STRINGSTRING
SOS2 SOS2 EP300 EP300 LIFR LIFR LOC103256403 LOC103256403 CNTFR CNTFR IL13 IL13 IFNG IFNG IL21 IL21 PTPN11 PTPN11 AOX1 AOX1 STAM STAM SOS1 SOS1 IL22RA2 IL22RA2 HRAS HRAS LOC103259924 LOC103259924 CISH CISH SOCS5 SOCS5 PIK3CA PIK3CA IL5RA IL5RA PDGFRA PDGFRA IL10 IL10 IFNGR1 IFNGR1 LOC103269362 LOC103269362 EGFR EGFR JAK1 JAK1 IL23R IL23R CSF3R CSF3R RAF1 RAF1 IRF9 IRF9 THPO THPO LOC103258295 LOC103258295 IL13RA2 IL13RA2 CSF2 CSF2 IFNGR2 IFNGR2 IL19 IL19 OSMR OSMR EGF EGF IL20RB IL20RB IL4 IL4 JAK2 JAK2 IL5 IL5 IL13RA1 IL13RA1 AKT3 AKT3 TSLP TSLP IL15 IL15 IL10RA IL10RA IL7R IL7R GHR GHR IL22RA1 IL22RA1 IFNLR1 IFNLR1 STAT3 STAT3 MTOR MTOR IL2RG IL2RG IL20RA IL20RA IL2RA IL2RA IL9 IL9 STAM2 STAM2 IL22 IL22 IL12B IL12B IL27RA IL27RA MPL MPL BCL2L1 BCL2L1 LEPR LEPR IFNAR1 IFNAR1 CCND3 CCND3 ENSTSYP00000014702 ENSTSYP00000014702 AKT2 AKT2 PTPN6 PTPN6 FCGBP FCGBP IL21R IL21R CSF2RB CSF2RB SOCS3 SOCS3 IL23A IL23A IL6ST IL6ST PIAS2 PIAS2 PIM1 PIM1 IL7 IL7 EPOR EPOR STAT5B STAT5B IL12RB2 IL12RB2 IL11 IL11 OSM OSM IL12RB1 IL12RB1 ZAN ZAN PIK3R1 PIK3R1 IL2RB IL2RB ENSTSYP00000022061 ENSTSYP00000022061 PIAS3 PIAS3 PIAS4 PIAS4 CCND1 CCND1 SOCS6 SOCS6 LOC103255989 LOC103255989 CTF1 CTF1 STAT5A STAT5A SOCS4 SOCS4 LOC103249528 LOC103249528 LIF LIF PIK3R3 PIK3R3 CSF3 CSF3 IL24 IL24 ENSTSYP00000026816 ENSTSYP00000026816 LOC103271036 LOC103271036 PRLR PRLR CDKN1A CDKN1A CCND2 CCND2 IL2 IL2 PDGFRB PDGFRB GH1 GH1 GFAP GFAP IL9R IL9R IL15RA IL15RA PDGFB PDGFB PIK3CD PIK3CD IL20 IL20 LOC103271035 LOC103271035 MYC MYC AKT1 AKT1 FHL1 FHL1 ENSTSYP00000031096 ENSTSYP00000031096 IL4R IL4R EPO EPO PIAS1 PIAS1 SOCS7 SOCS7 IL6 IL6 ENSTSYP00000031894 ENSTSYP00000031894 PTPN2 PTPN2 CREBBP CREBBP GRB2 GRB2 LOC103277171 LOC103277171 PDGFA PDGFA CNTF CNTF PIK3CB PIK3CB IL6R IL6R STAT6 STAT6 TYK2 TYK2 IL12A IL12A PRL PRL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
EP300Histone acetyltransferase p300. (2174 aa)
LIFRLeukemia inhibitory factor receptor. (1097 aa)
LOC103256403Signal transducer and activator of transcription 4. (281 aa)
CNTFRCiliary neurotrophic factor receptor subunit alpha. (372 aa)
IL13Interleukin-13. (139 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (532 aa)
AOX1Aldehyde oxidase. (1323 aa)
STAMSignal transducing adapter molecule 1 isoform X1. (538 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
IL22RA2Interleukin-22 receptor subunit alpha-2. (231 aa)
HRASGTPase HRas isoform X6. (189 aa)
LOC103259924Interferon lambda-3-like. (198 aa)
CISHCytokine-inducible SH2-containing protein isoform X1. (274 aa)
SOCS5Suppressor of cytokine signaling 5 isoform X1. (515 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL5RAInterleukin-5 receptor subunit alpha. (420 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
IL10Interleukin-10. (178 aa)
IFNGR1Interferon gamma receptor 1. (478 aa)
LOC103269362Interferon alpha/beta receptor 2. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1180 aa)
JAK1Tyrosine-protein kinase. (1140 aa)
IL23RInterleukin-23 receptor. (628 aa)
CSF3RLOW QUALITY PROTEIN: granulocyte colony-stimulating factor receptor. (820 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
IRF9Interferon regulatory factor 9. (398 aa)
THPOThrombopoietin isoform X1. (359 aa)
LOC103258295LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like. (451 aa)
IL13RA2Interleukin-13 receptor subunit alpha-2. (285 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
IFNGR2Interferon gamma receptor 2. (317 aa)
IL19Interleukin-19. (177 aa)
OSMRoncostatin-M-specific receptor subunit beta. (323 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
IL20RBInterleukin-20 receptor subunit beta. (311 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (142 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL13RA1Interleukin-13 receptor subunit alpha-1. (427 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (419 aa)
TSLPThymic stromal lymphopoietin. (291 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL10RAInterleukin-10 receptor subunit alpha. (581 aa)
IL7RInterleukin-7 receptor subunit alpha. (459 aa)
GHRGrowth hormone receptor. (614 aa)
IL22RA1Interleukin-22 receptor subunit alpha-1. (566 aa)
IFNLR1Interferon lambda receptor 1. (558 aa)
STAT3Signal transducer and activator of transcription 3. (444 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IL2RGCytokine receptor common subunit gamma isoform X1. (369 aa)
IL20RAInterleukin-20 receptor subunit alpha. (535 aa)
IL2RAInterleukin-2 receptor subunit alpha. (268 aa)
IL9Interleukin-9. (144 aa)
STAM2Signal transducing adapter molecule 2. (525 aa)
IL22Interleukin-22. (180 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
IL27RALOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha. (441 aa)
MPLLOW QUALITY PROTEIN: thrombopoietin receptor. (632 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LEPRLeptin receptor. (961 aa)
IFNAR1Interferon alpha/beta receptor 1. (561 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
ENSTSYP00000014702annotation not available (476 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (402 aa)
FCGBPIgGFc-binding protein. (2437 aa)
IL21RInterleukin-21 receptor. (530 aa)
CSF2RBCytokine receptor common subunit beta. (899 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
IL6STInterleukin-6 receptor subunit beta. (917 aa)
PIAS2E3 SUMO-protein ligase PIAS2 isoform X2. (613 aa)
PIM1Serine/threonine-protein kinase pim-1. (169 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
EPORErythropoietin receptor. (277 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
IL12RB2Interleukin-12 receptor subunit beta-2. (860 aa)
IL11Interleukin-11. (120 aa)
OSMoncostatin-M. (251 aa)
IL12RB1Interleukin-12 receptor subunit beta-1. (644 aa)
ZANLOW QUALITY PROTEIN: zonadhesin. (2533 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (612 aa)
IL2RBInterleukin-2 receptor subunit beta. (529 aa)
ENSTSYP00000022061annotation not available (180 aa)
PIAS3E3 SUMO-protein ligase PIAS3. (624 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (444 aa)
CCND1G1/S-specific cyclin-D1. (156 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
LOC103255989Signal transducer and activator of transcription 4. (261 aa)
CTF1Cardiotrophin-1. (204 aa)
STAT5ASignal transducer and activator of transcription. (669 aa)
SOCS4Suppressor of cytokine signaling 4. (413 aa)
LOC103249528Interferon alpha/beta receptor 2-like. (236 aa)
LIFLeukemia inhibitory factor. (202 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (461 aa)
CSF3Granulocyte colony-stimulating factor isoform X2. (204 aa)
IL24Interleukin-24. (199 aa)
ENSTSYP00000026816annotation not available (481 aa)
LOC103271036Aldehyde oxidase 2. (1353 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (305 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (231 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
GH1Somatotropin. (214 aa)
GFAPGlial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. (474 aa)
IL9RLOW QUALITY PROTEIN: interleukin-9 receptor-like. (478 aa)
IL15RAInterleukin-15 receptor subunit alpha. (205 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1063 aa)
IL20Interleukin-20 isoform X1. (175 aa)
LOC103271035LOW QUALITY PROTEIN: aldehyde oxidase 4-like. (1311 aa)
MYCMyc proto-oncogene protein. (376 aa)
AKT1Non-specific serine/threonine protein kinase. (393 aa)
FHL1Four and a half LIM domains protein 1 isoform X3. (323 aa)
ENSTSYP00000031096annotation not available (176 aa)
IL4RInterleukin-4 receptor subunit alpha. (812 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
PIAS1E3 SUMO-protein ligase PIAS1. (653 aa)
SOCS7Suppressor of cytokine signaling 7. (576 aa)
IL6Interleukin-6. (209 aa)
ENSTSYP00000031894annotation not available (263 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
LOC103277171LOW QUALITY PROTEIN: signal transducer and activator of transcription 3-like. (248 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (202 aa)
CNTFCiliary neurotrophic factor. (200 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TYK2Tyrosine-protein kinase. (869 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
PRLProlactin. (228 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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