STRINGSTRING
FCGR2B FCGR2B TYROBP TYROBP MAPK14 MAPK14 LILRB3 LILRB3 IFNG IFNG TGFBR2 TGFBR2 NCF2 NCF2 IKBKB IKBKB PPP3CC PPP3CC NFKBIA NFKBIA PIK3CA PIK3CA CHUK CHUK RELB RELB NFKB1 NFKB1 NFATC2 NFATC2 MAPK10 MAPK10 IFNGR1 IFNGR1 LOC103269362 LOC103269362 CTSK CTSK RELCH RELCH NOX1 NOX1 CREB1 CREB1 JAK1 JAK1 NCF4 NCF4 CALCR CALCR IRF9 IRF9 TAB2 TAB2 IL1B IL1B LOC103258295 LOC103258295 CAMK4 CAMK4 ENSTSYP00000007944 ENSTSYP00000007944 IFNGR2 IFNGR2 LOC103259375 LOC103259375 MAP3K14 MAP3K14 BTK BTK IL1R1 IL1R1 IGSF1 IGSF1 AKT3 AKT3 ENSTSYP00000010448 ENSTSYP00000010448 IL1A IL1A PPP3R1 PPP3R1 SQSTM1 SQSTM1 FYN FYN MAP2K7 MAP2K7 IFNAR1 IFNAR1 TNFRSF11A TNFRSF11A AKT2 AKT2 TREM2 TREM2 PPARG PPARG PLCG2 PLCG2 LOC103269498 LOC103269498 SPI1 SPI1 TRAF6 TRAF6 PTK6 PTK6 SOCS3 SOCS3 LOC103250564 LOC103250564 OSCAR OSCAR ACP5 ACP5 MAPK12 MAPK12 SYK SYK CYLD CYLD MAP2K1 MAP2K1 JUNB JUNB TEC TEC NCF1 NCF1 GAB2 GAB2 FOSL2 FOSL2 PIK3R1 PIK3R1 LOC103262282 LOC103262282 LCK LCK NFATC1 NFATC1 PPP3CA PPP3CA MAP2K6 MAP2K6 TNFRSF11B TNFRSF11B RELA RELA LOC103249528 LOC103249528 TNFSF11 TNFSF11 PIK3R3 PIK3R3 LOC103254497 LOC103254497 MAPK8 MAPK8 IKBKG IKBKG MAPK11 MAPK11 BLNK BLNK MAPK13 MAPK13 TNF TNF CSF1 CSF1 TNFRSF1A TNFRSF1A NOXA1 NOXA1 MAPK3 MAPK3 CYBA CYBA FOS FOS PIK3CD PIK3CD LOC103262288 LOC103262288 MAP3K7 MAP3K7 TGFB1 TGFB1 AKT1 AKT1 MAPK9 MAPK9 SPIB SPIB TGFB2 TGFB2 FOSL1 FOSL1 TAB1 TAB1 LCP2 LCP2 MAPK1 MAPK1 PPP3CB PPP3CB MITF MITF GRB2 GRB2 FOSB FOSB SRMS SRMS PIK3CB PIK3CB TGFBR1 TGFBR1 TYK2 TYK2 CSF1R CSF1R FHL2 FHL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b isoform X1. (309 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (110 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LILRB3Leukocyte immunoglobulin-like receptor subfamily B member 3. (615 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (558 aa)
NCF2Neutrophil cytosol factor 2. (526 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PPP3CCSerine/threonine-protein phosphatase. (514 aa)
NFKBIANF-kappa-B inhibitor alpha. (282 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
RELBTranscription factor RelB. (510 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (921 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
IFNGR1Interferon gamma receptor 1. (478 aa)
LOC103269362Interferon alpha/beta receptor 2. (278 aa)
CTSKCathepsin K isoform X1; Belongs to the peptidase C1 family. (329 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (721 aa)
NOX1NADPH oxidase 1 isoform X1. (564 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
JAK1Tyrosine-protein kinase. (1140 aa)
NCF4Neutrophil cytosol factor 4. (339 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (492 aa)
IRF9Interferon regulatory factor 9. (398 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
LOC103258295LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like. (451 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (295 aa)
ENSTSYP00000007944annotation not available (152 aa)
IFNGR2Interferon gamma receptor 2. (317 aa)
LOC103259375High affinity immunoglobulin gamma Fc receptor I-like isoform X1. (371 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (937 aa)
BTKTyrosine-protein kinase. (659 aa)
IL1R1Interleukin-1 receptor type 1. (573 aa)
IGSF1Immunoglobulin superfamily member 1 isoform X1. (752 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
ENSTSYP00000010448annotation not available (247 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
PPP3R1Calcineurin subunit B type 1. (169 aa)
SQSTM1Sequestosome-1 isoform X2. (370 aa)
FYNTyrosine-protein kinase. (537 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (414 aa)
IFNAR1Interferon alpha/beta receptor 1. (561 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (238 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
LOC103269498Immunoglobulin superfamily member 1-like. (243 aa)
SPI1LOW QUALITY PROTEIN: transcription factor PU.1. (259 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (512 aa)
PTK6Tyrosine-protein kinase. (450 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
LOC103250564Integrin beta; Belongs to the integrin beta chain family. (418 aa)
OSCAROsteoclast-associated immunoglobulin-like receptor. (262 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
MAPK12Mitogen-activated protein kinase. (277 aa)
SYKTyrosine-protein kinase. (634 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (953 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
JUNBTranscription factor jun-B isoform X1. (347 aa)
TECTyrosine-protein kinase. (631 aa)
NCF1LOW QUALITY PROTEIN: neutrophil cytosol factor 1. (232 aa)
GAB2GRB2-associated-binding protein 2. (651 aa)
FOSL2Fos-related antigen 2. (292 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
LOC103262282Signal-regulatory protein beta-1-like. (399 aa)
LCKTyrosine-protein kinase. (524 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (905 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAP2K6LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (352 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
RELATranscription factor p65. (519 aa)
LOC103249528Interferon alpha/beta receptor 2-like. (236 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (250 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
LOC103254497lisH domain and HEAT repeat-containing protein KIAA1468-like. (391 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
IKBKGNF-kappa-B essential modulator. (460 aa)
MAPK11Mitogen-activated protein kinase. (255 aa)
BLNKB-cell linker protein. (439 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
CSF1Macrophage colony-stimulating factor 1. (244 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (183 aa)
NOXA1NADPH oxidase activator 1. (384 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
CYBACytochrome b-245 light chain. (176 aa)
FOSProto-oncogene c-Fos. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
LOC103262288Tyrosine-protein phosphatase non-receptor type substrate 1-like. (181 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SPIBTranscription factor Spi-B. (178 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FOSL1Fos-related antigen 1 isoform X1. (272 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2. (504 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (419 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
FOSBProtein fosB. (191 aa)
SRMSTyrosine-protein kinase. (424 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (487 aa)
TYK2Tyrosine-protein kinase. (869 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (965 aa)
FHL2Four and a half LIM domains protein 2 isoform X1. (279 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
Server load: low (16%) [HD]