM5DNA replication licensing factor MCM5; Belongs to the MCM family. (598 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
STAG2Cohesin subunit SA-2 isoform X1. (1268 aa)
E2F5Transcription factor E2F5 isoform X1. (300 aa)
FBXW12F-box/WD repeat-containing protein 12. (465 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa)
CDK6Cyclin-dependent kinase 6. (264 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
ANAPC5Anaphase-promoting complex subunit 5. (613 aa)
WEE2Wee1-like protein kinase. (567 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A isoform X1. (205 aa)
CDC20BCell division cycle protein 20 homolog B isoform X1. (516 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1049 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (430 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
ANAPC7Anaphase-promoting complex subunit 7. (588 aa)
CCNE1G1/S-specific cyclin-E1. (410 aa)
SMC3Structural maintenance of chromosomes protein. (1208 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMC1AStructural maintenance of chromosomes protein. (1235 aa)
CDC7Cell division cycle 7-related protein kinase isoform X1. (574 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (455 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (254 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
ORC3Origin recognition complex subunit 3 isoform X2. (711 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (435 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
E2F4Transcription factor E2F4. (407 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1107 aa)
DBF4Protein DBF4 homolog A. (665 aa)
CDC27Cell division cycle protein 27 homolog isoform X1. (828 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (714 aa)
MYNNMyoneurin isoform X1. (609 aa)
CDC14ADual specificity protein phosphatase CDC14A isoform X1. (575 aa)
RB1Retinoblastoma-associated protein. (929 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
EP300Histone acetyltransferase p300. (2174 aa)
ENSTSYP00000000146annotation not available (178 aa)
ESPL1Separin. (1576 aa)
WEE1Wee1-like protein kinase. (432 aa)
CCNHcyclin-H; Belongs to the cyclin family. (232 aa)
ZNF652Zinc finger protein 652. (608 aa)
SMC1BStructural maintenance of chromosomes protein. (1235 aa)
SKP1S-phase kinase-associated protein 1 isoform X2; Belongs to the SKP1 family. (163 aa)
ZBTB46Zinc finger and BTB domain-containing protein 46. (589 aa)
ORC2Origin recognition complex subunit 2 isoform X1. (574 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (233 aa)
E2F2Transcription factor E2F2. (423 aa)
SMAD4Mothers against decapentaplegic homolog. (551 aa)
RAD21Double-strand-break repair protein rad21 homolog. (632 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
TTKDual specificity protein kinase TTK isoform X1. (851 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
TFDP2Transcription factor. (448 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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